Keratinocytes enriched for epidermal stem cells differ in their response to IFN-γ from other proliferative keratinocytes

Experimental Dermatology

Volumn 17, Issue 12, 2008, Pages 998-1003

  Zeitvogel, Jana ^a   Werfel, Thomas ^a   Wittmann, Miriam ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Epidermal stem cells; Human; Inflammation

Indexed keywords

ALPHA6 INTEGRIN; BETA1 INTEGRIN; CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 18; MACROPHAGE DERIVED CHEMOKINE; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1;

ANTIGEN EXPRESSION; ARTICLE; CELL ADHESION; CELL CULTURE; CELL INTERACTION; CELL PROLIFERATION; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EPIDERMAL STEM CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; KERATINOCYTE; LYMPHOCYTIC INFILTRATION; STEM CELL;

ADULT STEM CELLS; ANTIGENS, CD29; CELL ADHESION; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINE CCL22; CHEMOKINE CXCL10; EPIDERMIS; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; INTEGRIN ALPHA6; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-18; KERATINOCYTES; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 56349143327     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2008.00735.x     Document Type: Article

References (41)

1. Barrandon Y, Green H. Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci U S A 1987: 84: 2302-2306.
2. Watt FM. Stem cell fate and patterning in mammalian epidermis. Curr Opin Genet Dev 2001: 11: 410-417.
3. Mackenzie IC, Bickenbach JR. Label-retaining keratinocytes and Langerhans cells in mouse epithelia. Cell Tissue Res 1985: 242: 551-556.
4. Lavker RM, Sun TT. Epidermal stem cells: Properties, markers, and location. Proc Natl Acad Sci U S A 2000: 97: 13473-13475.
5. Potten CS, Bullock JC. Cell kinetic studies in the epidermis of the mouse. I. Changes in labeling index with time after tritiated thymidine administration. Experientia 1983: 39: 1125-1129.
6. Li A, Simmons PJ, Kaur P. Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci U S A 1998: 95: 3902-3907.
7. Watt FM, Celso CL, Silva-Vargas V. Epidermal stem cells: An update. Curr Opin Genet Dev 2006: 16: 518-524.
8. Jones PH, Watt FM. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 1993: 73: 713-724.
9. Jensen UB, Lowell S, Watt FM. The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: A new view based on whole-mount labelling and lineage analysis. Development 1999: 126: 2409-2418.
10. Wan H, Stone MG, Simpson C et al. Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes. J Cell Sci 2003: 116: 4239-4248.
11. Kim DS, Cho HJ, Choi HR, Kwon SB, Park KC. Isolation of human epidermal stem cells by adherence and the reconstruction of skin equivalents. Cell Mol Life Sci 2004: 61: 2774-2781.
12. Bata-Csorgo Z, Hammerberg C, Voorhees JJ, Cooper KD. Kinetics and regulation of human keratinocyte stem cell growth in short-term primary ex vivo culture. Cooperative growth factors from psoriatic lesional T lymphocytes stimulate proliferation among psoriatic uninvolved, but not normal, stem keratinocytes. J Clin Invest 1995: 95: 317-327.
13. Wittmann M, Purwar R, Hartmann C, Gutzmer R, Werfel T. Human keratinocytes respond to interleukin-18: Implication for the course of chronic inflammatory skin diseases. J Invest Dermatol 2005: 124: 1225-1233.
14. Wittmann M, Alter M, Stunkel T, Kapp A, Werfel T. Cell-to-cell contact between activated CD4+T lymphocytes and unprimed monocytes interferes with a TH1 response. J Allergy Clin Immunol 2004: 114: 965-973.
15. Lajtha LG. Stem cell concepts. Differentiation 1979: 14: 23-34.
16. Fuchs E, Segre JA. Stem cells: A new lease on life. Cell 2000: 100: 143-155.
17. Pouliot N, Redvers RP, Ellis S, Saunders NA, Kaur P. Optimization of a transplant model to assess skin reconstitution from stem cell-enriched primary human keratinocyte populations. Exp Dermatol 2005: 14: 60-69.
18. Terunuma A, Kapoor V, Yee C, Telford WG, Udey MC, Vogel JC. Stem cell activity of human side population and alpha6 integrin-bright keratinocytes defined by a quantitative in vivo assay. Stem Cells 2007: 25: 664-669.
19. Triel C, Vestergaard ME, Bolund L, Jensen TG, Jensen UB. Side population cells in human and mouse epidermis lack stem cell characteristics. Exp Cell Res 2004: 295: 79-90.
20. Nickoloff BJ, Griffiths CE, Barker JN. The role of adhesion molecules, chemotactic factors, and cytokines in inflammatory and neoplastic skin disease -1990 update. J Invest Dermatol 1990: 94: 151S-157S.
21. Nickoloff BJ, Turka LA. Keratinocytes: Key immunocytes of the integument. Am J Pathol 1993: 143: 325-331.
22. Garioch JJ, Mackie RM, Campbell I, Forsyth A. Keratinocyte expression of intercellular adhesion molecule 1 (ICAM-1) correlated with infiltration of lymphocyte function associated antigen 1 (LFA-1) positive cells in evolving allergic contact dermatitis reactions. Histopathology 1991: 19: 351-354.
23. Gottlieb S, Hayes E, Gilleaudeau P, Cardinale I, Gottlieb AB, Krueger JG. Cellular actions of etretinate in psoriasis: Enhanced epidermal differentiation and reduced cell-mediated inflammation are unexpected outcomes. J Cutan Pathol 1996: 23: 404-418.
24. Griffiths CE, Nickoloff BJ. Keratinocyte intercellular adhesion molecule-1 (ICAM-1) expression precedes dermal T lymphocytic infiltration in allergic contact dermatitis (Rhus dermatitis). Am J Pathol 1989: 135: 1045-1053.
25. Okamoto S, Takahashi S, Inoue T et al. Cutaneous chronic graft-versus-host disease localized to the field of total lymphoid irradiation. Bone Marrow Transplant 1996: 17: 111-113.
26. Singer KH, Tuck DT, Sampson HA, Hall RP. Epidermal keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatory dermatoses. J Invest Dermatol 1989: 92: 746-750.
27. Dustin ML, Singer KH, Tuck DT, Springer TA. Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1). J Exp Med 1988: 167: 1323-1340.
28. Griffiths CE, Voorhees JJ, Nickoloff BJ. Gamma interferon induces different keratinocyte cellular patterns of expression of HLA-DR and DQ and intercellular adhesion molecule-I (ICAM-I) antigens. Br J Dermatol 1989: 120: 1-8.
29. Barker JN, Mitra RS, Griffiths CE, Dixit VM, Nickoloff BJ. Keratinocytes as initiators of inflammation. Lancet 1991: 337: 211-214.
30. Sligh JE Jr, Ballantyne CM, Rich SS et al. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A 1993: 90: 8529-8533.
31. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 1994: 76: 301-314.
32. Dustin ML, Springer TA. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 1989: 341: 619-624.
33. van Kooyk Y, van de Wiel-van Kemenade P, Weder P, Kuijpers TW, Figdor CG. Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature 1989: 342: 811-813.
34. Gaglia JL, Greenfield EA, Mattoo A, Sharpe AH, Freeman GJ, Kuchroo VK. Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells. J Immunol 2000: 165: 6091-6098.
35. Luksch CR, Winqvist O, Ozaki ME et al. Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells. Proc Natl Acad Sci U S A 1999: 96: 3023-3028.
36. Salomon B, Bluestone JA. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J Immunol 1998: 161: 5138-5142.
37. Smits HH, de Jong EC, Schuitemaker JH et al. Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development. J Immunol 2002: 168: 1710-1716.
38. Wittmann M, Werfel T. Interaction of keratinocytes with infiltrating lymphocytes in allergic eczematous skin diseases. Curr Opin Allergy Clin Immunol 2006: 6: 329-334.
39. Albanesi C, Scarponi C, Giustizieri ML, Girolomoni G. Keratinocytes in inflammatory skin diseases. Curr Drug Targets Inflamm Allergy 2005: 4: 329-334.
40. Barker JN, Sarma V, Mitra RS, Dixit VM, Nickoloff BJ. Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. J Clin Invest 1990: 85: 605-608.
41. Gutzmer R, Langer K, Mommert S, Wittmann M, Kapp A, Werfel T. Human dendritic cells express the IL-18R and are chemoattracted to IL-18. J Immunol 2003: 171: 6363-6371.