Effects of berberine on renal function, oxidative stress and renal aldose reductase in rats with diabetic nephropathy

Chinese Pharmacological Bulletin

Volumn 24, Issue 7, 2008, Pages 955-959

  Liu, Wei Hua ^a   Huang, He Qing ^a   Deng, Yan Hui ^a   Li, Xue Juan ^a   Guo, Fen Fen ^a   Huang, Wen Ge ^a   Chen, Feng Ying ^a   Chen, Shao Rui ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Aldose reductase; Berberine; Diabetic nephropathy; Oxidative stress; Polyol pathway

Indexed keywords

ALDEHYDE REDUCTASE; BERBERINE; MALONALDEHYDE; MESSENGER RNA; POLYOL; STREPTOZOCIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD GLUCOSE MONITORING; BODY WEIGHT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; KIDNEY FUNCTION; KIDNEY MASS; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN URINE LEVEL; RAT; RENAL PROTECTION; STREPTOZOCIN DIABETES; UREA NITROGEN BLOOD LEVEL; WISTAR RAT;

EID: 56049096990     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Feng C G, Zhang L X, Liu X. Progress in research of aldose reductase inhibitors in traditional medicinal herbs[J]. China J Chin Mater Med, 2005,30(19):1496-500.
2. Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins[J]. Nat Med, 2004,10(12):1344-51.
3. Ko B S, Choi S B, Park S K, et al. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma[J]. Biol Pharm Bull, 2005,28(8):1431-7.
4. Gilbert R E, Cooper M E. The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury[J]? Kidney Int, 1999,56(5):1627-37.
5. Haneda M. Mechanisms for the development and progression of diabetic nephropathy[J]. Nippon Rinsho, 2006,64(Suppl 2):427-32.
6. Ohshiro Y, Takasu N. Molecular mechanism of diabetic nephropathy[J]. Nippon Rinsho, 2006,64(5):997-1003.
7. Chen H, Brahmbhatt S, Gupta A, Sharma A C. Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction[J]. Cardiovasc Diabetol,2005,4(1):3.
8. Yuan L, Wu Y G, Hao L, et al. Effect of total glucosides of paeony on the expression of intercellular adhesion molecule-1 and transforming growth factor I protein in the kidney in experimental diabetes[J]. Chin Pharmacol Bull, 2007,23(6):821-6.
9. + -ATPase activity of proximal tubule in early diabetic rats[J]. Chin Pharmacol Bull, 2007,23(7):917-20.
10. Yu H Y, Inoguchi T, Nakayama M, et al. Statin attenuates high glucose-induced and angiotensin II-induced MAP kinase activity through inhibition of NAD (P) H oxidase activity in cultured mesangial cells[J]. Med Chem, 2005,1(5):461-6.
11. Nakamara N, Obagashi H, Fujii M, et al. Induction of aldose reductase in cultured human microvascular endothelial cells by advanced glycation end products[J]. Free Radic Biol Med, 2000,29 (1):17-25.
12. Xu H Q, Liu H, Shen J, Shi Y. Influence of iridosides of cornus officinalis on glomerular mesangial cells cultured with AGEs[J]. Chin Pharmacol Bull, 2006,22(4):432-6.
13. Price S A, Agthong S, Middlemas A B, Tomlinson D R. Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy interactions with aldose reductase[J]. Diabetes, 2004,53(7):1851-6.
14. Stambe C, Atkins R C, Tesch G H, et al. Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis[J]. J Am Soc Nephrol, 2003,14(2):338-51.
15. Wang Q S, Zhang A L, Li R K, et al. High glucose stimulates synthesis of CTGF in HMC via SGK1 signaling pathway[J]. Chin Pharmacol Bull,2007,23(8):1015-20.
16. Jiang H J, Liu J S, Zhu Z H, et al. The effect and significance of candesartan on the SGK1 expression in murine diabetic nephropathy kidney[J]. Chin Pharmacol Bull, 2006,22(5):547-51.
17. Chaturvedi L S, Koul S, Sekhon A, et al. Oxalate selectively activates p38 mitogen-activated protein kinase and c-Jun N-terminal kinase signal transduction pathways in renal epithelial cells[J]. J Biol Chem, 2002,277(15):13321-30.
18. Yang X, Li C R, Zhu Z H, et al. Protective effect of EGCG on experimental diabetic nephropathy in rats[J]. Chin Pharmacol Bull, 2006,22(1):84-8.
19. Liu W H, Yang B, Tao S, et al. Protective effects of Jiaotai pill complex prescription on renal injury in diabetic rats [J]. Chin Pharmacol Bull, 2007,23(4):559-60.