Break Free of the Matrix: Sensitive and Rapid Analysis of Small Molecules Using Nanostructured Surfaces and LDI-TOF Mass Spectrometry

Journal of Laboratory Automation

Volumn 13, Issue 6, 2008, Pages 314-321

  Daniels, R Hugh ^a   Dikler, Sergei ^b   Li, Esther ^a   Stacey, Catherine ^b  

^a Nanosys Inc   (United States)

^b BRUKER DALTONIK GMBH   (Germany)

Author keywords

drug discovery applications; LDI mass spectrometry; matrix free; nanotechnology

Indexed keywords

COATED MATERIALS; DESORPTION; MASS SPECTROMETERS; MASS SPECTROMETRY; NANOSTRUCTURED MATERIALS; NANOTECHNOLOGY; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS; TARGETS;

ACTIVE SURFACES; ANALYTES; BIOLOGICAL SOLUTIONS; BRUKER DALTONICS; DRUG DISCOVERY APPLICATIONS; EASE OF USES; INORGANIC MATERIALS; LASER DESORPTION/IONIZATION; LDI MASS SPECTROMETRY; LOW MASSES; MATRIX FREE; NANOSCALE; NANOSTRUCTURED SURFACES; NANOSTRUCTURED TARGETS; ORGANIC LAYERS; ORGANIC MOLECULES; PHARMACEUTICAL COMPOUNDS; RAPID ANALYSES; SAMPLE DEPOSITIONS; SAMPLE PREPARATIONS; SMALL MOLECULES; TARGET PLATES; TIME OF FLIGHTS; TOF ANALYSES; TOF MASS SPECTROMETERS; TOF MASS SPECTROMETRIES;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CLONIDINE; HALOPERIDOL; INORGANIC COMPOUND; KETOCONAZOLE; NANOMATERIAL; PAPAVERINE; PRAZOSIN; PROPRANOLOL; QUINIDINE; VERAPAMIL;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; HYDROPHOBICITY; INTERMETHOD COMPARISON; MASS SPECTROMETER; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NANOANALYSIS; PROCESS OPTIMIZATION; SAMPLING; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS;

EID: 56349155608     PISSN: 22110682     EISSN: 15402452     Source Type: Journal    
DOI: 10.1016/j.jala.2008.07.005     Document Type: Article

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