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O'Hanlon TP, Carrick DM, Targoff IN, et al. Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. Medicine (Baltimore) 2006; 85:111-127.
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Targoff IN, Arnett FC, Reichlin M. Antibody to threonyl-transfer RNA synthetase in myositis sera. Arthritis Rheum 1988; 31:515-524.
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Reaction of anti-OJ autoantibodies with components of the multienzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase
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Targoff IN, Trieu EP, Miller FW. Reaction of anti-OJ autoantibodies with components of the multienzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase. J Clin Invest 1993; 91:2556-2564.
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Identification of auto-antibodies to tyrosyl-tRNA synthetase in dermatomyositis with features consistent with antisynthetase syndrome [abstract]
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Hashish L, Trieu EP, Sadanandan P, Targoff IN. Identification of auto-antibodies to tyrosyl-tRNA synthetase in dermatomyositis with features consistent with antisynthetase syndrome [abstract]. Arthritis Rheum 2005; 52:S312.
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A novel autoantibody to a 155-kd protein is associated wtth dermatomyositis
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Targoff IN, Mamyrova G, Trieu EP, et al. A novel autoantibody to a 155-kd protein is associated wtth dermatomyositis. Arthritis Rheum 2006; 54:3682-3689.
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Targoff, I.N.1
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25
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33845596457
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Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: An association with malignancy
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Kaji K, Fujimoto M, Hasegawa M, et al. Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy. Rheumatology (Oxford) 2007; 46:25-28.
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Kaji, K.1
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26
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34848858291
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Identification of a novel autoantibody directed against small ubiquitin-like modifier activating enzyme in dermatomyositis
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Novel autoantibodies targeting small ubiquitin-like modifier enzyme, a protein involved in post-translational modification, are described in dermatomyositis
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Betteridge Z, Gunawardena H, North J, et al. Identification of a novel autoantibody directed against small ubiquitin-like modifier activating enzyme in dermatomyositis. Arthritis Rheum 2007; 56:3132-3137. Novel autoantibodies targeting small ubiquitin-like modifier enzyme, a protein involved in post-translational modification, are described in dermatomyositis.
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Arthritis Rheum
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Betteridge, Z.1
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Betteridge Z, Gunawardena H, Chinoy H, et al. Clinical and immunogenetic associations of anti-SAE autoantibodies in patients with dermatomyositis [abstract]. Rheumatology (Oxford) 2008; 47:S2ii85.
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Betteridge Z, Gunawardena H, Chinoy H, et al. Clinical and immunogenetic associations of anti-SAE autoantibodies in patients with dermatomyositis [abstract]. Rheumatology (Oxford) 2008; 47:S2ii85.
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28
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34548566557
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The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis
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This study described the diagnostic utility of autoantibody testing, in particular anti-p155/140 in the prediction of CAM
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Chinoy H, Fertig N, Oddis CV, et al. The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis. Ann Rheum Dis 2007; 66:1345-1349. This study described the diagnostic utility of autoantibody testing, in particular anti-p155/140 in the prediction of CAM.
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Chinoy, H.1
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Clinical associations of anti-p155/140 autoantibodies in adult and juvenile dermatomyositis [abstract]
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Anti-p155/140 is a major myositis-specific autoantibody in juvenile dermatomyositis and the clinical specificity is described
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Gunawardena H, Wedderburn LR, North J, et al. Juvenile Dermatomyositis Research Group UK. Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis. Rheumatology (Oxford) 2008; 47:324-328. Anti-p155/140 is a major myositis-specific autoantibody in juvenile dermatomyositis and the clinical specificity is described.
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Rheumatology (Oxford)
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Gunawardena, H.1
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North, J.3
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31
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Autoantibodies to transcriptional intermediary factor 1-gamma (TIF1-g) in dermatomyositis [abstract]
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Targoff IN, Trieu EP, Levy-Neto M, et al. Autoantibodies to transcriptional intermediary factor 1-gamma (TIF1-g) in dermatomyositis [abstract]. Arthritis Rheum 2006; 54:S518.
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Targoff IN, Trieu EP, Levy-Neto M, et al. Sera with autoantibodies to the MJ antigen react with NXP2 [abstract]. Arthritis Rheum 2007; 56:S787.
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Eloranta ML, Barbasso Helmers S, Ulfgren AK, et al. A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies. Arthritis Rheum 2007; 56:3112-3124. MSAs may play a role in disease pathogenesis. This work showed that sera positive for anti-Jo-1 and/or anti-Ro52/Ro60 can induce IFN production by peripheral blood mononuclear cells in vitro. Markers of IFN production were increased in myositis muscle.
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Eloranta ML, Barbasso Helmers S, Ulfgren AK, et al. A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies. Arthritis Rheum 2007; 56:3112-3124. MSAs may play a role in disease pathogenesis. This work showed that sera positive for anti-Jo-1 and/or anti-Ro52/Ro60 can induce IFN production by peripheral blood mononuclear cells in vitro. Markers of IFN production were increased in myositis muscle.
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35
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Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
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Novel conformation of histidyl-transfer RNA synthetase in the lung: The target tissue in Jo-1 autoantibody-associated myositis
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Novel conformation of histidyl-tRNA synthetase generated by granzyme-B induced cleavage is enriched in the lung providing further emphasis on autoantigen expression in initiating micro-environments shaping disease expression
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Levine SM, Raben N, Xie D, et al. Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis. Arthritis Rheum 2007; 56:2729-2739. Novel conformation of histidyl-tRNA synthetase generated by granzyme-B induced cleavage is enriched in the lung providing further emphasis on autoantigen expression in initiating micro-environments shaping disease expression.
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Arthritis Rheum
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Levine, S.M.1
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Mi2, an autoantigen for dermatomyositis, is an ATP-dependant nucleosome remodelling factor
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Wang HB, Zhang Y. Mi2, an autoantigen for dermatomyositis, is an ATP-dependant nucleosome remodelling factor. Nucleic Acid Res 2001; 29:2517-2521.
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34248548843
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The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny
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Using a conditional gene targeting mouse model, a critical role of Mi-2 was elucidated showing that this nuclear protein is required for development of the basal epidermis
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Kashiwagi M, Morgan BA, Georgopoulos K. The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Development 2007; 134:1571-1582. Using a conditional gene targeting mouse model, a critical role of Mi-2 was elucidated showing that this nuclear protein is required for development of the basal epidermis.
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The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains
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Kimura Y, Sakai F, Nakano O, et al. The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains. J Biol Chem 2002; 277:20611-20617.
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Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene
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45549097432
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Mechanisms of disease: Autoantigens as clues to the pathogenesis of myositis
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This review highlights how autoantigens are clues to the pathogenesis of myositis and CAM
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Suber TL, Casciola-Rosen L, Rosen A. Mechanisms of disease: autoantigens as clues to the pathogenesis of myositis. Nat Clin Pract Rheumatol 2008; 4:201-209. This review highlights how autoantigens are clues to the pathogenesis of myositis and CAM.
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Suber, T.L.1
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