Bromelain: An overview

Indian Journal of Natural Products and Resources

Volumn 7, Issue 4, 2008, Pages 359-363

  Bhattacharyya, Barun K ^a  

^a East India Pharmaceutical Works Limited Quality Control Department   (India)

Author keywords

Ananas comosus; Bromelain; Phytotherapeutic; Pineapple plant; Proteinase

Indexed keywords

ANANAS COMOSUS;

EID: 56249148845     PISSN: 09760504     EISSN: 09760512     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Rowan AD, Buttle DJ and Barrett AJ, The cysteine proteinases of the pineapple plant, Biochem J, 1990, 226, 869-875.
2. Kelly GS, Bromelain: A literature review and discussion of its therapeutic application, Alt Med Rev, 1996, 1(4), 243-267.
3. Izaka K, Yamada M, Kawano T and Suyama T, Gastrointestinal absorption and anti-inflammatory effect of bromelain, Jap J Pharmacol, 1972, 22, 519-534.
4. Maurer HR, Bromelain: Biochemistry, pharmacology and medicinal use, CMLS Cell Mol Life Sci, 2001, 58, 1234-1245.
5. Bogre L, Ligerink W, Hebele-Bros E and Hirt H, Mechanosensors in plants, Nature, 1996, 383, 489-490.
6. Taussig SJ and Nieper HA, Bromelain: its use in prevention and treatment of cardiovascular diseases, present status, JIAPM, 1979, 6, 139-151.
7. Harrach T, Eckert K, Schulze-Forster K, Nuck R, Grunow D and Maurer HR, Isolation and partial characterization of basic proteinases from stem bromelain, J Protein Chem, 1995, 14, 41-52.
8. Jeung A, In: Encyclopedia of common natural ingredients used in foods, drugs and cosmetics, John Wiley & Sons, New York, 1980, pp. 74-76.
9. Cooreman W, Bromelain, In: Pharmaceutical Enzyme Properties and Assay Methods, R Ruyssen and A Lauwers (Eds), E Story-Scienta Scientific Publishing Co. Gent/ Belgium, 1978, pp. 107-121.
10. Hatano K, Kojiam M, Tanokura M and Takahashi K, Solution structure of bromelain inhibitor VI from pineapple stem: Structural similarity with Bowman-Birk trypsin/ chymotrysin inhibitor from soybean, Biochemistry, 1996, 35, 5379-5384.
11. Filipova Y, Lysogorskaya EN, Oksenoit ES, Rudenskaya GN and Stepanov VM, L-Pyroglutamyl-L-Phenylalanyl-L-Leucine-PNitroanilide– a chromogenic substance for thiol proteinase assay, Anal Biochem, 1984, 143, 293-297.
12. Inagami T and Murachi T, Kinetic studies of bromelain catalysis, Biochemistry, 1963, 2, 1439-1444.
13. Brocklehurst K, Crook EM and Kierstan M, The mutability of stem bromelain: evidence for perturbation by structural transitions of the parameters that characterize the reaction of the essential thiol group of bromelain with 2,2'-dipyridyl disulphide, Biochem J, 1972, 128(4), 979-982.
14. Wharton Christopher W, Cornish-Bowden Athel, Brocklehurst Keith and Crook Eric, Kinetics of the hydrolysis of N-benzoyl-l-serine methyl ester catalysed by bromelain and by papain. Analysis of modifier mechanisms by lattice nomography, computational methods of parameter evaluation for substrate-activated catalyses and consequences of postulated non-productive binding in bromelain- and papain-catalysed hydrolyses, Biochem J, 1974, 141(2), 365-381.
15. White RR, Crawley FE, Vellini M and Rovati LA, Bioavailability of 125I bromelain after oral administration to rats, Biopharm Drug Dispos, 1988, 9, 397-403.
16. Seifert J, Ganser R and Brendel W, Absorption of a proteolytic enzyme of plant origin from the gastrointestinal tract into the blood and lymph of adult rats, J Gastroent, 1979, 17, 1-18.
17. Castell JV, Intestinal absorption of undegraded bromelain in humans, In: Absorption of orally administered enzymes, MLG Gardner and KJ Steffens (Eds), Springer, Berlin, 1995, pp. 16, 47-60.
18. Heinicke RM, Van der Wal M and Yokoyama MM, Effect of bromelain on human platelet aggregation, Experientia, 1972, 28, 844-845.
19. Morita AH, Uchida DA and Taussng SJ, Chromatographic fractionation and characterization of the active platelet aggregation inhibitory factor from bromelain, Arch Int Pharm Ther, 1979, 239, 240-350.
20. Metzig C, Grabowska E, Eckert K, Rehse K and Maurer HR, Bromelain proteases reduces human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo, In Vivo, 1999, 13(1), 7-12.
21. Livio M, De Gaetano G and Donati M B, Effect of bromelain on fibrinogen level, prothrombin complex factors and platelet aggregation in rat – A preliminary report, Drugs Exp Clin Res, 1978, 4, 49-53.
22. De-Giuli M and Pirotta F, Bromelain, interaction with some protease inhibitor and rabbit specific antiserum, Drugs Exp Clin Res, 1978, 4, 21-23.
23. Inoue K, Motonaga A, Dainaka J, Nishimura T, Hashii H, Yamate K, Ueda F and Klmura K, Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation, Prostaglandins Leukot Essent Fatty Acids, 1994, 51, 457-462.
24. Leipner J, Iten F and Saller R, Therapy with proteolytic enzymes in rheumatic disorders, Biol Drugs, 2001, 15(12), 779-789.
25. Seltzer AP, Minimizing post operative edema and ecchymoses by the use of an oral enzyme preparation (bromelain), EENT Monthly, 1962, 41, 813-817.
26. Oh-Ishi Sachiko, Yasuhiro Uchida, Akinori Ueno and Makoto Katori, Bromelain, a thiolprotease from pineapple stem, depletes high molecular weight kininogen by activation of Hageman factor (factor XII), Thrombosis Res,1979, 14(4-5), 665-672.
27. Vellini M, Desideri D, Milanese A, Omini C, Daffonchio L, Hernandez A and Brunelli G, Possible involvement of eicosanoids in pharmacological action of bromelain, Arzneim-Forch/Drug Res, 1986, 36, 110-112.
28. Munzig E, Eckert K, Harrach T, Graf H and Maurer HR, Bromelain protease F9 reduces the CD44 mediated adhesions of human peripheral blood lymphocytes to human umbilical vein endothelial cells, FEBS Lett, 1994, 351, 215-218.
29. Desser L and Rehberger A, Introduction of tumor necrosis factor in human peripheral blood mononuclear cells by proteolytic enzymes, Oncology, 1990, 47, 475-477.
30. Desser L, Rehberger A, Harrach T and Paukovits W, Bromelain protease F9 reduces the CD44 mediated adhesion of human peripheral blood lymphocytes to human umbilical vein endothelial cells, FEBS Lett, 1995, 351, 215-218.
31. Moss JN, Frazier CV and Martin GJ, Bromelains: The pharmacology of the enzymes, Arch Int Pharmacodyn, 1963, 145, 166-189.
32. Tinozzi S and Venegoni A, Effect of bromelain on serum and tissue levels of amoxicillin, Drugs Exp Clin Res, 1978, 4, 39-44.
33. Knill-Jones RP, Pearce H, Batten J and Williams R, Comparative trial of Nutrizyme in chronic pancreatic insufficiency, Br Med J, 1970, 4, 21-24.
34. Seligman B, Bromelain an anti-inflammatory agent, Angiology, 1962, 13, 508-510.
35. Taussig SJ and Nieper HA, Bromelain: its use in prevention and treatment of cardiovascular diseases present status, Hiv J Med Sci, 1979, 24, 185-193.
36. Giacca S, Clinical experiments with bromelain in pheripheral venous diseases and chronic bronchitic states, Minerva Med, 1965, 56 (Suppl), 104.
37. Nieper HA, Effect of bromelain on coronary heart disease and angina pectoris, Acta Med Empirica, 1978, 5, 274-278.
38. Hauck JC, Chang CM and Klein G, Isolation of an effective debriding agent from the stems of pineapple plants, Int J Tissue React, 1983, 5, 125-134.
39. Eckert K, Grabowska E, Stange R, Schneider U and Maurer HR, Effects of oral bromelain administration on the impaired immunotoxicity of mononuclear cells from breast cancer patients, Oncol Rep, 1999, 6, 1191-1199.