Gene expression profiling of human hibernating myocardium: Increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart

European Journal of Heart Failure

Volumn 10, Issue 12, 2008, Pages 1177-1180

  Prasad, Sanjay K ^a,b   Clerk, Angela ^a   Cullingford, Timothy E ^a   Chen, Alexander W Y ^a   Kemp, Timothy J ^a   Cannell, Timothy M ^b   Cowie, Martin R ^a   Petrou, Mario ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Genes; Hibernation; Myocardium; Natriuretic peptides

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; FOLLISTATIN; PROENKEPHALIN;

ARTICLE; BYPASS SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; DNA FINGERPRINTING; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HEART CONTRACTION; HEART FAILURE; HEART MUSCLE BIOPSY; HUMAN; HUMAN TISSUE; MICROARRAY ANALYSIS; MYOCARDIAL HIBERNATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; STABLE ANGINA PECTORIS;

ANGINA PECTORIS; ATRIAL NATRIURETIC FACTOR; ENKEPHALINS; FOLLISTATIN-RELATED PROTEINS; GENE EXPRESSION PROFILING; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIUM; NATRIURETIC PEPTIDE, BRAIN; PROTEIN PRECURSORS; RNA, MESSENGER; VENTRICULAR FUNCTION, LEFT;

EID: 56349088836     PISSN: 13889842     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejheart.2008.08.008     Document Type: Article

References (16)

1. Depre C., and Vatner S.F. Mechanisms of cell survival in myocardial hibernation. Trends Cardiovasc Med 15 (2005) 101-110
2. Camici P.G., and Rimoldi O.E. The contribution of hibernation to heart failure. Ann Med 36 (2004) 440-447
3. Kim R.J., Wu E., Rafael A., et al. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med 343 (2000) 1445-1453
4. Underwood S.R., Bax J.J., vom Dahl J., et al. Imaging techniques for the assessment of myocardial hibernation. Report of a Study group of the European Society of Cardiology. Eur Heart J 25 (2004) 815-836
5. Elsasser A., Vogt A.M., Kostin S., et al. Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death. J Am Coll Cardiol 43 (2004) 2191-2199
6. Depre C., Kim S.-J., John A.S., et al. Program of cell survival underlying human and experimental hibernating myocardium. Circ Res 95 (2004) 433-440
7. Depre C., Tomlinson J.E., Kudeh R.K., et al. Gene program for cardiac cell survival induced by transient ischemia in conscious pigs. Proc Natl Acad Sci U S A 98 (2001) 9336-9341
8. 2 in cardiac myocytes. Biochem Biophys Res Commun 307 (2003) 416-421
9. Margulies K.B., Matiwala S., Cornejo C., Olsen H., Craven W.A., and Bednarik D. Mixed messages: transcription patterns in failing and recovering human myocardium. Circ Res 96 (2005) 592-599
10. Chen Y., Park S., Li Y., et al. Alterations of gene expression in failing myocardium following left ventricular assist device support. Physiol Genomics 14 (2003) 251-260
11. Birks E.J., Hall J.L., Barton P.J.R., et al. Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support. Circulation 112 (2005) 57-64
12. Kittleson M.M., and Hare J.M. Molecular signature analysis: using the myocardial transcriptome as a biomarker in cardiovascular disease. Trends Cardiovasc Med 15 (2005) 130-138
13. Sharma U.C., Pokharel S., Evelo C.T., and Maessen J.G. A systematic review of large scale and heterogeneous gene array data in heart failure. J Mol Cell Cardiol 38 (2005) 425-432
14. McCarthy J.J., Parker A., Salem R., et al. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. J Med Genet 41 (2004) 334-341
15. Kragelund C., Gronning B., Kober L., Hildebrandt P., and Steffensen R. N-terminal pro-B-type natriuretic peptide and long-term mortality in stable coronary heart disease. N Engl J Med 352 (2005) 666-675
16. Ndrepepa G., Braun S., Niemoller K., et al. Prognostic value of N-terminal pro-brain natriuretic peptide in patients with chronic stable angina. Circulation 112 (2005) 2102-2107