Functional characterization of human aquaporin 9 as a facilitative glycerol carrier

Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 4, 2008, Pages 279-284

  Ohgusu, Yuriko ^a   Ohta, Kin Ya ^a   Ishii, Megumi ^a   Katano, Takahiro ^b   Urano, Kimihiko ^b   Watanabe, Jun ^b   Inoue, Katsuhisa ^a   Yuasa, Hiroaki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Aquaporin 9; Carrier; Facilitative transport; Glycerol; Liver; Oocyte expression system

Indexed keywords

ACYLGLYCEROL; AQUAPORIN 9; GLYCEROL; SODIUM ION; AQP9 PROTEIN, HUMAN; AQUAPORIN; CARRIER PROTEIN; SODIUM;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; MICHAELIS CONSTANT; MICHAELIS MENTEN KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; TEMPERATURE DEPENDENCE; TRANSPORT KINETICS; XENOPUS LAEVIS; ANIMAL; HUMAN; LIVER; METABOLISM; OOCYTE; PHYSIOLOGY; TEMPERATURE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; AQUAPORINS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; FEMALE; GLYCEROL; HUMANS; LIVER; OOCYTES; SODIUM; TEMPERATURE; XENOPUS LAEVIS;

EID: 56149088542     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.23.279     Document Type: Article

References (21)

1. Yuasa, H., Hamamoto, K., Dogu, S., Marutani, T., Nakajima, A., Kato, T., Hayashi, Y., Inoue, K. and Watanabe, J.: Saturable absorption of glycerol in the rat intestine. Biol. Pharm. Bull., 26: 1633-1636 (2003).
2. Kato, T., Hayashi, Y., Inoue, K. and Yuasa, H.: Functional characterization of the carrier-mediated transport system for glycerol in everted sacs of the rat small intestine. Biol. Pharm. Bull., 27: 1826-1830 (2004).
3. +-dependent carrier-mediated transport in the closed loop of the rat small intestine. Biol. Pharm. Bull., 28: 553-555 (2005).
4. Ohta, K., Inoue, K., Hayashi, Y. and Yuasa, H.: Carrier-mediated transport of glycerol in the perfused rat small intestine. Biol. Pharm. Bull., 29: 785-789 (2006).
5. +-dependent carrier-mediated transport. Biol. Pharm. Bull., 29: 150-154 (2006).
6. Fujimoto, N., Inoue, K., Ohgusu, Y., Hayashi, Y. and Yuasa, H.: Enhanced uptake of glycerol by butyrate treatment in HCT-15 human colon cancer cell line. Drug Metab. Pharmacokinet., 22: 195-198 (2007).
7. Fujimoto, N., Inoue, K., Hayashi, Y. and Yuasa, H.: Effect of glycerol-related compounds on carrier-mediated glycerol uptake in HCT-15 human colon cancer cell line. Drug Metab. Pharmacokinet., 23: 216-220 (2008).
8. Li, C.-C. and Lin, E. C. C.: Glycerol transport and phosphorylation by rat hepatocytes. J. Cell. Physiol., 117: 230-234 (1983).
9. Agre, P., Bonhivers, M. and Borgnia, M. J.: The aquaporins, blueprints for cellular plumbing systems. J. Biol. Chem.,273: 14659-14662 (1998).
10. Morishita, Y., Sakube, Y., Sasaki, S. and Ishibashi, K.: Molecular mechanisms and drug development in aquaporin water channel diseases: aquaporin superfamily (superaquaporins): expansion of aquaporins restricted to multicellular organisms. J. Pharmacol. Sci., 96: 276-279 (2004).
11. Hibuse, T., Maeda, N., Nagasawa, A. and Funahashi, T.: Aquaporins and glycerol metabolism. Biochim. Biophys. Acta, 1758: 1004-1011 (2006).
12. Brisson, D., Vohl, M.-C., St-Pierre, J., Hudson, T. J. and Gaudet, D.: Glycerol: a neglected variable in metabolic processes? Bioessays, 23: 534-542 (2001).
13. Inoue, K., Fei, Y. J., Zhuang, L., Gopal, E., Miyauchi, S. and Ganapathy, V.: Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for tricarboxylic acid cycle intermediates. Biochem J, 378: 949-957 (2004).
14. Maurel, C., Reizer, J., Schroeder, J. I., Chrispeels, M. J. and Saier, M. H.: Functional characterization of the Escherichia coli glycerol facilitator, GlpF, in Xenopus oocytes. J. Biol. Chem., 269: 11869-11872 (1994).
15. Tsukaguchi, H., Weremowicz, S., Morton, C. C. and Hediger, M. A.: Functional and molecular characterization of the human neutral solute channel aquaporin-9. Am. J. Physiol., 277: F685-F696 (1999).
16. Tsukaguchi, H., Shayakul, C., Berger, U. V., Mackenzie, B., Devidas, S., Guggino, W. B., van Hoek, A. N. and Hediger, M. A.: Molecular characterization of a broad selectivity neutral solute channel. J. Biol. Chem., 273: 24737-24743 (1998).
17. Huebert, R. C., Splinter, P. L., Garcia, F., Marinelli, R. A. and LaRusso, N. F.: Expression and localization of aquaporin water channels in rat hepatocytes. J. Biol. Chem., 277: 22710-22717 (2002).
18. Robergs, R. A. and Griffin, S. E.: Glycerol: biochemistry, pharmacokinetics and clinical and practical applications. Sports Med., 26: 145-167 (1998).
19. Echevarría, M., Windhager, E. E. and Frindt, G.: Selectivity of the renal collecting duct water channel aquaporin-3. J. Biol. Chem., 271: 25079-25082 (1996).
20. Kuriyama, H., Shimomura, I., Kishida, K., Kondo, H., Furuyama, N., Nishizawa, H., Maeda, N., Matsuda, M., Nagaretani, H., Kihara, S., Nakamura, T., Tochino, Y., Funahashi, T. and Matsuzawa, Y.: Coordinated regulation of fat-specific and liver specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes, 51: 2915-2921 (2002).
21. Carbrey, J. M., Gorelick-Feldman, D. A., Kozono, D., Praetorius, J., Nielsen, S. and Agre, P.: Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. Proc. Natl. Acad. Sci., U.S.A., 100: 2945-2950 (2003).