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Volumn 7, Issue 5, 2008, Pages 660-662

The feasibility of uPA/uPAR-targeting strategies in cancer treatment

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; INTEGRIN; PLASMINOGEN; UROKINASE; UROKINASE RECEPTOR; VITRONECTIN; CELL SURFACE RECEPTOR; UROKINASE TYPE PLASMINOGEN ACTIVATOR RECEPTORS; UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTORS;

EID: 56149115949     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.5.6076     Document Type: Note
Times cited : (4)

References (33)
  • 1
    • 0029067419 scopus 로고
    • The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility
    • Bugge TH, Suh TT, Flick MJ, et al. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility. J Biol Chem 1995; 270:16886-94.
    • (1995) J Biol Chem , vol.270 , pp. 16886-16894
    • Bugge, T.H.1    Suh, T.T.2    Flick, M.J.3
  • 3
    • 0036906177 scopus 로고    scopus 로고
    • uPAR: A versatile signalling orchestrator
    • Blasi F, Carmeliet P. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 2002; 3:932-43.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 932-943
    • Blasi, F.1    Carmeliet, P.2
  • 4
    • 0041737535 scopus 로고    scopus 로고
    • Molecular mechanisms of glioma invasiveness: The role of proteases
    • Rao JS. Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer 2003; 3:489-501.
    • (2003) Nat Rev Cancer , vol.3 , pp. 489-501
    • Rao, J.S.1
  • 5
    • 35048812952 scopus 로고    scopus 로고
    • Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity
    • Shi Z, Stack MS. Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity. Biochem J 2007; 407:153-9.
    • (2007) Biochem J , vol.407 , pp. 153-159
    • Shi, Z.1    Stack, M.S.2
  • 6
    • 0023101058 scopus 로고
    • Activation of the fibrinolytic system
    • Robison AK CD. Activation of the fibrinolytic system. Cardiol Clin 1987; 5:13-9.
    • (1987) Cardiol Clin , vol.5 , pp. 13-19
    • Robison, A.C.1
  • 7
    • 0033858791 scopus 로고    scopus 로고
    • Fibrinolysis: An unfinished agenda
    • Gurewich V. Fibrinolysis: an unfinished agenda. Blood Coagul Fibrinolysis 2000; 11:401-8.
    • (2000) Blood Coagul Fibrinolysis , vol.11 , pp. 401-408
    • Gurewich, V.1
  • 8
    • 0029056684 scopus 로고
    • Plasminogen activators and plasminogen activator inhibitors: Biochemical aspects
    • Rijken D. Plasminogen activators and plasminogen activator inhibitors: biochemical aspects. Baillieres Clin Haematol 1995; 8:291-312.
    • (1995) Baillieres Clin Haematol , vol.8 , pp. 291-312
    • Rijken, D.1
  • 9
    • 0016758852 scopus 로고
    • The activation mechanism of human plasminogen
    • Rickli E. The activation mechanism of human plasminogen. Thromb Diath Haemorrh 1975; 34:386-95.
    • (1975) Thromb Diath Haemorrh , vol.34 , pp. 386-395
    • Rickli, E.1
  • 10
    • 0034996039 scopus 로고    scopus 로고
    • The role of the plasminogen activation system in angiogenesis and metastasis
    • Rabbani SA MA. The role of the plasminogen activation system in angiogenesis and metastasis. Surg Oncol Clin N Am 2001; 10:393-415.
    • (2001) Surg Oncol Clin N Am , vol.10 , pp. 393-415
    • Rabbani, S.M.1
  • 11
    • 0035721955 scopus 로고    scopus 로고
    • Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis
    • Pepper M. Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis. Arterioscler Thromb Vasc Biol 2001; 21:1104-17.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1104-1117
    • Pepper, M.1
  • 12
    • 0035298106 scopus 로고    scopus 로고
    • uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration
    • Legrand C PM, Tournier JM, de Bentzmann S, Huet E, Monteau M, Birembaut P. uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration. Exp Cell Res 2001; 264:326-36.
    • (2001) Exp Cell Res , vol.264 , pp. 326-336
    • Legrand, C.P.1    Tournier, J.M.2    de Bentzmann, S.3    Huet, E.4    Monteau, M.5    Birembaut, P.6
  • 14
    • 0032403005 scopus 로고    scopus 로고
    • Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene - phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator
    • Miyazawa KWY, Minoshima S, Shimizu N, Kitamura N. Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene - phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator. Eur J Biochem 1998; 258:355-61.
    • (1998) Eur J Biochem , vol.258 , pp. 355-361
    • Miyazawa, K.W.Y.1    Minoshima, S.2    Shimizu, N.3    Kitamura, N.4
  • 15
    • 21744439110 scopus 로고    scopus 로고
    • Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells
    • Ustach CV, Kim HR. Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. Mol Cell Biol 2005; 25:6279-88.
    • (2005) Mol Cell Biol , vol.25 , pp. 6279-6288
    • Ustach, C.V.1    Kim, H.R.2
  • 16
    • 0027380301 scopus 로고
    • Plasminogen-dependent activation of latent transforming growth factor beta (TGF beta) by growing cultures of osteoblast-like cells
    • Yee JA, Yan L, Dominguez JC, Allan EH, Martin TJ. Plasminogen-dependent activation of latent transforming growth factor beta (TGF beta) by growing cultures of osteoblast-like cells. J Cell Physiol 1993; 157:528-34.
    • (1993) J Cell Physiol , vol.157 , pp. 528-534
    • Yee, J.A.1    Yan, L.2    Dominguez, J.C.3    Allan, E.H.4    Martin, T.J.5
  • 17
    • 0030767291 scopus 로고    scopus 로고
    • Regulation of single chain urokinase binding, internalization, and degradation by a plasminogen activator inhibitor 1-derived peptide
    • Zhang L SD, Cines DB, Higazi AA. Regulation of single chain urokinase binding, internalization, and degradation by a plasminogen activator inhibitor 1-derived peptide. J Biol Chem 1997; 272:27053-7.
    • (1997) J Biol Chem , vol.272 , pp. 27053-27057
    • Zhang, L.S.1    Cines, D.B.2    Higazi, A.A.3
  • 18
    • 0030926412 scopus 로고    scopus 로고
    • Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes
    • Nykjaer A, Conese M, Christensen EI, et al. Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J 1997; 16:2610-20.
    • (1997) EMBO J , vol.16 , pp. 2610-2620
    • Nykjaer, A.1    Conese, M.2    Christensen, E.I.3
  • 19
    • 0001353920 scopus 로고
    • Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes
    • Nykjaer A, Petersen CM, Moller B, et al. Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J Biol Chem 1992; 267:14543-6.
    • (1992) J Biol Chem , vol.267 , pp. 14543-14546
    • Nykjaer, A.1    Petersen, C.M.2    Moller, B.3
  • 20
    • 0027370718 scopus 로고
    • Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase
    • Kounnas MZ, Henkin J, Argraves WS, Strickland DK. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase. J Biol Chem 1993; 268:21862-7.
    • (1993) J Biol Chem , vol.268 , pp. 21862-21867
    • Kounnas, M.Z.1    Henkin, J.2    Argraves, W.S.3    Strickland, D.K.4
  • 21
    • 33646271356 scopus 로고    scopus 로고
    • Maspin retards cell detachment via a novel interaction with the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system
    • Yin S, Lockett J, Meng Y, et al. Maspin retards cell detachment via a novel interaction with the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system. Cancer Res 2006; 66:4173-81.
    • (2006) Cancer Res , vol.66 , pp. 4173-4181
    • Yin, S.1    Lockett, J.2    Meng, Y.3
  • 22
    • 4344614173 scopus 로고    scopus 로고
    • The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion
    • Furlan F, Orlando S, Laudanna C, et al. The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion. J Cell Sci 2004; 117:2909-16.
    • (2004) J Cell Sci , vol.117 , pp. 2909-2916
    • Furlan, F.1    Orlando, S.2    Laudanna, C.3
  • 23
    • 0037294254 scopus 로고    scopus 로고
    • Synthetic urokinase inhibitors as potential antitumor drugs
    • Steinmetzer T. Synthetic urokinase inhibitors as potential antitumor drugs. IDrugs 2003; 6:138-46.
    • (2003) IDrugs , vol.6 , pp. 138-146
    • Steinmetzer, T.1
  • 24
    • 0035947634 scopus 로고    scopus 로고
    • Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin
    • Liu S, Bugge TH, Leppla SH. Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin. J Biol Chem 2001; 276:17976-84.
    • (2001) J Biol Chem , vol.276 , pp. 17976-17984
    • Liu, S.1    Bugge, T.H.2    Leppla, S.H.3
  • 25
    • 0034917045 scopus 로고    scopus 로고
    • cDNA transfection of amino-terminal fragment of urokinase efficiently inhibits cancer cell invasion and metastasis
    • Zhu F, Jia S, Xing G, Gao L, Zhang L, He F. cDNA transfection of amino-terminal fragment of urokinase efficiently inhibits cancer cell invasion and metastasis. DNA Cell Biol 2001; 20:297-305.
    • (2001) DNA Cell Biol , vol.20 , pp. 297-305
    • Zhu, F.1    Jia, S.2    Xing, G.3    Gao, L.4    Zhang, L.5    He, F.6
  • 26
    • 0030007538 scopus 로고    scopus 로고
    • In vitro anti-proliferative and anti-invasive role of aminoterminal fragment of urokinase-type plasminogen activator on 8701-BC breast cancer cells
    • Luparello C, Del Rosso M. In vitro anti-proliferative and anti-invasive role of aminoterminal fragment of urokinase-type plasminogen activator on 8701-BC breast cancer cells. Eur J Cancer 1996; 32:702-7.
    • (1996) Eur J Cancer , vol.32 , pp. 702-707
    • Luparello, C.1    Del Rosso, M.2
  • 28
    • 3042769439 scopus 로고    scopus 로고
    • Monoclonal antibodies against vascular endothelial growth factor and epidermal growth factor receptor in advanced colorectal cancers: Present and future directions
    • Starling N, Cunningham D. Monoclonal antibodies against vascular endothelial growth factor and epidermal growth factor receptor in advanced colorectal cancers: present and future directions. Curr Opin Oncol 2004; 16:385-90.
    • (2004) Curr Opin Oncol , vol.16 , pp. 385-390
    • Starling, N.1    Cunningham, D.2
  • 29
    • 1842665126 scopus 로고    scopus 로고
    • A bispecific immunotoxin (DTAT13) targeting human IL-13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model
    • Todhunter DA, Hall WA, Rustamzadeh E, Shu Y, Doumbia SO, Vallera DA. A bispecific immunotoxin (DTAT13) targeting human IL-13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model. Protein Eng Des Sel 2004; 17:157-64.
    • (2004) Protein Eng Des Sel , vol.17 , pp. 157-164
    • Todhunter, D.A.1    Hall, W.A.2    Rustamzadeh, E.3    Shu, Y.4    Doumbia, S.O.5    Vallera, D.A.6
  • 30
    • 0345307772 scopus 로고    scopus 로고
    • Targeting the overexpressed urokinase-type plasminogen activator receptor on glioblastoma multiforme
    • Rustamzadeh E, Li C, Doumbia S, Hall WA, Vallera DA. Targeting the overexpressed urokinase-type plasminogen activator receptor on glioblastoma multiforme. J Neurooncol 2003; 65:63-75.
    • (2003) J Neurooncol , vol.65 , pp. 63-75
    • Rustamzadeh, E.1    Li, C.2    Doumbia, S.3    Hall, W.A.4    Vallera, D.A.5
  • 31
    • 34547134691 scopus 로고    scopus 로고
    • Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice
    • Gondi CS, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS. Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice. Clin Cancer Res 2007; 13:4051-60.
    • (2007) Clin Cancer Res , vol.13 , pp. 4051-4060
    • Gondi, C.S.1    Lakka, S.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5    Rao, J.S.6
  • 32
    • 27744435789 scopus 로고    scopus 로고
    • RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo
    • Pulukuri SM, Gondi CS, Lakka SS, et al. RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo. J Biol Chem 2005; 280:36529-40.
    • (2005) J Biol Chem , vol.280 , pp. 36529-36540
    • Pulukuri, S.M.1    Gondi, C.S.2    Lakka, S.S.3
  • 33
    • 9144231998 scopus 로고    scopus 로고
    • RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
    • Gondi CS, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS. RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas. Oncogene 2004; 23:8486-96.
    • (2004) Oncogene , vol.23 , pp. 8486-8496
    • Gondi, C.S.1    Lakka, S.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5    Rao, J.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.