-
1
-
-
0018903891
-
Bulk flow of brain interstitial fluid under normal and hyperosmolar conditions
-
Rosenberg GA, Kyner WT, Estrada E. Bulk flow of brain interstitial fluid under normal and hyperosmolar conditions. Am J Physiol 1980;238:F42-9.
-
(1980)
Am J Physiol
, vol.238
-
-
Rosenberg, G.A.1
Kyner, W.T.2
Estrada, E.3
-
2
-
-
0017351916
-
Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema
-
Reulen HJ, Graham R, Spatz M, Klatzo I. Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema. J Neurosurg 1977;46:24-35.
-
(1977)
J Neurosurg
, vol.46
, pp. 24-35
-
-
Reulen, H.J.1
Graham, R.2
Spatz, M.3
Klatzo, I.4
-
3
-
-
0026700607
-
Clearance of brain edema and macromolecules through the cortical extracellular space
-
Ohata K, Marmarou A. Clearance of brain edema and macromolecules through the cortical extracellular space. J Neurosurg 1992;77:387-96.
-
(1992)
J Neurosurg
, vol.77
, pp. 387-396
-
-
Ohata, K.1
Marmarou, A.2
-
4
-
-
0029001712
-
Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion
-
Lieberman DM, Laske DW, Morrison PF, Bankiewicz KS, Oldfield EH. Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion. J Neurosurg 1995;82:1021-9.
-
(1995)
J Neurosurg
, vol.82
, pp. 1021-1029
-
-
Lieberman, D.M.1
Laske, D.W.2
Morrison, P.F.3
Bankiewicz, K.S.4
Oldfield, E.H.5
-
5
-
-
23444437213
-
Convection-enhanced delivery of macromolecules in the brain
-
Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH. Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci U S A 1994;91:2076-80.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 2076-2080
-
-
Bobo, R.H.1
Laske, D.W.2
Akbasak, A.3
Morrison, P.F.4
Dedrick, R.L.5
Oldfield, E.H.6
-
6
-
-
0028144703
-
High-flow microinfusion: Tissue penetration and pharmacodynamics
-
Morrison PF, Laske DW, Bobo H, Oldfield EH, Dedrick RL. High-flow microinfusion: tissue penetration and pharmacodynamics. Am J Physiol 1994;266:R292-305.
-
(1994)
Am J Physiol
, vol.266
-
-
Morrison, P.F.1
Laske, D.W.2
Bobo, H.3
Oldfield, E.H.4
Dedrick, R.L.5
-
7
-
-
1442282498
-
Convection-enhanced delivery of paclitaxel for the treatment of recurrent malignant glioma: A phase I/II clinical study
-
Lidar Z, Mardor Y, Jonas T, et al. Convection-enhanced delivery of paclitaxel for the treatment of recurrent malignant glioma: a phase I/II clinical study. J Neurosurg 2004;100:472-9.
-
(2004)
J Neurosurg
, vol.100
, pp. 472-479
-
-
Lidar, Z.1
Mardor, Y.2
Jonas, T.3
-
8
-
-
0344876636
-
Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas
-
Weaver M, Laske DW. Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas. J Neurooncol 2003;65:3-13.
-
(2003)
J Neurooncol
, vol.65
, pp. 3-13
-
-
Weaver, M.1
Laske, D.W.2
-
9
-
-
10744219583
-
Progress report of a phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-α and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors
-
Sampson JH, Akabani G, Archer GE, et al. Progress report of a phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-α and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors. J Neurooncol 2003;65:27-35.
-
(2003)
J Neurooncol
, vol.65
, pp. 27-35
-
-
Sampson, J.H.1
Akabani, G.2
Archer, G.E.3
-
10
-
-
0344444830
-
Interleukin-4-Pseudomonas exotoxin chimeric fusion protein for malignant glioma therapy
-
Kawakami M, Kawakami K, Puri RK. Interleukin-4-Pseudomonas exotoxin chimeric fusion protein for malignant glioma therapy. J Neurooncol 2003;65:15-25.
-
(2003)
J Neurooncol
, vol.65
, pp. 15-25
-
-
Kawakami, M.1
Kawakami, K.2
Puri, R.K.3
-
11
-
-
0344876629
-
Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: From bench to bedside
-
Husain SR, Puri RK. Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedside. J Neurooncol 2003;65:37-48.
-
(2003)
J Neurooncol
, vol.65
, pp. 37-48
-
-
Husain, S.R.1
Puri, R.K.2
-
12
-
-
23044462079
-
Convection-enhanced drug delivery: Increased efficacy and magnetic resonance image monitoring
-
Mardor Y, Rahav O, Zauberman Y, et al. Convection-enhanced drug delivery: increased efficacy and magnetic resonance image monitoring. Cancer Res 2005;65:6858-63.
-
(2005)
Cancer Res
, vol.65
, pp. 6858-6863
-
-
Mardor, Y.1
Rahav, O.2
Zauberman, Y.3
-
13
-
-
0027732538
-
Proteins regulating Ras and its relatives
-
Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature 1993;366:643-54.
-
(1993)
Nature
, vol.366
, pp. 643-654
-
-
Boguski, M.S.1
McCormick, F.2
-
14
-
-
0035844149
-
Differential activation of the Rac pathway by Ha-Ras and K-Ras
-
Walsh AB, Bar-Sagi D. Differential activation of the Rac pathway by Ha-Ras and K-Ras. J Biol Chem 2001;276:15 609-15.
-
(2001)
J Biol Chem
, vol.276
, Issue.15
, pp. 609-615
-
-
Walsh, A.B.1
Bar-Sagi, D.2
-
15
-
-
0030052368
-
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
-
Joneson T, White MA, Wigler MH, Bar Sagi D. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 1996;271:810-2.
-
(1996)
Science
, vol.271
, pp. 810-812
-
-
Joneson, T.1
White, M.A.2
Wigler, M.H.3
Bar Sagi, D.4
-
16
-
-
33846205171
-
A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration
-
Goldberg L, Kloog Y. A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration. Cancer Res 2006;66:11709-17.
-
(2006)
Cancer Res
, vol.66
, pp. 11709-11717
-
-
Goldberg, L.1
Kloog, Y.2
-
17
-
-
0031936353
-
Ras signalling and apoptosis
-
Downward J. Ras signalling and apoptosis. Curr Opin Genet Dev 1998;8:49-54.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 49-54
-
-
Downward, J.1
-
18
-
-
0027212082
-
Signal transduction. How receptors turn Ras on
-
McCormick F. Signal transduction. How receptors turn Ras on. Nature 1993;363:15-6.
-
(1993)
Nature
, vol.363
, pp. 15-16
-
-
McCormick, F.1
-
19
-
-
0032477606
-
-
Haklai R, Gana-Weisz M, Elad G, et al. Dislodgment and accelerated degradation of Ras. Biochemistry 1998;37:1306-14.
-
Haklai R, Gana-Weisz M, Elad G, et al. Dislodgment and accelerated degradation of Ras. Biochemistry 1998;37:1306-14.
-
-
-
-
20
-
-
13444283313
-
Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1α, causing glycolysis shutdown and cell death
-
Blum R, Jacob-Hirsch J, Amariglio N, Rechavi G, Kloog Y. Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1α, causing glycolysis shutdown and cell death. Cancer Res 2005;65:999-1006.
-
(2005)
Cancer Res
, vol.65
, pp. 999-1006
-
-
Blum, R.1
Jacob-Hirsch, J.2
Amariglio, N.3
Rechavi, G.4
Kloog, Y.5
-
21
-
-
33745472798
-
E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition
-
Blum R, Nakdimon I, Goldberg L, et al. E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition. Int J Cancer 2006;119:527-38.
-
(2006)
Int J Cancer
, vol.119
, pp. 527-538
-
-
Blum, R.1
Nakdimon, I.2
Goldberg, L.3
-
22
-
-
0028959539
-
Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth
-
Marciano D, Ben-Baruch G, Marom M, Egozi Y, Haklai R, Kloog Y. Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. J Med Chem 1995;38:126 7-72.
-
(1995)
J Med Chem
, vol.38
, Issue.126
, pp. 7-72
-
-
Marciano, D.1
Ben-Baruch, G.2
Marom, M.3
Egozi, Y.4
Haklai, R.5
Kloog, Y.6
-
23
-
-
0031055415
-
-
de Rooij J, Bos JL. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 1997;14:623-5.
-
de Rooij J, Bos JL. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 1997;14:623-5.
-
-
-
-
24
-
-
34250726637
-
Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid)
-
Zundelevich A, Elad-Sfadia G, Haklai R, Kloog Y. Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid). Mol Cancer Ther 2007;6:1765-73.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1765-1773
-
-
Zundelevich, A.1
Elad-Sfadia, G.2
Haklai, R.3
Kloog, Y.4
-
25
-
-
20444438759
-
Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest
-
Yaari S, Jacob-Hirsch J, Amariglio N, Haklai R, Rechavi G, Kloog Y. Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest. Clin Cancer Res 2005;11:4321-30.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4321-4330
-
-
Yaari, S.1
Jacob-Hirsch, J.2
Amariglio, N.3
Haklai, R.4
Rechavi, G.5
Kloog, Y.6
-
26
-
-
33749354937
-
The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1
-
Barkan B, Starinsky S, Friedman E, Stein R, Kloog Y. The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1. Clin Cancer Res 2006;12:5533-42.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5533-5542
-
-
Barkan, B.1
Starinsky, S.2
Friedman, E.3
Stein, R.4
Kloog, Y.5
-
27
-
-
0036184738
-
The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance
-
Gana-Weisz M, Halaschek-Wiener J, Jansen B, Elad G, Haklai R, Kloog Y. The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance. Clin Cancer Res 2002;8:555-65.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 555-565
-
-
Gana-Weisz, M.1
Halaschek-Wiener, J.2
Jansen, B.3
Elad, G.4
Haklai, R.5
Kloog, Y.6
-
28
-
-
0642336108
-
Glioblastoma multiforme: Introduction
-
Markert J. Glioblastoma multiforme: introduction. Cancer J 2003;9:148.
-
(2003)
Cancer J
, vol.9
, pp. 148
-
-
Markert, J.1
-
29
-
-
0031465906
-
Proliferation of human malignant astrocytomas is dependent on Ras activation
-
Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene 1997;15:2755-65.
-
(1997)
Oncogene
, vol.15
, pp. 2755-2765
-
-
Guha, A.1
Feldkamp, M.M.2
Lau, N.3
Boss, G.4
Pawson, A.5
-
30
-
-
33644815892
-
Tailoring Ras-pathway-inhibitor combinations for cancer therapy
-
Blum R, Kloog Y. Tailoring Ras-pathway-inhibitor combinations for cancer therapy. Drug Resist Updat 2005;8:369-80.
-
(2005)
Drug Resist Updat
, vol.8
, pp. 369-380
-
-
Blum, R.1
Kloog, Y.2
-
31
-
-
0025989627
-
Hepatocyte adhesion to carbohydrate-derivatized surfaces. II. Regulation of cytoskeletal organization and cell morphology
-
Weisz OA, Schnaar RL. Hepatocyte adhesion to carbohydrate-derivatized surfaces. II. Regulation of cytoskeletal organization and cell morphology. J Cell Biol 1991;115:495-504.
-
(1991)
J Cell Biol
, vol.115
, pp. 495-504
-
-
Weisz, O.A.1
Schnaar, R.L.2
-
32
-
-
0033559885
-
Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist
-
Egozi Y, Weisz B, Gana-Weisz M, Ben-Baruch G, Kloog Y. Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist. Int J Cancer 1999;80:911-8.
-
(1999)
Int J Cancer
, vol.80
, pp. 911-918
-
-
Egozi, Y.1
Weisz, B.2
Gana-Weisz, M.3
Ben-Baruch, G.4
Kloog, Y.5
-
34
-
-
0013227128
-
A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice
-
Weisz B, Giehl K, Gana-Weisz M, et al. A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice. Oncogene 1999;18:2579-88.
-
(1999)
Oncogene
, vol.18
, pp. 2579-2588
-
-
Weisz, B.1
Giehl, K.2
Gana-Weisz, M.3
-
35
-
-
0033400494
-
Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice
-
Jansen B, Heere-Ress E, Schlagbauer-Wadl H, et al. Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice. J Mol Med 1999;77:792-7.
-
(1999)
J Mol Med
, vol.77
, pp. 792-797
-
-
Jansen, B.1
Heere-Ress, E.2
Schlagbauer-Wadl, H.3
-
36
-
-
34848874825
-
Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice
-
Haklai R, Elad-Sfadia G, Egozi Y, Kloog Y. Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. Cancer Chemother Pharmacol 2008;61:89-96.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 89-96
-
-
Haklai, R.1
Elad-Sfadia, G.2
Egozi, Y.3
Kloog, Y.4
-
37
-
-
0038796537
-
The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model
-
Shohami E, Yatsiv I, Alexandrovich A, et al. The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. J Cereb Blood Flow Metab 2003;23:728-38.
-
(2003)
J Cereb Blood Flow Metab
, vol.23
, pp. 728-738
-
-
Shohami, E.1
Yatsiv, I.2
Alexandrovich, A.3
|