Resveratrol's effect on acute phases of focal cerebral ischemic injury in mice

Chinese Pharmacological Bulletin

Volumn 24, Issue 8, 2008, Pages 1032-1035

  Dong, Wen Pen ^a   Zhang, Xiang ^a   Gao, Da Kuan ^a   Zhen, Hai Ning ^a   Li, Bin ^a   Cao, Lei ^a   Lin, Hong ^a   Huo, Jun Li ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Blood brain barrier; Ischemia reperfusion injury; Peroxisome proliferator activated receptor; Resveratrol

Indexed keywords

EVANS BLUE; FENOFIBRATE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RESVERATROL; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; BRAIN PROTECTION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; GENE EXPRESSION; MALE; MOUSE; NONHUMAN; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING;

EID: 56249094879     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Baur J A, Sinclair D A. Therapeutic potential of resveratrol:the in vivo evidence[J]. Nat Rev Drug Discov,2006,5(6):493-506.
2. Yang Y B, Luo J H, Xu J P, et al. The inhibitive effects of resveratrol on adhesion of neutrophils to HUVECs induced by fMLP[J]. Chin Pharmacol Bull,2007,23(12):1588-93.
3. Inoue H, Jiang X F, Katayama T, et al. Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice[J]. Neurosci Lett,2003,352(3): 203-6.
4. Gao D, Zhang X, Jiang X, et al. Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia-reperfusion in mice [J]. Life Sci,2006,78(2):2564-70.
5. Vanden Berghe W, Vermeulen L, Delerive P, et al. A paradigm for gene regulation:inflammation, NF-kappaB and PPAR[J]. Adv Exp Med Biol,2003,544:181-96.
6. Kielian T, Drew P D. Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation [J]. J Neurosci Res,2003,71(3):315-25.
7. Zhang H L, Gu Z L, Qin Z H. Peroxisome prolifreator-activated receptors and neurodegenerative diseases[J]. Chin Pharmacol Bull, 2006,22(4): 397-402.
8. Moreno S, Farioli-Vecchioli S, Ceru M P. Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS[J]. Neuroscience,2004,123(1):131-45.
9. Li Y, Lu Z Y, Ogle M, et al. Erythropoietin prevents blood brain barrier damage induced by focal cerebral ischemia in mice [J]. Neurochem Res,2007,32(12):2132-41.
10. Huang S S, Tsai M C, Chih C L, et al. Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia [J]. Life Sci,2001,69(9):1057-65.
11. Sinha K, Chaudhary G, Gupta Y K. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats[J]. Life Sci,2002,71(6):655-65.
12. Wang M J, Huang H M, Hsieh S J, et al. Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/ hypoglycemia followed by reoxygenation[J]. J Neuroimmunol,2001, 112(1-2):28-34.
13. Deplanque D, Gele P, Petrault O, et al. Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment[J]. J Neurosci, 2003,23(15):6264-71.
14. Collino M, Aragno M, Mastrocola R, et al. Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643 [J]. Free Radic Biol Med,2006,41(4):579-89.
15. Ouk T, Petrault O, Gautier S, et al. PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases [J]. J Cereb Blood Flow Metab,2005,25(Suppl 1):S56.