Semi-synthesis and biological activity of γ-lactones analogs of camptothecin

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6441-6443

  Li, Mingzong ^a   Tang, Weidong ^b   Zeng, Fuxing ^a   Lou, Liguang ^b   You, Tianpa ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antitumor activity; Camptothecin; Camptothecin derivatives; Semi synthesis; Topoisomerase I

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; GAMMA LACTONE DERIVATIVE; SULFORHODAMINE B; TOPOTECAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECA; CAMPTOTHECIN; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LACTONES; MODELS, CHEMICAL; MOLECULAR STRUCTURE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56249121861     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.074     Document Type: Article

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