Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 23, 2008, Pages 10034-10042

  Martini, Elisabetta ^a   Norcini, Monica ^b   Ghelardini, Carla ^b   Manetti, Dina ^a   Dei, Silvia ^a   Guandalini, Luca ^a   Melchiorre, Michele ^a   Pagella, Simona ^a   Scapecchi, Serena ^a   Teodori, Elisabetta ^a   Romanelli, Maria Novella ^a  

^a Laboratory of Design   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cognition enhancers; Cognition modulators; Mouse passive avoidance test; Sunifiram

Indexed keywords

CYCLOHEXANE DERIVATIVE; DM 232; DM 235; MC 68; MN 19; NOOTROPIC AGENT; PIRACETAM; SAPUNIFIRAM; SCOPOLAMINE; SUNIFIRAM; UNCLASSIFIED DRUG; UNIFIRAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; COGNITION; DOSE RESPONSE; DRUG DESIGN; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PASSIVE AVOIDANCE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; AVOIDANCE LEARNING; DATA INTERPRETATION, STATISTICAL; DRUG DESIGN; MICE; NOOTROPIC AGENTS; PIPERAZINES; PYRROLES; RECOGNITION (PSYCHOLOGY);

EID: 55749107805     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.017     Document Type: Article

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