The relationship between homozygosity and the frequency of the most frequent allele

Genetics

Volumn 179, Issue 4, 2008, Pages 2027-2036

  Rosenberg, Noah A ^a,b   Jakobsson, Mattias ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA;

ALLELE; ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; HOMOZYGOSITY; HUMAN; POPULATION GENETICS; PRIORITY JOURNAL; GENETIC POLYMORPHISM; HAPLOTYPE; HOMOZYGOTE; STATISTICAL MODEL;

GENE FREQUENCY; GENETICS, POPULATION; HAPLOTYPES; HOMOZYGOTE; HUMANS; MICROSATELLITE REPEATS; MODELS, STATISTICAL; POLYMORPHISM, GENETIC;

EID: 55749112151     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.107.084772     Document Type: Article

References (16)

1. DEPAULIS, F., and M. VEUILLE, 1998 Neutrality tests based on the distribution of haplotypes under an infinite-site model. Mol. Biol. Evol. 15: 1788-1790.
2. DEPAULIS, F., S. MOUSSET and M. VEUILLE, 2001 Haplotype tests using coalescent simulations conditional on the number of segregating sites. Mol. Biol. Evol. 18: 1136-1138.
3. HEDRICK, P. W., 2005 A standardized genetic differentiation measure. Evolution 59: 1633-1638.
4. HUDSON, R. R., K. BAILEY, D. SKARECKY, J. KWIATOWSKI and F. J. AYALA, 1994 Evidence for positive selection in the superoxide dismutase (Sod) region of Drosophila melanogaster. Genetics 136: 1329-1340.
5. INNAN, H., K. ZHANG, P. MARJORAM, S. TAVARÉ and N. A. ROSENBERG, 2005 Statistical tests of the coalescent model based on the haplotype frequency distribution and the number of segregating sites. Genetics 169: 1763-1777.
6. LONG, J. C., and R. A. KITTLES, 2003 Human genetic diversity and the nonexistence of biological races. Hum. Biol. 75: 449-471.
7. MARKOVTSOVA, L., P. MARJORAM and S. TAVARÉ, 2001 On a test of Depaulis and Veuille. Mol. Biol. Evol. 18: 1132-1133.
8. NEI, M., 1987 Molecular Evolutionary Genetics. Columbia University Press, New York.
9. ROSENBERG, N. A., S. MAHAJAN, S. RAMACHANDRAN, C. ZHAO, J. K. PRITCHARD et al., 2005 Clines, clusters, and the effect of study design on the inference of human population structure. PLoS Genet. 1: 660-671.
10. SABETI, P. C., D. E. REICH, J. M. HIGGINS, H. Z. P. LEVINE, D. J. RICHTER et al., 2002 Detecting recent positive selection in the human genome from haplotype structure. Nature 419: 832-837.
11. TANG, K., K. R. THORNTON and M. STONEKING, 2007 A new approach for using genome scans to detect recent positive selection in the human genome. PLoS Biol. 5: 1587-1602.
12. TOOMAJIAN, C., T. T. HU, M. J. ARANZANA, C. LISTER, C. TANG et al., 2006 A nonparametric test reveals selection for rapid flowering in the Arabidopsis genome. PLoS Biol. 4: 732-738.
13. VOIGHT, B. F., S. KUDARAVALLI, X. WEN and J. K. PRITCHARD, 2006 A map of recent positive selection in the human genome. PLoS Biol. 4: 446-458.
14. WATTERSON, G. A., 1977 Heterosis or neutrality? Genetics 85: 789-814.
15. WATTERSON, G. A., 1978 The homozygosity test of neutrality. Genetics 88: 405-417.
16. ZENG, K., S. MANO, S. SHI and C.-I. WU, 2007 Comparisons of site-and haplotype-frequency methods for detecting positive selection. Mol. Biol. Evol. 24:1562-1574.