Reductions in motor unit number estimates (MUNE) precede motor neuron loss in the plasma membrane calcium ATPase 2 (PMCA2)-heterozygous mice

Experimental Neurology

Volumn 214, Issue 2, 2008, Pages 341-346

  Souayah, Nizar ^a   Sharovetskaya, Anna ^a   Kurnellas, Michael P ^a   Myerson, Matthew ^b   Deitch, Jeffrey S ^b   Elkabes, Stella ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Amyotrophic lateral sclerosis; ATPb2b; Calcium signaling; MUNE; Neurodegeneration; Spinal cord

Indexed keywords

CHOLINE ACETYLTRANSFERASE; PLASMA MEMBRANE CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ARTICLE; CELL COUNT; CELL LOSS; CONTROLLED STUDY; GRIP STRENGTH; HETEROZYGOTE; HINDLIMB; LUMBAR SPINAL CORD; MOTONEURON; MOTOR UNIT; MOTOR UNIT POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REDUCTION KINETICS; SENSORY DYSFUNCTION; SENSORY NERVE; SENSORY NERVE CONDUCTION; SPINAL CORD VENTRAL HORN; WILD TYPE;

ACTION POTENTIALS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; HAND STRENGTH; HETEROZYGOTE; MICE; MICE, MUTANT STRAINS; MOTOR NEURONS; NERVE DEGENERATION; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; SPINAL CORD;

EID: 56349106948     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.09.002     Document Type: Article

References (39)

1. Azzouz M., Leclerc N., Gurney M., Warter J.M., Poindron P., and Borg J. Progressive motor neuron impairment in an animal model of familial amyotrophic lateral sclerosis. Muscle Nerve 20 (1997) 45-51
2. Ballantyne J.P., and Hansen S. New method for the estimation of the number of motor units in a muscle. 2. Duchenne, limb-girdle and facioscapulohumeral, and myotonic muscular dystrophies. J. Neurol. Neurosurg. Psychiatry 37 (1974) 1195-1201
3. Bromberg M.B. Updating motor unit number estimation (MUNE). Clin. Neurophysiol. 118 (2007) 1-8
4. Brown W.F. Functional compensation of human motor units in health and disease. J. Neurol. Sci. 20 (1973) 199-209
5. Brown W.F., and Milner-Brown H.S. Some electrical properties of motor units and their effects on the methods of estimating motor unit numbers. J. Neurol. Neurosurg. Psychiatry 39 (1976) 249-257
6. Brown, R.H., Swash, M., and Pasinelli, P., 2006. Amyotrophic lateral sclerosis. Informa Healthcare; Distributed in North America by Taylor & Francis, Abingdon [England] Boca Raton, FL.
7. Burette A., Rockwood J.M., Strehler E.E., and Weinberg R.J. Isoform-specific distribution of the plasma membrane Ca2+ ATPase in the rat brain. J. Comp. Neurol. 467 (2003) 464-476
8. Cozzolino M., Ferri A., and Carri M.T. Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications. Antioxid. Redox Signal. 10 (2008) 405-443
9. Dantes M., and McComas A. The extent and time course of motoneuron involvement in amyotrophic lateral sclerosis. Muscle Nerve 14 (1991) 416-421
10. Eisen A., Karpati G., Carpenter S., and Danon J. The motor unit profile of the rat soleus in experimental myopathy and reinnervation. Neurology 24 (1974) 878-884
11. Empson R.M., Garside M.L., and Knopfel T. Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse. J. Neurosci. 27 (2007) 3753-3758
12. Feeney S.J., McKelvie P.A., Austin L., Jean-Francois M.J., Kapsa R., Tombs S.M., and Byrne E. Presymptomatic motor neuron loss and reactive astrocytosis in the SOD1 mouse model of amyotrophic lateral sclerosis. Muscle Nerve 24 (2001) 1510-1519
13. Felice K.J. A longitudinal study comparing thenar motor unit number estimates to other quantitative tests in patients with amyotrophic lateral sclerosis. Muscle Nerve 20 (1997) 179-185
14. Filoteo A.G., Elwess N.L., Enyedi A., Caride A., Aung H.H., and Penniston J.T. Plasma membrane Ca2+ pump in rat brain. Patterns of alternative splices seen by isoform-specific antibodies. J. Biol. Chem. 272 (1997) 23741-23747
15. Hadano S., Benn S.C., Kakuta S., Otomo A., Sudo K., Kunita R., Suzuki-Utsunomiya K., Mizumura H., Shefner J.M., Cox G.A., Iwakura Y., Brown Jr. R.H., and Ikeda J.E. Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking. Hum. Mol. Genet. 15 (2006) 233-250
16. Hansen S., and Ballantyne J.P. A quantitative electrophysiological study of motor neurone disease. J. Neurol. Neurosurg. Psychiatry 41 (1978) 773-783
17. Jillapalli D., and Shefner J.M. Single motor unit variability with threshold stimulation in patients with amyotrophic lateral sclerosis and normal subjects. Muscle Nerve 30 (2004) 578-584
18. Kozel P.J., Friedman R.A., Erway L.C., Yamoah E.N., Liu L.H., Riddle T., Duffy J.J., Doetschman T., Miller M.L., Cardell E.L., and Shull G.E. Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J. Biol. Chem. 273 (1998) 18693-18696
19. Kurnellas M.P., Nicot A., Shull G.E., and Elkabes S. Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury. FASEB J. 19 (2005) 298-300
20. Kurnellas M.P., Lee A.K., Li H., Deng L., Ehrlich D.J., and Elkabes S. Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons. Mol. Cell. Neurosci. 34 (2007) 178-188
21. Lehotsky J., Kaplan P., Racay P., Mezesova V., and Raeymaekers L. Distribution of plasma membrane Ca2+ pump (PMCA) isoforms in the gerbil brain: effect of ischemia-reperfusion injury. Neurochem. Int. 35 (1999) 221-227
22. McComas A.J., Fawcett P.R., Campbell M.J., and Sica R.E. Electrophysiological estimation of the number of motor units within a human muscle. J. Neurol. Neurosurg. Psychiatry 34 (1971) 121-131
23. McCullough B.J., and Tempel B.L. Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia. Hear. Res. 195 (2004) 90-102
24. Milner-Brown H.S., and Brown W.F. New methods of estimating the number of motor units in a muscle. J. Neurol. Neurosurg. Psychiatry 39 (1976) 258-265
25. Nicot A., Ratnakar P.V., Ron Y., Chen C.C., and Elkabes S. Regulation of gene expression in experimental autoimmune encephalomyelitis indicates early neuronal dysfunction. Brain 126 (2003) 398-412
26. Reaume A.G., Elliott J.L., Hoffman E.K., Kowall N.W., Ferrante R.J., Siwek D.F., Wilcox H.M., Flood D.G., Beal M.F., Brown Jr. R.H., Scott R.W., and Snider W.D. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat. Genet. 13 (1996) 43-47
27. Rowland L.P., and Shneider N.A. Amyotrophic lateral sclerosis. N. Engl. J. Med. 344 (2001) 1688-1700
28. Shefner J.M. Motor unit number estimation in human neurological diseases and animal models. Clin. Neurophysiol. 112 (2001) 955-964
29. Shefner J.M., Reaume A.G., Flood D.G., Scott R.W., Kowall N.W., Ferrante R.J., Siwek D.F., Upton-Rice M., and Brown Jr. R.H. Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy. Neurology 53 (1999) 1239-1246
30. Shefner J.M., Brown Jr. R.H., Cole D., Chaturvedi P., Schoenfeld D., Pastuszak K., Matthews R., Upton-Rice M., and Cudkowicz M.E. Effect of neurophilin ligands on motor units in mice with SOD1 ALS mutations. Neurology 57 (2001) 1857-1861
31. Shefner J.M., Cudkowicz M.E., and Brown Jr. R.H. Comparison of incremental with multipoint MUNE methods in transgenic ALS mice. Muscle Nerve 25 (2002) 39-42
32. Shefner J.M., Cudkowicz M., and Brown Jr. R.H. Motor unit number estimation predicts disease onset and survival in a transgenic mouse model of amyotrophic lateral sclerosis. Muscle Nerve 34 (2006) 603-607
33. Shull G.E., Okunade G., Liu L.H., Kozel P., Periasamy M., Lorenz J.N., and Prasad V. Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants. Ann. N.Y. Acad. Sci. 986 (2003) 453-460
34. Stahl W.L., Eakin T.J., Owens Jr. J.W., Breininger J.F., Filuk P.E., and Anderson W.R. Plasma membrane Ca(2+)-ATPase isoforms: distribution of mRNAs in rat brain by in situ hybridization. Brain Res. Mol. Brain Res. 16 (1992) 223-231
35. Stauffer T.P., Guerini D., and Carafoli E. Tissue distribution of the four gene products of the plasma membrane Ca2+ pump. A study using specific antibodies. J. Biol. Chem. 270 (1995) 12184-12190
36. Stauffer T.P., Guerini D., Celio M.R., and Carafoli E. Immunolocalization of the plasma membrane Ca2+ pump isoforms in the rat brain. Brain Res. 748 (1997) 21-29
37. Street V.A., McKee-Johnson J.W., Fonseca R.C., Tempel B.L., and Noben-Trauth K. Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice. Nat. Genet. 19 (1998) 390-394
38. Strehler E.E., and Zacharias D.A. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol. Rev. 81 (2001) 21-50
39. Strehler E.E., Filoteo A.G., Penniston J.T., and Caride A.J. Plasma-membrane Ca(2+) pumps: structural diversity as the basis for functional versatility. Biochem. Soc. Trans. 35 (2007) 919-922