Role of the domain encompassing Arg304-Ile328 in rat P2X2 receptor conformation revealed by alterations in complex glycosylation at Asn298

Biochemical Journal

Volumn 416, Issue 1, 2008, Pages 137-143

  Young, Mark T ^a   Zhang, Yi Hong ^b   Cao, Lishuang ^a   Broomhead, Helen ^a   Jiang, Lin Hua ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Ion channel; Pre transmembrane segment 2 (TM2); Scanning cysteine mutagenesis; Topology

Indexed keywords

ACCEPTOR SITES; CELL SURFACES; CYSTEINE SUBSTITUTIONS; ECTODOMAIN; EXTRACELLULAR; ION CHANNEL; N-GLYCAN; N-TERMINAL; P2X RECEPTORS; PATCH CLAMP RECORDING; PLASMA MEMBRANES; PRE-TRANSMEMBRANE SEGMENT 2 (TM2); TERMINAL PORTIONS; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; AMINES; AMINO ACIDS; BIOLOGICAL MEMBRANES; ESTERIFICATION; GLYCOSYLATION; MUTAGENESIS; ORGANIC ACIDS; PLASMAS; SCANNING;

CELL MEMBRANES;

ARGININE; ASPARAGINE; CYSTEINE; ION CHANNEL; ISOLEUCINE; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2 RECEPTOR;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CELL MEMBRANE; CELL STRAIN HEK293; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; GLYCOSYLATION; KIDNEY; PHYSIOLOGY; PRENATAL DEVELOPMENT; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; RAT;

RATTUS;

AMINO ACID SEQUENCE; ANIMALS; ASPARAGINE; GLYCOSYLATION; HUMANS; KIDNEY; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, PURINERGIC P2;

EID: 56049108808     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081182     Document Type: Article

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