Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/β-catenin pathway

Toxicology and Applied Pharmacology

Volumn 227, Issue 1, 2008, Pages 136-146

  Patel, Rachana ^a   Ingle, Arvind ^a   Maru, Girish B ^a  

^a TATA MEMORIAL HOSPITAL   (India)

Author keywords

catenin; 1,2 dimethylhydrazine; Anti carcinogenic activity; Anti proliferation; Colorectal carcinogenesis; PBP extract

Indexed keywords

1,2 DIMETHYLHYDRAZINE; BETA CATENIN; BLACK TEA EXTRACT; CYCLIN D1; CYCLOOXYGENASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; POLYPHENOL DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CHEMOPROPHYLAXIS; COLORECTAL CANCER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; TUMOR VOLUME;

1,2-DIMETHYLHYDRAZINE; ANIMALS; BETA CATENIN; CARCINOGENS; CELL PROLIFERATION; COLON; COLORECTAL NEOPLASMS; FLAVONOIDS; LIVER; MALE; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; TEA; WNT PROTEINS;

CAMELLIA SINENSIS; RATTUS;

EID: 38749114296     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.10.009     Document Type: Article

References (44)

1. Afaq F., Saleem M., Aziz M.H., and Mukhtar H. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin. Toxicol. Appl. Pharmacol. 195 (2004) 361-369
2. Ahnen D.J. The genetic basis of colorectal cancer risk. Adv. Intern. Med. 14 (1996) 531-552
3. Arab L., and IL'Yasova D. The epidemiology of tea consumption and colorectal cancer incidence. J. Nutr. 133 (2003) 3310S-3318S
4. Baron J.A., Sandler R.S., Bresalier R.S., Quan H., Riddell R., Lanas A., Bolognese J.A., Oxenius B., Horgan K., Loftus S., and Morton D.G. A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas. Gastroenterology 131 (2006) 1674-1682
5. Begleiter A., Sivananthan K., Curphey T.J., and Bird R.P. Induction of NAD(P)H quinone:oxidoreductase 1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats. Cancer Epidemiol. Biomark. Prev. 22 (2003) 566-572
6. Benson A.M., Hunkeler M.J., and Talalay P. Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc. Natl. Acad. Sci. 77 (1980) 216-220
7. Blot W.J., Mclaughlin J.K., and Chow W.H. Cancer rates among drinkers of black tea. Crit. Rev. Food Sci. Nutr. 37 (1997) 739-760
8. Bode A.M., and Dong Z. Signal transduction pathways: targets for chemoprevention of skin cancer. Lancet Oncol. 1 (2000) 181-188
9. Brown A., Eyton W., Holmes A., and Ollis W. Identification of the thearubigins as polymeric proanthocyanidins. Nature 221 (1969) 742-744
10. Caderni G., De Filippo C., Luceri C., Salvadori M., Giannini A., Biggeri A., Remy S., Cheynier V., and Dolara P. Effects of black tea, green tea and wine extracts on intestinal carcinogenesis induced by azoxymethane in F344 rats. Carcinogenesis 21 (2000) 1965-1969
11. Castellone M.D., Teramoto H., and Gutkind J.S. Cyclooxygenase-2 and colorectal cancer chemoprevention: the β-catenin connection. Cancer Res. 66 (2006) 11085-11088
12. Challa A., Rao D.R., and Reddy B.S. Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea. Carcinogenesis 18 (1997) 2023-2026
13. Dashwood W.M., Orner G.A., and Dashwood R.H. Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochem. Biophys. Res. Commun. 296 (2002) 584-588
14. Emerich S.F. Investigations into metabolism and mode of action of the colon carcinogen 1,2-dimethylhydrazine. Cancer 36 (1975) 2407-2412
15. Endo T., Ookawa K., Tanaka M., Nakaji S., Tsuchida S., and Sugawara K. Differences in carcinogenesis by the length of carcinogen exposure period in rat colon. Dis. Dig. Sci. 46 (2001) 109-117
16. Gescher A. Polyphenolic phytochemicals versus non-steroidal anti-inflammatory drugs: which are better cancer chemopreventive agents?. J. Chemother. 16 Suppl. 4 (2004) 3-6
17. Gibson P.R., Van de Pol E., Maxwell L.E., Gabriel A., and Doe W.F. Isolation of colonic crypts that maintain structural and metabolic viability in vitro. Gastroenterology 96 (1989) 283-291
18. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The first step in mercapteuric acid formation. J. Biol. Chem. 249 (1974) 7130-7139
19. Half E.E., and Arber N. Chemoprevention of colorectal cancer: two steps forward, one step back?. Future Oncol. 6 (2006) 697-704
20. Hall P.A., Levison D.A., Woods A.L., Yu C.W., Kellock D.B., Watkins J.A., Barnes D.M., Gillett C.E., Camplejohn R., Dover R., Waseem N.H., and Lane D.P. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: index of cell proliferation with evidence of deregulated expression in some neoplasms. J. Pathol. 162 (1990) 285-290
21. Haslam E. Thoughts on thearubigins. Phytochemistry 64 (2003) 61-73
22. Huls G., Koornstra J.J., and Kleibeuker J.H. Non-steroidal anti-inflammatory drugs and molecular carcinogenesis of colorectal carcinomas. Lancet 362 (2003) 230-232
23. IARC, 1991. Tea. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Human-Coffee, Tea, Mate, Methylxanthines, Methylglyoxal, vol. 51. Lyon, France, pp. 207-271.
24. Jia X.D., and Han C. Chemoprevention of tea on colorectal cancer induced by dimethylhydrazine in Wistar rats. World J. Gastroenterol. 6 (2000) 699-703
25. Katoh M. Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol. Ther. 5 (2006) 1059-1064
26. Krishnan R., and Maru G.B. Isolation and analyses of polymeric polyphenol fractions from black tea. Food Chem. 94 (2006) 331-340
27. Krishnan R., Raghunathan R., and Maru G.B. Effects of polymeric black tea polyphenols on benzo(a)pyrene [B(a)P]-induced cytochrome P4501A1 and 1A2 in mice. Xenobiotica 35 (2005) 671-682
28. Kumar N., Shibata D., Helm J., Coppola D., and Malafa M. Green tea polyphenols in the prevention of colon cancer. Front. Biosci. 12 (2007) 2309-2315
29. Lambert J.D., Hong J., Yang G.Y., Liao J., and Yang C.S. Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am. J. Clin. Nutr. 81 (2005) 284-915
30. Licato L.L., Keku T.O., Wurzelmann J.I., Murray S.C., Woosley J.T., Sandler R.S., and Brenner D.A. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Gastroenterology 113 (1997) 1589-1598
31. Lodovici M., Casalini C., De Filippo C., Copeland E., Xu X., Clifford M., and Dolara P. Inhibition of 1,2-dimethylhydrazine-induced oxidative DNA damage in rat colon mucosa by black tea complex polyphenols. Food Chem. Toxicol. 38 (2000) 1085-1088
32. Miller R.J., Hocking A.M., Brown J.D., and Moon R.T. Mechanism and signal transduction by Wnt/beta-catenin and Wnt/Ca2+ pathways. Oncogene 18 (1999) 7860-7872
33. Orford K., Crockett C., Jensen J.P., Weissman A.M., and Byers S.W. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J. Biol. Chem. 272 (1997) 24735-24738
34. Oving I.M., and Clevers H.C. Molecular causes of colon cancer. Eur. J. Clin. Investig. 32 (2002) 448-487
35. Patel R., Garg R., Erande S., and Maru G.B. Chemopreventive herbal anti-oxidants: current status and future perspectives. J. Clin. Biochem. Nutr. 40 (2007) 82-91
36. Peng G., Wargovich M.J., and Dixon D.A. Anti-proliferative effects of green tea polyphenol EGCG on Ha-Ras-induced transformation of intestinal epithelial cells. Cancer Lett. 238 (2006) 260-270
37. Pool-Zobel B., Veeriah S., and Bohmer F.D. Modulation of xenobiotic metabolising enzymes by anticarcinogens-focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. Mutat. Res. 591 (2005) 74-92
38. Sang S., Tian S., Stark R.E., Yang C.S., and Ho C.T. New dibenztropolone derivatives characterized from black tea using LC/MS/MS. Bioorg. Med. Chem. 12 (2004) 3009-3017
39. Sengupta A., Ghosh S., Das R.K., Bhattacharjee S., and Bhattacharya S. Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. Eur. J. Cancer Prev. 15 (2006) 301-305
40. Sheng H., Shao J., Williams C.S., Pereira M.A., Taketo M.M., Oshima M., Reynolds A.B., Washington M.K., DuBois R.N., and Beauchamp R.D. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis 19 (1998) 543-549
41. Steele V.E., Hawk E.T., Viner J.L., and Lubet R.A. Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer. Mutat. Res. 523-524 (2003) 137-144
42. Stopera S.A., Murphy L.C., and Bird R.P. Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer. Carcinogenesis 13 (1992) 2081-2085
43. Sun C.L., Yuan J.M., Koh W.P., and Yu M.C. Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies. Carcinogenesis 27 (2006) 1301-1309
44. Wong N.A.C.S., and Pignatelli M. β-catenin-a linchpin in colorectal carcinogenesis?. Am. J. Pathol. 160 (2002) 389-401