pH-Sensitive hydrogels of dextran: Synthesis, characterization and in vivo studies

Journal of Drug Targeting

Volumn 16, Issue 9, 2008, Pages 649-659

  Giannuzzo, Maria ^a   Corrente, Federica ^a   Feeney, Michelle ^a   Paoletti, Luigi ^b   Paolicelli, Patrizia ^a   Tita, Beatrice ^a   Vitali, Federica ^a   Casadei, Maria Antonietta ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Colon delivery; Dextran; Ibuprofen; In vivo studies; pH Sensitive hydrogels; Photo chemical cross linking

Indexed keywords

DEXTRAN DERIVATIVE; DEXTRAN METHACRYLATE PHTHALATE; IBUPROFEN; POLYSORBATE 80; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG STABILITY; HYDROGEL; HYDROLYSIS; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; STOMACH PROTECTION; STOMACH ULCER; SYNTHESIS;

ANIMALS; DEXTRANS; DRUG DELIVERY SYSTEMS; HYDROGELS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IBUPROFEN; MALE; METHACRYLATES; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; STOMACH DISEASES;

EID: 55849134808     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860802201191     Document Type: Article

References (17)

1. Burdan, F., Szumilo, J., Kleeacz, R., Dudka, J., Korobowicz, A., Tokarska, E., Cendrowska-Pincosz, M., Medej, B. and Klepacz, L. (2004) Gastrointestinal and hepatic toxicity of selective and non-selective cyclooxygenase-2 inhibitors in pregnant and non-pregnant rats. Pharm Res, 50, pp. 533-543.
2. Drury, JL and Mooney, DJ (2003) Hydrogels for tissue engineering: Scaffold design variables and applications. Biomaterials, 24, pp. 4337-4351.
3. Franssen, O., Vos, OP and Hennink, WE (1997) Delayed release of a model protein from enzymatically-degrading dextran hydrogels. J Control Release, 44, pp. 237-245.
4. Franssen, O., van Ooijenr, RD, de Boer, D., Maesr, AA and Hennink, WE (1999) Enzymatic degradation of cross-linked dextrans. Macromolecules, 32, pp. 2896-2902.
5. Freitas, MA and Marchetti, JM (2005) Nimesulide PLA microspheres as a potential sustained release system for the treatment of inflammatory diseases. Drug Discov Today, 7, pp. 569-579.
6. Giannuzzo, M., Feeney, M., Paolicelli, P. and Casadei, MA (2006) Synthesis and characterization of pH-sensitive hydrogels of dextran. J Drug Deliv Sci Tech, 16, pp. 49-54.
7. Gupta, P., Vermani, K. and Garg, S. (2002) Hydrogels: From controlled release to pH-responsive drug delivery. Drug Discov Today, 7, pp. 569-579.
8. Hennink, WE, Franssen, O., Van Dijk-Wolthuis, WNE and Talsma, H. (1997) Dextran hydrogels for the controlled release of proteins. J Control Release, 48, pp. 107-114.
9. Hoffman, AS (2002) Hydrogels for biomedical applications. Adv Drug Deliv Rev, 3, pp. 3-12.
10. Kamath, KR and Park, K. (1993) Biodegradable hydrogels in drug delivery. Adv Drug Deliv Rev, 11, pp. 59-84.
11. Kim, SH and Chu, CC (2000) Synthesis and characterization of dextran methacrylate hydrogels and structural studies by SEM. J Biomed Mater Res, 49, pp. 517-527.
12. Magistretti, MJ, Conti, M. and Crostoni, A. (1988) Antiulcer activity of an anthocyanidin from Vaccinium myrtillus. Arzneimittelforschung, 38, pp. 686-690.
13. Peppas, NA, Bures, P., Leobandung, W. and Ichikawa, H. (2000) Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm, 50, pp. 27-46.
14. Pitarresi, G., Palombo, FS, Giammona, G., Casadei, MA and Micheletti Moracci, F (2003) Biodegradable hydrogels obtained by photocrosslinking of dextran and polyaspartamide derivatives. Biomaterials, 24, pp. 4301-4313.
15. Pitarresi, G., Casadei, MA, Mandracchia, D., Paolicelli, P., Palombo, FS and Giammona, G. (2007) Photocrosslinking of dextran and polyaspartamide derivatives: A combination suitable for colon-specific delivery. J Control Release, 119, pp. 328-338.
16. Rao, CM, Ramesh, KV, Bairy, KL and Kulkarni, DR (1990) Zinc complexes of NSAID's abolish gastric ulceration propensity of parent drugs. Indian Drugs, 28, pp. 64-67.
17. Van Dijk-Wolthuis, WNE, Ketteness-Van Den Bosch, JJ, Van Der Kerk-Van Hoof, A and Hennink, WE (1997) Reaction of dextran with glycidyl methacrylate: An unexpected transesterification. Macromolecules, 30, pp. 3411-3413.