Therapy directed against thymic stromal lymphopoietin

Drug News and Perspectives

Volumn 21, Issue 6, 2008, Pages 312-316

  Edwards, Matthew J ^a  

^a Respiratory Disease TA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; INTERLEUKIN 13 ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 4 ANTIBODY; INTERLEUKIN 5 ANTIBODY; INTERLEUKIN 7; THYMIC STROMAL LYMPHOPOIETIN; THYMIC STROMAL LYMPHOPOIETIN ANTAGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ALLERGIC INFLAMMATION; ALLERGIC REACTION; ARTICLE; ATOPIC DERMATITIS; CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; IMMUNE RESPONSE; LUNG ALVEOLUS EPITHELIUM; MAST CELL; NONHUMAN; PATENT; PSORIASIS; SKIN BIOPSY; TH1 CELL; TH2 CELL;

ANIMALS; ANTI-ALLERGIC AGENTS; ANTI-ASTHMATIC AGENTS; ASTHMA; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DENDRITIC CELLS; EPITHELIAL CELLS; HUMANS; HYPERSENSITIVITY; SIGNAL TRANSDUCTION;

EID: 56249128993     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2008.21.6.1246830     Document Type: Article

References (20)

1. Lambrecht, B.N. Dendritic cells and the regulation of the allergic immune response. Allergy 2005, 60(3): 271-82.
2. Liu, Y.J. Thymic stromal lymphopoietin: master switch for allergic inflammation. J Exp Med 2006, 203(2): 269-73.
3. Park, L.S., Martin, U., Garka, K. et al. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med 2000, 192(5): 659-70.
4. Quentmeier, H., Drexler, H.G., Fleckenstein, D., Zaborski, M., Armstrong, A., Sims, J.E. and Lyman, S.D. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia 2001, 15(8): 1286-92,
5. Reche, P.A., Soumelis, V., Gorman, D.M. et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol 2001 167(1): 336-43.
6. Soumelis, V., Reche, P.A., Kanzler, H. et al. Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP. Nat Immunol 2002, 3(7): 673-80.
7. Ito, T., Wang, Y.H., Duramad, O. et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 2005, 202(9):1213-23.
8. Watanabe, N., Hanabuchi, S., Soumelis, V., Yuan, W., Ho, S., de Waal, M.R. and Liu, Y.J. Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion. Nat Immunol 2004, 5(4): 426-34.
9. Allakhverdi, Z., Comeau, M.R., Jessup, H.K. et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med 2007, 204(2): 253-8.
10. Kato, A., Favoreto, S. Jr., Avila, P.C. and Schleimer, R.P. TLR3- and Th2 cytokine dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol 2007, 179(2): 1080-7.
11. Message, S.D. and Johnston, S.L. Viruses in asthma: The role of viruses in childhood respiratory infections. Br Med Bull 2002, 61(1): 29-43.
12. Wang, Y.H., Ito, T., Wang, Y.H. et al. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity 2006, 24(6): 827-38.
13. Rochman, I., Watanabe, N., Arima, K., Liu, Y.J. and Leonard, W.J. Cutting edge: Direct action of thymic stromal lymphopoietin on acii. vated human CD4+ T cells. J Immunol 2007, 178(11): 6720-4.
14. Bogiatzi, S.I., Fernandez, I., Bichet, J.C., Marloie-Provost, M.A., Volpe, E., Sastre, X. and Soumelis, V. Cutting edge: Proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes. J Immunol 2007, 178(6): 3373-7.
15. Yoo, J., Omori, M., Gyarmati, D. et al. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med 2005, 202(4): 541-9.
16. Li, M., Messaddeq, N., Teletin, M., Pasquali, J.-L., Metzger, D. and Chambon, P. Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A 2005, 102(41): 14795-800.
17. Ying, S., O'Connor, B., Ratoff, J. et al. Thymic stromal lymphopoietin expression is i. nereased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005, 174(12): 9183-90.
18. Zhou, B., Comeau, M.R., De, S.T. et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 2005, 6(10): 1047-53.
19. Al-Shami, A., Spolski, R., Kelly, J., Keane-Myers, A. and Leonard, W.J. A role for TSLP in the development of inflammation in an asthma model. J Exp Med 2002, 202(6): 829-39.
20. Shamim, Z., Muller, K., Svejgaard, A., Poulsen, L.K., Bodtger, U. and Ryder, L.P. Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy. Int J Immunogenet 2007, 34(3): 149-51.