Uric acid, xanthine oxidase and heart failure: Unresolved issues

European Journal of Heart Failure

Volumn 10, Issue 12, 2008, Pages 1271-1272

  Verdejo, Hugo ^a   Alcaino, Hernan ^b,c   Greig, Douglas ^a   Garcia, Lorena ^b,c   Pizarro, Marcela ^c   Chiong, Mario ^b,c   Castro, Pablo ^a   Lavandero, Sergio ^b,c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b Centro FONDAP Estudios Moleculares de la Celula   (Chile)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

Chronic heart failure; Endothelial function; Oxidative stress; Uric acid; Xanthine oxidase

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; OXIPURINOL; URIC ACID; XANTHINE OXIDASE;

ENZYME ACTIVITY; ENZYME INHIBITION; HEART FAILURE; HUMAN; LETTER; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; URIC ACID BLOOD LEVEL; VASCULAR ENDOTHELIUM;

ENDOTHELIUM, VASCULAR; HEART FAILURE; HUMANS; RISK ASSESSMENT; SUPEROXIDE DISMUTASE; URIC ACID; VASODILATION; XANTHINE OXIDASE;

EID: 56349167070     PISSN: 13889842     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejheart.2008.10.006     Document Type: Letter

References (14)

1. Alcaino H., Greig D., Chiong M., et al. Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure. Eur J Heart Fail 10 (2008) 646-651
2. Doehner W., von Haehling S., and Anker S.D. Uric acid as a prognostic marker in acute heart failure - new expectations from an old molecule. Eur J Heart Fail 9 (2007) 437-439
3. Brand F.N., McGee D.L., Kannel W.B., Stokes J., and Castelli W.P. Hyperuricemia as a risk factor of coronary heart disease: the Framingham study. Am J Epidemiol 121 (1985) 11-18
4. Iribarren C., Folsom A.R., Eckfeldt J.H., McGovern P.G., and Nieto F.J. Correlates of uric acid and its association with asymptomatic carotid atherosclerosis: the ARIC study. Atherosclerosis risk in communities. Ann Epidemiol 6 (1996) 331-340
5. Ferdinandy P., Danial H., Ambrus I., Rothery R.A., and Schulz R. Peroxy-nitrite is a major contributor to cytokine-induced myocardial contractile failure. Circ Res 87 (2000) 241-247
6. Amado L., Saliaris A., Raju S., et al. Xanthine oxidase inhibition ameliorates cardiovascular dysfunction in dogs with pacing-induced heart failure. J Mol Cell Cardiol 39 (2005) 531-536
7. de Jong J.W., Schoemaker R.G., de Jonge R., et al. Enhanced expression and activity of xanthine oxidoreductase in the failing heart. J Mol Cell Cardiol 32 (2000) 2083-2089
8. Landmesser U., Spiekermann S., Dikalov S., et al. Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation 106 (2002) 3073-3078
9. Nieto F.J., Iribarren C., Gross M.D., Comstock G.W., and Cutler R.G. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?. Atherosclerosis 148 (2000) 131-139
10. Tan S., Radi R., Gaudier F., et al. Physiologic levels of uric acid inhibit xanthine oxidase in human plasma. Pediatr Res 34 (1993) 303-307
11. Squadrito G.L., Cueto R., Splenser A.E., et al. Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid. Arch Biochem Biophys 376 (2000) 333-337
12. Ames B.N., Cathcart R., Schwiers E., and Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA 78 (1981) 6858-6862
13. Boueiz A., Damarla M., and Hassoun P. Xanthine oxidoreductase in respiratory and cardiovascular disorders. Am J Physiol 294 (2008) L830-L840
14. Hare J., Mangal B., Brown J., et al. Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study. J Am Coll Cardiol 51 (2008) 2301-2309