Development and validation of a rapid, sensitive liquid chromatography-tandem mass spectrometry method using electrospray ionization for quantitation of centchroman in rat plasma and its application to preclinical pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 876, Issue 1, 2008, Pages 1-7

  Singh, Sheelendra Pratap ^a   Singh, Ravi Shankar Prasad ^a   Wahajuddin, ^a   Jain, Girish Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Centchroman; LC MS MS; Pharmacokinetics; Rat plasma; Validation

Indexed keywords

ACETONITRILE; AMMONIUM COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; CONCENTRATION (PROCESS); CORRELATION METHODS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; EXTRACTION; HEXANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); PLASMAS; SOLVENT EXTRACTION;

AMMONIUM ACETATES; CENTCHROMAN; CORRELATION COEFFICIENTS; FREEZE/THAW CYCLES; HIGHLY SENSITIVES; INTERNAL STANDARDS; ISO PROPANOLS; LC-MS/MS; LINEARITY RANGES; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRIES; LIQUID EXTRACTIONS; MATRIX EFFECTS; ORAL ADMINISTRATIONS; PHARMACOKINETIC PARAMETERS; PHARMACOKINETIC STUDIES; PLASMA CONCENTRATIONS; RAT PLASMA; RAT PLASMAS; RUN TIMES; STABILITY STUDIES; SUPELCO; TAMOXIFEN; VALIDATION;

PLASMA STABILITY;

2 PROPANOL; ACETONITRILE; AMMONIUM ACETATE; CENTCHROMAN; HEXANE; TAMOXIFEN;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; NONHUMAN; PH; PLASMA; PRIORITY JOURNAL; RAT; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STANDARD; TANDEM MASS SPECTROMETRY; TEMPERATURE;

ANIMALS; CENTCHROMAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; FEMALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 56249137535     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.09.039     Document Type: Article

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