Medullary autonomic pathology in carotid sinus hypersensitivity

Neuropathology and Applied Neurobiology

Volumn 34, Issue 4, 2008, Pages 403-411

  Miller, V M ^a,b,d   Kenny, R A ^c   Slade, J Y ^a   Oakley, A E ^a   Kalaria, R N ^a,b  

^a Sir James Spence Institute   (United Kingdom)

^b NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d WADSWORTH CENTER   (United States)

Author keywords

Baroreflex; Braak staging; Carotid sinus hypersensitivity; Medullary autonomic nuclei; Pathology

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; TAU PROTEIN; TYROSINE 3 MONOOXYGENASE;

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; AUTONOMIC NEUROPATHY; CAROTID SINUS HYPERSENSITIVITY; CAROTID SINUS PRESSORECEPTOR; CATECHOLAMINE NERVE CELL; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIFFUSE LEWY BODY DISEASE; DIGITAL IMAGING; DIZZINESS; FALLING; FEMALE; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MOTONEURON NUCLEUS; NEUROPATHOLOGY; NEUROTRANSMISSION; PARKINSON DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; VAGUS NERVE; CADAVER; CAROTID SINUS; HYPERSENSITIVITY; LEWY BODY; MEDULLA OBLONGATA; METABOLISM; NERVE CELL; PATHOLOGY; REFERENCE VALUE;

AGED; AGED, 80 AND OVER; AMYLOID BETA-PROTEIN; CADAVER; CAROTID SINUS; FEMALE; HUMANS; HYPERSENSITIVITY; LEWY BODIES; MALE; MEDULLA OBLONGATA; MICROGLIA; NEURONS; REFERENCE VALUES; TAU PROTEINS;

EID: 56149120473     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2007.00903.x     Document Type: Article

References (21)

1. Freitas J, Santos R, Azevedo E, Carvalho M. Carotid sinus syndrome in an unselected population of eight hundred consecutive patients with syncope. Prevalence and clinical profile. Rev Port Cardiol 2004; 23: 835-840 (Pubitemid 39044742)
2. Machado BH, Mauad H, Chianca Junior DA, Haibara AS, Colombari E. Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii, Braz J Med Biol Res 1997;30:533-613 (Pubitemid 127518296)
3. McAllen RM, Spyer KM. The location of cardiac vagal preganglionic motoneurones in the medulla of the cat. J Physiol 1976; 258: 187-204
4. Aviado DM, Guevara Aviado D, The Bezold-Jarisch reflex, A historical perspective of cardiopulmonary reflexes, Ann NY Acad Sci 2001; 940: 48-58
5. Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K. Stages in the development of Parkinson's diseaserelated pathology. Cell Tissue Res 2004; 318: 121-134 (Pubitemid 39362633)
6. Rub U, Del Tredici K, Schultz C, Thai DR, Braak E, Braak H, The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathology, Acta Neuropathol (Berl) 2001; 101: 555-564 (Pubitemid 32684753)
7. Parvizi J, Van Hoesen GW, Damasio A. The selective vulnerability of brainstem nuclei to Alzheimer's disease. Ann Neurol 2001; 49: 53-66 (Pubitemid 32163006)
8. Kenny RA, Kalaria R, Ballard C. Neurocardiovascular instability in cognitive impairment and dementia. Ann N Y Acad Sci 2002; 977: 183-195 (Pubitemid 35418154)
9. Wood B, Walker R, Parkinson's disease: characteristics of fallers and non-fallers. Age Ageing 2001; 30: 423-424
10. Brignole M, Alboni P, Benditt D, Bergfeldt L, Blanc JJ. Bloch Thomsen PE, Fitzpatrick A, Hohnloser S, Kapoor W, Kenny RA, Theodorakis G, Kulakowski P, Moya A, Raviele A, Sutton R, Wieling W, Janousek J, van Dijk G, Task Force on Syncope, European Society of Cardiology Task force on syncope, European Society of Cardiology, Part 2. Diagnostic tests and treatment: summary of recommendations. Europace 2001 Oct; 3(4): 261-268
11. Thai DR, Rub U, Orantes M, Braak H. Phases of A betadeposition in the human brain and its relevance for the development of AD. Neurology 2002; 58: 1791-1800 (Pubitemid 34663580)
12. Braak H, Braak E. Diagnostic criteria for neuropathologic assessment of Alzheimer's disease. Neurobiol Aging 1997; 18(4 Suppl.):S85-8 (Pubitemid 27454703)
13. Miller VM, Kalaria RN, Hall R, Oakley AE, Kenny RA. Medullary microvessel degeneration in multiple system atrophy. Neurobiol Dis 2007; 26: 615-622 (Pubitemid 46756329)
14. Parry SW, Steen N, Baptist M, Fiaschi KA, Parry O, Kenny RA, Cerebral autoregulation is impaired in cardioinhibitory carotid sinus syndrome. Heart 2006; 92: 792-797 (Pubitemid 43799213)
15. Mcintosh SJ, Lawson J, Kenny RA, Clinical characteristics of vasodepressor, cardioinhibitory, and mixed carotid sinus syndrome in the elderly. Am J Med 1993; 95: 203-208 (Pubitemid 23242714)
16. Armstrong RA, Cairns NJ, Lantos PL. Multiple system atrophy (MSA): topographic distribution of the alphasynuclein-associated pathological changes. Parkinsonism Relat Disord 2006; 12: 356-362
17. Benarroch EE, Schmeichel AM, Parisi JE, Involvement of the ventrolateral medulla in parkinsonism with autonomic failure. Neurology 2000; 54: 963-968
18. Benarroch EE, Schmeichel AM, Low PA, Boeve BF, Sandroni P, Parisi JE. Involvement of medullary regions controlling sympathetic output in Lewy body disease, Brain 2005; 128:338-344 (Pubitemid 40222602)
19. Benarroch EE, Schmeichel AM, Sandroni P, Low PA, Parisi JE. Involvement of vagal autonomic nuclei in multiple system atrophy and Lewy body disease. Neurology 2006;66:378-383 (Pubitemid 43739940)
20. Gai WP, Geffen LB, Denoroy L, Blessing WW. Loss of C1 and C3 epinephrine-synthesizing neurons in the medulla oblongata in Parkinson's disease. Ann Neurol 1993; 33: 357-367 (Pubitemid 23103967)
21. Kerr SR, Pearce MS, Brayne C, Davis RJ, Kenny RA. Carotid sinus hypersensitivity in asymptomatic older persons: implications for diagnosis of syncope and falls. Arch Intern Med 2006; 166: 515-520