Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat

Physiological Genomics

Volumn 35, Issue 1, 2008, Pages 30-35

  Schulz, Angela ^a   Hänsch, Jonna ^a   Kuhn, Kristina ^a   Schlesener, Maria ^a   Kossmehl, Peter ^a   Nyengaard, Jens R ^b   Wendt, Norbert ^a   Huber, Matthias ^a   Kreutz, Reinhold ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Albuminuria; Consomic rat; Gender; Genetics; Kidney

Indexed keywords

ALBUMINURIA; ANIMAL MODEL; ARTICLE; CHROMOSOME 8; CHROMOSOME SUBSTITUTION STRAIN; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE LOCUS; HYPERTENSION; KIDNEY DISEASE; MALE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT; SYSTOLIC BLOOD PRESSURE; WISTAR RAT; ANIMAL; CHROMOSOME; CONGENIC STRAIN; CYTOLOGY; GENETICS; SEXUAL DEVELOPMENT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALIA; RATTUS;

ALBUMINURIA; ANIMALS; ANIMALS, CONGENIC; CHROMOSOMES, MAMMALIAN; FEMALE; HYPERTENSION; MALE; NEPHRONS; RATS; RATS, INBRED SHR; SEX CHARACTERISTICS;

EID: 56149091288     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.90270.2008     Document Type: Article

References (31)

1. Barker DJ, Osmond C, Golding J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 298: 564-567, 1989.
2. Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1: 335-347, 1988.
3. Cowley AW Jr, Liang M, Roman RJ, Greene AS, Jacob HJ. Consomic rat model systems for physiological genomics. Acta Physiol Scand 181: 585-592, 2004.
4. Fassi A, Sangalli F, Maffi R, Colombi F, Mohamed EI, Brenner BM, Remuzzi G, Remuzzi A. Progressive glomerular injury in the MWF rat is predicted by inborn nephron deficit. J Am Soc Nephrol 9: 1399-1406, 1998.
5. Fogarty DG, Hanna LS, Wantman M, Warram JH, Krolewski AS, Rich SS. Segregation analysis of urinary albumin excretion in families with type 2 diabetes. Diabetes 49: 1057-1063, 2000.
6. Fox CS, Yang Q, Guo CY, Cupples LA, Wilson PW, Levy D, Meigs JB. Genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: the Framingham Heart Study. Kidney Int 67: 70-74, 2005.
7. Freedman BI, Beck SR, Rich SS, Heiss G, Lewis CE, Turner S, Province MA, Schwander KL, Arnett DK, Mellen BG. A genome-wide scan for urinary albumin excretion in hypertensive families. Hypertension 42: 291-296, 2003.
8. Freedman BI, Bowden DW, Rich SS, Xu J, Wagenknecht LE, Ziegler J, Hicks PJ, Langefeld CD. Genome-wide linkage scans for renal function and albuminuria in Type 2 diabetes mellitus: the Diabetes Heart Study. Diabet Med 25: 268-276, 2008.
9. Garrett MR, Dene H, Rapp JP. Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. J Am Soc Nephrol 14: 1175-1187, 2003.
10. Gundersen HJ. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R Thompson. J Microsc 143: 3-45, 1986.
11. Hershkovitz D, Burbea Z, Skorecki K, Brenner BM. Fetal programming of adult kidney disease: cellular and molecular mechanisms. Clin J Am Soc Nephrol 2: 334-342, 2007.
12. Hwang SJ, Yang Q, Meigs JB, Pearce EN, Fox CS. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. BMC Med Genet 8, Suppl 1: S10, 2007.
13. Iyengar SK, Abboud HE, Goddard KA, Saad MF, Adler SG, Arar NH, Bowden DW, Duggirala R, Elston RC, Hanson RL, Ipp E, Kao WH, Kimmel PL, Klag MJ, Knowler WC, Meoni LA, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Quade SR, Rich SS, Rotter JI, Scavini M, Schelling JR, Sedor JR, Sehgal AR, Shah VO, Smith MW, Taylor KD, Winkler CA, Zager PG, Freedman BI. Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes 56: 1577-1585, 2007.
14. Kreutz R, Kovacevic L, Schulz A, Rothermund L, Ketteler M, Paul M. Effect of high NaCl diet on spontaneous hypertension in a genetic rat model with reduced nephron number. J Hypertens 18: 777-782, 2000.
15. Krolewski AS, Poznik GD, Placha G, Canani L, Dunn J, Walker W, Smiles A, Krolewski B, Fogarty DG, Moczulski D, Araki S, Makita Y, Ng DP, Rogus J, Duggirala R, Rich SS, Warram JH. A genome-wide linkage scan for genes controlling variation in urinary albumin excretion in type II diabetes. Kidney Int 69: 129-136, 2006.
16. Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE. Recommendations for blood pressure measurement in humans and experimental animals: part 2: blood pressure measurement in experimental animals: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Arterioscler Thromb Vasc Biol 25: e22-e33, 2005.
17. Leon JM, Freedman BI, Miller MB, North KE, Hunt SC, Eckfeldt JH, Lewis CE, Kraja AT, Djousse L, Arnett DK. Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study. Nephrol Dial Transplant 22: 763-771, 2007.
18. Matsuyama M, Ogiu T, Kontani K, Yamada C, Kawai M, Hiai H, Nakamura T, Shimizu F, Toyokawa T, Kinoshita Y. Genetic regulation of the development of glomerular sclerotic lesions in the BUF/Mna rat. Nephron 54: 334-337, 1990.
19. Nuyt AM. Mechanisms underlying developmental programming of elevated blood pressure and vascular dysfunction: evidence from human studies and experimental animal models. Clin Sci (Lond) 114: 1-17, 2008.
20. Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J Am Soc Nephrol 16: 852-856, 2005.
21. Salzler HR, Griffiths R, Ruiz P, Chi L, Frey C, Marchuk DA, Rockman HA, Le TH. Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus. Kidney Int 72: 1226-1232, 2007.
22. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J. Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 18: 407-413, 2007.
23. Schulz A, Litfin A, Kossmehl P, Kreutz R. Genetic dissection of increased urinary albumin excretion in the Munich Wistar Fromter rat. J Am Soc Nephrol 13: 2706-2714, 2002.
24. Schulz A, Schlesener M, Weiss J, Hansch J, Wendt N, Kossmehl P, Grimm D, Vetter R, Kreutz R. Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL. Clin Sci (Lond) 114: 305-311, 2008.
25. Schulz A, Standke D, Kovacevic L, Mostler M, Kossmehl P, Stoll M, Kreutz R. A major gene locus links early onset albuminuria with renal interstitial fibrosis in the MWF rat with polygenetic albuminuria. J Am Soc Nephrol 14: 3081-3089, 2003.
26. Schulz A, Weiss J, Schlesener M, Hansch J, Wehland M, Wendt N, Kossmehl P, Sietmann A, Grimm D, Stoll M, Nyengaard JR, Kreutz R. Development of overt proteinuria in the Munich Wistar Fromter rat is suppressed by replacement of chromosome 6 in a consomic rat strain. J Am Soc Nephrol 18: 113-121, 2007.
27. Shiozawa M, Provoost AP, van Dokkum RP, Majewski RR, Jacob HJ. Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy. J Am Soc Nephrol 11: 2068-2078, 2000.
28. Stella P, Cusi D, Duzzi L, Bianchi G. Relations between hypertension and glomerulosclerosis in first-generation hybrid rats of the Milan strains. Child Nephrol Urol 11: 6-9, 1991.
29. Stoll M, Kwitek-Black AE, Cowley AWJ, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Res 10: 473-482, 2000.
30. Weir MR. Microalbuminuria and cardiovascular disease. Clin J Am Soc Nephrol 2: 581-590, 2007.
31. Zandi-Nejad K, Luyckx VA, Brenner BM. Adult hypertension and kidney disease: the role of fetal programming. Hypertension 47: 502-508, 2006.