Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model

Free Radical Research

Volumn 42, Issue 10, 2008, Pages 873-884

  Murugan, Ramalingam Senthil ^a   Uchida, Koji ^b   Hara, Yukihiko ^c   Nagini, Siddavaram ^a  

^a ANNAMALAI UNIVERSITY   (India)

^b NAGOYA UNIVERSITY   (Japan)

^c Mitsui Norin Co Ltd ^*  (Japan)

Author keywords

Antioxidants; Black tea polyphenols; Chemoprevention; Dimethylaminoazobenzene; Hepatocellular carcinoma; Oxidative stress; Xenobiotic metabolizing enzymes

Indexed keywords

4 DIMETHYLAMINOAZOBENZENE; 4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; BLACK TEA EXTRACT; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME B5; CYTOCHROME B5 REDUCTASE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B; DNA; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID; LIPID HYDROPEROXIDE; LYSINE; MANGANESE SUPEROXIDE DISMUTASE; POLYPHENOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THIOBARBITURIC ACID REACTIVE SUBSTANCE; TYROSINE; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DISEASE MODEL; DNA ADDUCT; DRUG EFFICACY; INHIBITION KINETICS; LIPID OXIDATION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; OXIDATIVE STRESS; PRECANCER; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CAMELLIA SINENSIS; DNA ADDUCTS; ENZYMES; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS, EXPERIMENTAL; MALE; OXIDATIVE STRESS; P-DIMETHYLAMINOAZOBENZENE; PHENOLS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; XENOBIOTICS;

CAMELLIA SINENSIS; RATTUS;

EID: 55849147358     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760802506331     Document Type: Article

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