The binding of antibiotics to ERp57/GRP58

Journal of Antibiotics

Volumn 61, Issue 6, 2008, Pages 400-402

  Gaucci, Elisa ^a   Chichiarelli, Silvia ^a   Grillo, Caterina ^a   Del Vecchio, Emiliana ^a   Eufemi, Margherita ^a   Turano, Carlo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Aminoglycoside antibiotics; ERp57 GRP58; Erythromycin; Vancomycin

Indexed keywords

AMPICILLIN; ERYTHROMYCIN; LIGAND; NEOMYCIN; PROTEIN DISULFIDE ISOMERASE; PROTEIN DISULFIDE ISOMERASE ERP57; RIBOSTAMYCIN; STREPTOMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; DNA; DNA BINDING PROTEIN; ENZYME INHIBITOR; PDIA3 PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN DNA BINDING; BINDING SITE; DRUG ANTAGONISM; HUMAN; METABOLISM; PROTEIN BINDING;

ANTI-BACTERIAL AGENTS; BINDING SITES; DNA; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HUMANS; LIGANDS; PROTEIN BINDING; PROTEIN DISULFIDE-ISOMERASE; RECOMBINANT PROTEINS;

EID: 56149117889     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.56     Document Type: Article

References (11)

1. Turano C, Coppari S, Altieri F, Ferraro A. Proteins of the PDI family: unpredicted non-ER locations and functions. J Cell Physiol 193: 154-163 (2002)
2. Ellerman DA, Myles DG, Primakoff P. A role for sperm surface protein disulfide isomerase activity in gamete fusion: evidence for the participation of ERp57. Dev Cell 10: 831-837 (2006)
3. Nemere I, Safford SE, Rohe B, DeSouza MM, Farach-Carson MC. Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein. J Steroid Biochem Mol Biol 89-90: 281-285 (2004)
4. Ndubuisi MI, Guo GG, Fried VA, Etlinger JD, Sehgal PB. Cellular physiology of STAT3: Where's the cytoplasmic monomer? J Biol Chem 274: 25499-25509 (1999)
5. Eufemi M, Coppari S, Altieri F, Grillo C, Ferraro A, Turano C. ERp57 is present in STAT3-DNA complexes. Biochem Biophys Res Commun 323: 1306-1312 (2004)
6. Chichiarelli S, Ferraro A, Altieri F, Eufemi M, Coppari S, Grillo C, Arcangeli V, Turano C. The stress protein ERp57/GRP58 binds specific DNA sequences in HeLa cells. J Cell Physiol 210: 343-351 (2007)
7. Urade R, Oda T, Ito H, Moriyama T, Utsumi S, Kito M. Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease. J Biochem (Tokyo) 122: 834-842 (1997)
8. Morjana NA, Gilbert HF. Effect of protein and peptide inhibitors on the activity of protein disulfide isomerase. Biochemistry 30: 4985-4990 (1991)
9. Horibe T, Nagai H, Matsui H, Hagiwara Y, Kikuchi M. Aminoglycoside antibiotics bind to protein disulfide isomerase and inhibit its chaperone activity. J Antibiot 55: 528-530 (2002)
10. Heuck AP, Wolosiuk RA. Di-fluoresceinthiocarbamyl-insulin: a fluorescent substrate for the assay of protein disulfide oxidoreductase activity. Anal Biochem 248: 94-101 (1997)
11. Ferraro A, Altieri F, Coppari S, Eufemi M, Chichiarelli S, Turano C. Binding of the protein disulfide isomerase isoform ERp60 to the nuclear matrix-associated regions of DNA. J Cell Biochem 72: 528-539 (1999)