The in-vivo activity of an antifungal antibiotic, benanomicin A, in comparison with amphotericin B and fluconazole

Journal of Antimicrobial Chemotherapy

Volumn 39, Issue 1, 1997, Pages 71-77

  Ohtsuka, Keiko ^a   Watanabe, Maki ^a   Orikasa, Yoshinori ^a   Inouye, Shigeharu ^a,d   Uchida, Katsuhisa ^b   Yamaguchi, Hideyo ^b   Kondo, Shinichi ^c   Takeuchi, Tomio ^c  

^a MEIJI SEIKA KAISHA LTD   (Japan)

^b TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^d CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; BENANOMICIN A; FLUCONAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; COMPARATIVE STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG COMPARISON; DRUG EFFICACY; MALE; MOUSE; MYCOSIS; NONHUMAN;

AMPHOTERICIN B; ANIMALS; ANTHRACYCLINES; ANTIBIOTICS, ANTIFUNGAL; ANTIBIOTICS, ANTINEOPLASTIC; ANTIFUNGAL AGENTS; ASPERGILLOSIS; CANDIDIASIS; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; FEMALE; FLUCONAZOLE; KIDNEY; MALE; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; MYCOSES;

EID: 0031059311     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/39.1.71     Document Type: Article

References (6)

1. Takeuchi, T., Hara, T., Naganawa, H., Okada, M., Hamada, M., Umezawa, H. et al. (1988). New antifungal antibiotics, benanomicins A and B from an actinomycete. Journal of Antibiotics 41, 807-11.
2. Watanabe, M., Hiratani, T., Uchida, K., Ohtsuka, K., Watabe, H., Inouye, S. et al. (1996). In-vitro activity of an antifungal antibiotic benanomicin A in comparison with amphotericin B. Journal of Antimicrobial Chemotherapy, 38, 1073-70.
3. Troke, P. F. K., Marriott, M. S., Richardson, J. & Tarbit, M. K. (1988). In vitro potency and in vivo activity of azoles. Annals of the New York Academy of Sciences 544, 284-93.
4. Fielding, R. M., Smith, P. C., Wang, L. H., Porter, J. & Quo, L. S. S. (1991). Comparative pharmacokinetics of amphotericin B after administration of a novel colloidal delivery system, ABCD, and a conventional formulation to rats. Antimicrobial Agents and Chemotherapy 35, 1208-13.
5. Humphrey, M. J., Jevons, S. & Tarbit, M. H. (1985). Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans. Antimicrobial Agents and Chemotherapy 28, 648-53.
6. Kondo, S., Ikeda, D., Hamada, M., Takeuchi, T., Tohyama, H., Watabe, H. et al. (1990). Structural requirements for antifungal activity of benanomicin A (ME1451). In Program and Abstracts of the 30th interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta, GA, 1990. Abstract 589, p. 184. American Society for Microbiology, Washington, DC.