Fospropofol assay issues and impact on pharmacokinetic and pharmacodynamic evaluation

Anesthesiology

Volumn 109, Issue 5, 2008, Pages 937-

  Shah, Ajit ^a   Mistry, Bipin ^b   Gibiansky, Ekaterina ^b   Gibiansky, Leonid ^b  

^a GUILFORD PHARMACEUTICALS INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FOSPROPOFOL; PROPOFOL; VANADATE SODIUM; DRUG DERIVATIVE;

DRUG BLOOD LEVEL; DRUG METABOLISM; HEMOLYSIS; HUMAN; LETTER; PRIORITY JOURNAL; SEDATION; ANIMAL; BLOOD; DRUG SCREENING; METHODOLOGY;

ANIMALS; DRUG EVALUATION; HUMANS; PROPOFOL;

EID: 56149112724     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31818aa6e1     Document Type: Letter

References (6)

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2. FechnerJ, Ihmsen H, Hatterscheid D, Jeleazcov C, Schiessl C, VornovJJ, Schwilden H, SchüttlerJ: Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion. ANESTHESIOLOGY 2004; 101:626-39
3. Struys MMRF, Vanluchene ALG, Gibiansky E, Gibiansky L, VornovJ, Mortier EP, Van Bortel L: AQUAVAN® injection, a water-soluble prodrug of propofol, as a bolus injection: A phase I dose-escalation comparison with DIPRIVAN® (part 2): Pharmacodynamics and safety. ANESTHESIOLOGY 2005; 103:730-43
4. Gibiansky E, Struys MMRF, Gibiansky L, Vanluchene ALG, VornovJ, Mortier EP, Burak E, Van Bortel L: AQUAVAN® injection, a water-soluble prodrug of propofol, as bolus injection: A phase I dose-escalation comparison with DIPRIVAN® (part 1): Pharmacokinetics. ANESTHESIOLOGY 2005; 103:718-29
5. Schywalsky M, Ihmsen H, Tzabazis A, FechnerJ, Burak E, VornovJ, Schwilden H: Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats. Eur J Anaesthesiol 2003; 20:182-90
6. FechnerJ, Ihmsen H, Schiessl C, Jeleazcov C, VornovJJ, Schwilden H, SchuttlerJ: Sedation with GPI 15715, a water-soluble prodrug of propofol, using target-controlled infusion in volunteers. Anesth Analg 2005; 100: 701-6