Hypermucoviscosity as a virulence factor in experimental Klebsiella pneumoniae endophthalmitis

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 11, 2008, Pages 4931-4938

  Wiskur, Brandt J ^a   Hunt, Jonathan J ^b   Callegan, Michelle C ^a,b,c  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA RHYTHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BETA RHYTHM; CONTROLLED STUDY; DISEASE MODEL; ENDOPHTHALMITIS; EXPERIMENTAL INFECTION; GROWTH CURVE; HISTOPATHOLOGY; HYPERMUCOVISCOSITY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LUNG TUBERCULOSIS; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RETINA; VISCOSITY; ANIMAL; BACTERIAL EYE INFECTION; C57BL MOUSE; COMPARATIVE STUDY; ENTEROBACTER INFECTION; HOSPITALIZATION; MICROBIOLOGY; PATHOGENICITY; VIRULENCE;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOPHTHALMITIS; EYE INFECTIONS, BACTERIAL; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICE; MICE, INBRED C57BL; SEVERITY OF ILLNESS INDEX; VIRULENCE; VISCOSITY;

EID: 56149093434     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2276     Document Type: Article

References (43)

1. Jonas JB, Knorr HL, Budde WM. Prognostic factors in ocular injuries caused by intraocular or retrobulbar foreign bodies. Ophthalmology. 2000;107(5):823-828. (Pubitemid 30727987)
2. Meredith TA. Posttraumatic endophthalmitis. Arch Ophthalmol. 1999;117(4):520-521.
3. Danis RP. Endophthalmitis. Ophthalmol Clin North Am. 2002;15(2):243-248. (Pubitemid 35007030)
4. Thompson JT, Parver LM, Enger CL, Meiler WF, Ligget PE. Infectious endophthalmitis after penetrating injuries with retained intraocular foreign bodies. National Eye Trauma System. Ophthalmology. 1993;100(10):1468-1474.
5. West ES, Behrens A, McDonnell PJ, Tielsch JM, Schein OD. The incidence of endophthalmitis after cataract surgery among the U.S. Medicare population increased between 1994 and 2001. Ophthalmology. 2005;112(8):1388-1394.
6. Jackson TL, Eykyn SJ, Graham EM, Stanford MR. Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases. Surv Ophthalmol. 2003;48(4):403-423.
7. Okada AA, Johnson RP, Liles WC, D'Amico DJ, Baker AS. Endogenous bacterial endophthalmitis: report of a ten-year retrospective study. Ophthalmology. 1994;101(5):832-838.
8. Romero CF, Rai MK, Lowder CY, Adal KA. Endogenous endophthalmitis: case report and brief review. Am Fam Phys. 1999;60(2):510-514. (Pubitemid 29390271)
9. Christensen SR, Hansen AB, LaCour M, Fledelius HC. Bilateral endogenous bacterial endophthalmitis: a report of four cases. Acta Ophthalmol Scand. 2004;82(3):306-310. (Pubitemid 38714648)
10. Greenwald MJ, Wohl LG, Sell CH. Metastatic bacterial endophthalmitis: a contemporary reappraisal. Surv Ophthalmol. 1986;31(2):81-101.
11. Yu VL, Hansen DS, Ko WC, et al.; International Klebsiella Study Group. Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections. Emerg Infect Dis. 2007;13(7):986-993.
12. Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol. 1998;11(4):589-603. (Pubitemid 28497563)
13. Anderson DJ, Engemann JJ, Harrell LJ, Carmeli Y, Reller LB, Kaye KS. Predictors of mortality in patients with bloodstream infection due to ceftazidime-resistant Klebsiella pneumoniae. Antimicrob Agents Chemother. 2006;50(5):1715-1720.
14. Gomes CC, Vormittag E, Santos CR, Levin AS. Nosocomial infection with cephalosporin-resistant Klebsiella pneumoniae is not associated with increased mortality. Infect Control Hosp Epidemiol. 2006;27(9):907-912. (Pubitemid 44449247)
15. Tumbarello M, Sanguinetti M. Predictors of mortality in patient with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother. 2007;51(6):1987-1994. (Pubitemid 46903084)
16. Bratu S, Landman D, Haag R, Recco R, Eramo A. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch Intern Med. 2005;165(12):1430-1435. (Pubitemid 40973427)
17. Waites KB, Duffy LB, Dowzicky MJ. Antimicrobial susceptibility among pathogens collected from hospitalized patients in the United States and in vitro activity of tigecycline, a new glycylcycline antimicrobial. Antimicrob Agents Chemother. 2006;50(10):3479-3484.
18. Mazzariol A, Roelofsen E, Koncan R, Voss A, Cornaglia G. Detection of a new SHV-Type extended-spectrum β-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in the Netherlands. Antimicrob Agents Chemother. 2007;51(3):1082-1084. (Pubitemid 46355299)
19. Keynan Y, Rubinstein E. The changing face of Klebsiella pneumoniae infections in the community. Int J Antimicrob Agents. 2007;30(5):385-389. (Pubitemid 47498960)
20. Ko WC, Paterson DL, Sagnimeni AJ, et al. Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg Inf Dis. 2002;8(2):160-166.
21. Fang CT, Chuang YP, Chang SC, Wang JT. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med. 2005;199(5):697-705.
22. Fang FC, Sandler N, Libby SJ. Liver abscess caused by magA+ Klebsiella pneumoniae in North America. J Clin Micro. 2005;43(2):991-992. (Pubitemid 40256080)
23. Fung CP, Chang FY, Lee SC, et al. A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis? Gut. 2002;50(3):420-424.
24. Struve C, Bojer M, Nielsen EM, Hansen DS, Krogfelt KA. Investigation of putative virulence gene magA in a worldwide collection of 495 Klebsiella isolates: magA is restricted to the gene cluster of Klebsiella pneumoniae capsule serotype K1. J Med Microbiology. 2005;54(11):1111-1113. (Pubitemid 41566784)
25. Yeh KM, Karup A, Siu LK, et al. Capsular serotype K1 or K2, rather than magA and rmpA, is a major virulence determinant for Klebsiella pneumoniae liver abscess in Singapore and Taiwan. J Clin Microbiol. 2007;45(2):466-471.
26. Yu WL, Ko WC, Cheng KC, et al. Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Infect Dis. 2006;42(10):1351-1358.
27. Lin JC, Siu LK, Fung CP, et al. Impaired phagocytosis of capsular serotypes K1 or K2 Klebsiella pneumoniae in type 2 diabetes mellitus patients with poor-glycemic control. J Clin Endocrin Metab. 2006;91(8):3084-3087.
28. Lee HC, Chuang YC, Yu WL, et al. Clinical implications of hypermucoviscosity phenotype in Klebsiella pneumoniae isolates in patients with community-acquired bacteraemia. J Int Med. 2006;259:606-614.
29. Struve C, Krogfelt KA. Role of capsule in Klebsiella pneumoniae virulence: lack of correlation between in vitro and in vivo studies. FEMS Microb Lett. 2003;218:149-154. (Pubitemid 36173541)
30. Yeh KM, Chang FY, Fung CP, Lin JC, Siu LK. magA is not a specific virulence gene for Klebsiella pneumoniae strains causing liver abscess but is part of the capsular polysaccharide gene cluster of K. pneumoniae serotype K1. J Med Microbiol. 2006;55(6):803-804.
31. Callegan MC, Booth MC, Jett BD, Gilmore MS. Pathogenesis of Gram-positive bacterial endophthalmitis. Infect Immun. 1999;67(7):3348-3356.
32. Chen W, Kuo T. A simple and rapid method for the preparation of Gram-negative bacterial genomic DNA. Nucleic Acid Res. 1993;21(9):2260. (Pubitemid 23160759)
33. Brody JR, Calhoun ES, Gallmeier E, Creavalle TD, Kern SE. Ultrafast high-resolution agarose electrophoresis of DNA and RNA using low-molarity conductive media. Biotechniques. 2004;37(4):598,600,602. (Pubitemid 39391176)
34. Ramadan RT, Ramirez R, Novosad BD, Callegan MC. Acute inflammation and loss of retinal architecture and function during experimental Bacillus endophthalmitis. Curr Eye Res. 2006;31:1-11.
35. Sheehan DC, Hrapchak BB. Theory and Practice of Histotechnology. Columbus, OH: Batelle Press; 1987.
36. Yu WL, Ko WC, Cheng KC, Lee CC, Lai CC, Chuang YC. Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes. Diagn Microbiol Infect Dis. Published online May 15, 2008.
37. Englebert M, Gilmore MS. Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis. Invest Ophthalmol Vis Sci. 2005;46(7):2479-2486.
38. Booth MC, Atkuri RV, Nanda SK, Iandolo JJ, Gilmore MS. Accessory gene regulator controls Staphylococcus aureus virulence in endophthalmitis. Invest Ophthalmol Vis Sci. 1995;36(9):1828-1836.
39. Jett BD, Jensen HG, Atkuri RV, Gilmore MS. Evaluation of therapeutic measures for treating endophthalmitis caused by isogenic toxin-producing and toxin-nonproducing Enterococcus faecalis strains. Invest Ophthalmol Vis Sci. 1995(1):36:9-15.
40. Meyers-Elliot RH, Dethlefs BA. Experimental Klebsiella-induced endophthalmitis in the rabbit. Arch Ophthalmol. 1982;100:1959-1963.
41. Trishin AV, Zhdanovich MI, Savvateeva LV, et al. Protease activity of Klebsiella pneumoniae of different virulence (in Russian). Zh Mikrobiol Epidemiol Immunobiol. 2004;Jul-Aug(4):7-11.
42. Chavan M, Rafi H, Wertz J, Goldstone C, Riley. Phage associated bacteriocins reveal a novel mechanism for bacteriocin diversification in Klebsiella. J Mol Evol. 2005;60(4):546-556. (Pubitemid 40754795)
43. Sekowska A, Gospodarek E, Janickca G, Jachna-Sawicka K, Sawicki M. Hydrolytic and haemolytic activity of Klebsiella pneumoniae and Klebsiella oxytoca (in Polish). Med Dosw Mikrobiol. 2006;58(2):135-141.