Neuronal apoptosis and expression of caspase-12 mRNA and protein following focal cerebral ischemia-reperfusion in rats

Chinese Pharmacological Bulletin

Volumn 24, Issue 8, 2008, Pages 1069-1072

  Zhang, Hong ^a   Song, Li Chun ^a   Jia, Chun Hong ^a   Liu, Yan Yan ^b   Lü, Yong Li ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Department of Internal Medicine   (China)

Author keywords

Apoptosis; Caspase 12; Cerebral ischemia; Endoplasmic reticulum

Indexed keywords

CASPASE 12; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WISTAR RAT;

EID: 56249126485     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Paschen W. Endoplasmic reticulum dysfunction in brain pathology: critical role of protein synthesis[J]. Curr Neurovasc Res, 2004, 1 (2):173-81.
2. Nagasawa H, Kogure K. Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion[J]. Stroke,1989,20(8):1037-43.
3. Shi J, Yang S H, Stubley L, et al. Hypoperfusion induces overexpression of β-amyloid precursor protein mRNA in a focal ischemic rodent model[J]. Brain Res,2000,853(1):1-4.
4. Charriaut-Marlangue C, Margall I, Reprosa A, et al. Apoptosis and necrosis after reversible focal ischemia and in situ DNA fragmentation analysis[J]. J Cereb Blood Flow Metab,1996,16(2):186-94.
5. Wang J S, Qiu Z Y, Xia Y P, et al. Effects of total glucosides of Rubus parviflolius L(TGRP) on neuronal apoptosis and expression of apoptosis related protein Bcl-2 and Bax in rat after local cerebral ischemic-reperfusion[J]. Chin Pharmacol Bull,2006,22(2):224-8.
6. Li H, Deng C Q, Chen B Y, et al. Effects of Panax Notoginseng Saponins on expression of Caspase after focal cerebral ischemia-reperfusion in rats[J]. Chin Pharmacol Bull,2006,22(2):189-93.
7. Zhang H, Song L C, Liu Y Y, et al. Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways[J]. Neurosci Bull,2007,23(3):145-50.
8. Feng L J, Wang H Q, Shen Y X, et al. ER stress involves in neuronal degeneration[J]. Chin Pharmacol Bull,2007,23(4):428-32.
9. Morishima N, Nakanishi K, Takenouchi H, et al. An endoplasmic reticulum stress-specific caspase cascade in apop tosis. Cytochrome c-independent activation of caspase-9 by caspase-12[J]. J Biol Chem,2002,277(37):34287-94.
10. Shibata M, Hattori H, Sasaki T, et al. Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice[J]. Neuroscience,2003,118(2):491-9.
11. Mouw G, Zechel J L, Gamboa J, et al. Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat[J]. Neuroreport,2003,14(2):183-86.
12. Xu C, Bailly-Maitre B, Reed J C. Endoplasmic reticulum stress: cell life and death decisions[J]. J Clin Invest,2005,115(10): 2656-64.
13. Hayashi T, Saito A, Okuno S, et al. Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurins[J]. J Cereb Blood Flow Metab,2005,25(1):41-53.