HL-37, a novel anthracene derivative, induces Ca2+-mediated apoptosis in human breast cancer cells

Toxicology

Volumn 254, Issue 1-2, 2008, Pages 68-74

  Xie, Song Qiang ^a   Zhang, Zhong Quan ^a   Hu, Guo Qiang ^a   Xu, Mei ^a   Ji, Bian Sheng ^a  

^a HENAN UNIVERSITY   (China)

Author keywords

Ca2+ i; Anthracene derivative; Apoptosis; Calpain; Caspase; Cytochrome c; Mitochondrial membrane potential; Oxidative stress

Indexed keywords

ANTHRACENE DERIVATIVE; CALCIUM; CALPAIN; CASPASE 3; CASPASE 4; CASPASE 7; CASPASE 9; CYTOCHROME C; HL 37; HYDROGEN PEROXIDE; MATRIX METALLOPROTEINASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CALCIUM CELL LEVEL; CANCER CELL; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANTHRACENES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS;

EID: 56049113988     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.09.021     Document Type: Article

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