VEGF, COX-2, and PCNA expression in renal cell carcinoma subtypes and their prognostic value

International Urology and Nephrology

Volumn 40, Issue 4, 2008, Pages 861-868

  Dirim, Ayhan ^a   Haberal, Asuman Nihan ^a   Goren, Mehmet Resit ^a   Tekin, Mehmet Ilteris ^a   Peskircioglu, Levent ^a   Demirhan, Beyhan ^a   Ozkardes, Hakan ^a  

^a BASKENT UNIVERSITY   (Turkey)

Author keywords

COX 2; PCNA; Prognostic factors; Renal cell carcinoma; VEGF

Indexed keywords

CYCLINE; CYCLOOXYGENASE 2; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER STAGING; CLEAR CELL CARCINOMA; CORRELATION ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; MIXED TUMOR; NEPHRECTOMY; PAPILLARY CARCINOMA; PROGNOSIS; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; VASCULAR INVASION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; CYCLOOXYGENASE 2; DISEASE PROGRESSION; FEMALE; HUMANS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEPHRECTOMY; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 56249146324     PISSN: 03011623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11255-008-9362-7     Document Type: Article

References (35)

1. Cho DS, Joo HJ, Oh DK et al (2005) Cyclooxygenase-2 and p53 expression as prognostic indicators in conventional renal cell carcinoma. Yonsei Med J 46:133-140
2. Delahunt B (1998) Histopathologic prognostic indicators for renal cell carcinoma. Semin Diagn Pathol 15:68-76 (Review)
3. Yasunaga Y, Shin M, Miki T et al (1998) Prognostic factors of renal cell carcinoma: A multivariate analysis. J Surg Oncol 68:11-18
4. Yokogi H (1996) Flow cytometric quantitation of the proliferation-associated nuclear antigen p105 and DNA content in patients with renal cell carcinoma. Cancer 78:819-826
5. Weidner N, Semple JP, Welch WR et al (1991) Tumor angiogenesis and metastasis correlation in invasive breast carcinoma. N Engl J Med 324:1-8
6. Bates DO, Cui TG, Doughty JM et al (2002) VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. Cancer Res 62:4123-4131
7. Gerber HP, Hillan KJ, Ryan AM et al (1999) VEGF is required for growth and survival in neonatal mice. Development 126:1149-1159
8. Carmeliet P, Collen D (2000) Transgenic mouse models in angiogenesis and cardiovascular disease. J Pathol 190:387-405
9. Nicol D, Hii SI, Walsh M et al (1997) Vascular endothelial growth factor expression is increased in renal cell carcinoma. J Urol 157:1482-1486
10. Gallo O, Masini E, Bianchi B et al (2002) Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. Hum Pathol 33:708-714
11. Chen Q, Shinohara N, Abe T et al (2004) Significance of COX-2 expression in human renal cell carcinoma cell lines. Int J Cancer 108:825-832
12. DeWitt D, Smith WI (1995) Yes, but do they still get headaches? Cell 83:345-348
13. Ristimaki A, Nieminen O, Saukkonen K et al (2001) Expression of cyclooxygenase-2 in human transitional cell carcinoma of the urinary bladder. Am J Pathol 158:849-853
14. Hall PA, Levison DA, Woods AL et al (1990) Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 162:285-294
15. Warbrick E (2000) The puzzle of PCNA's many partners. Bioassays 22:997-1006
16. Waseem NH, Lane DP (1990) Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conversion and the detection of a nucleolar form. J Cell Sci 90:121-125
17. Sobin LH, Wittekind CH (1997) International Union Against Cancer (UICC). TNM classification of malignant tumours, 5th edn. Wiley-Liss, New York
18. Fuhrman SA, Lasky LC, Limas C (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6:655-663
19. Kovacs G, Akhtar M, Beckwith BJ et al (1997) The Heidelberg classification of renal cell tumours. J Pathol 183:131-133 (Review)
20. Jacobsen J, Rasmuson T, Grankvist K et al (2000) Vascular endothelial growth factor as prognostic factor in renal cell carcinoma. J Urol 163:343-347
21. Jacobsen J, Grankvist K, Rasmuson T et al (2004) Expression of vascular endothelial growth factor protein in human renal cell carcinoma. BJU Int 93:297-302
22. Ljungberg B, Jacobsen J, Haggstrom-Rudolfssson S et al (2003) Tumour vascular endothelial growth factor (VEGF) mRNA in relation to serum VEGF protein levels and tumour progression in human renal cell carcinoma. Urol Res 31:335-340
23. Miyata Y, Koga S, Kanda S et al (2003) Expression of cyclooxygenase-2 in renal cell carcinoma: Correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival. Clin Cancer Res 9:1741-1749
24. Yoshimura R, Matsuyama M, Kawahito Y et al (2004) Study of cyclooxygenase-2 in renal cell carcinoma. Int J Mol Med 13:229-233
25. Leahy KM, Koki AT, Masferrer JL (2000) Role of cyclooxygenases in angiogenesis. Curr Med Chem 7:1163-1170 (Review)
26. Fosslien E (2001) Molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. Ann Clin Lab Sci 31:325-348 (Review)
27. Fosslien E (2000) Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Crit Rev Clin Lab Sci 37:431-502
28. Fosslien E (2000) Molecular pathology of cyclooxygenase-2 in neoplasia. Ann Clin Lab Sci 30:3-21
29. Rini BI, Weinberg V, Dunlap S et al (2006) Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma. Cancer 106:566-575
30. Hashimoto Y, Kondo Y, Kimura G et al (2004) Cyclooxygenase-2 expression and relationship to tumour progression in human renal cell carcinoma. Histopathology 44:353-359
31. Shameem IA, Shimabukuro T, Wada T et al (1996) Expression of proliferating cell nuclear antigen and deoxyribonucleic acid value in renal cell carcinoma: Correlation with different histopathological parameters and patient survival. Eur Urol 29:78-84
32. Larsson P, Roos G, Stenling R et al (1996) Proliferating cell nuclear antigen expression in renal cell carcinoma. Prognostic implications. Scand J Urol Nephrol 30:445-450
33. Delahunt B, Bethwaite PB, Nacey JN et al (1993) Proliferating cell nuclear antigen (PCNA) expression as a prognostic indicator for renal cell carcinoma: Comparison with tumour grade, mitotic index, and silver-staining nucleolar organizer region numbers. J Pathol 170:471-477
34. Cronin KJ, Williams NN, Kerin MJ et al (1994) Proliferating cell nuclear antigen: A new prognostic indicator in renal cell carcinoma. J Urol 152:834-836
35. Fischer C, Georg C, Kraus S et al (1999) CD44s, E-cadherin and PCNA as markers for progression in renal cell carcinoma. Anticancer Res 19:1513-1517