Synthesis, acoustic stability, and pharmacologic activities of papaverine-loaded echogenic liposomes for ultrasound controlled drug delivery

Journal of Liposome Research

Volumn 18, Issue 4, 2008, Pages 263-277

  Kee, Patrick H ^a,d   Abruzzo, Todd A ^b   Smith, Denise A B ^b   Kopechek, Jonathan A ^b   Wang, Boyu ^b   Huang, Shaoling L ^a   MacDonald, Robert C ^c   Holland, Christy K ^b   McPherson, David D ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d Department of Internal Medicine   (United States)

Author keywords

Drug encapsulation; Liposomes; Papaverine; Ultrasound contrast agents

Indexed keywords

LIPOSOME; PAPAVERINE; PHOSPHODIESTERASE INHIBITOR;

ACOUSTICS; ARTICLE; BLOOD FLOW; CONCENTRATION (PARAMETERS); DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MECHANISM; DRUG RELEASE; DRUG STABILITY; DRUG SYNTHESIS; ECHOGRAPHY; ENCAPSULATION; HYDRATION; IMAGE ANALYSIS; PRIORITY JOURNAL; SYSTEMIC CIRCULATION;

ACOUSTICS; ANIMALS; CATTLE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; LIPOSOMES; PAPAVERINE; PARTICLE SIZE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; ULTRASONICS;

EID: 55749094536     PISSN: 08982104     EISSN: 15322394     Source Type: Journal    
DOI: 10.1080/08982100802354558     Document Type: Article

References (37)

1. Alkan-Onyuksel, H., Demos, S. M., Lanza, G. M., Vonesh, M. J., Klegerman, M. E., Kane B. J., Kuszak, J., McPherson, D. D. (1996). Development of inherently echogenic liposomes as an ultrasonic contrast agent. J Pharm Sci 85:486-90.
2. Allen, T. M. (1998). Liposomal drug formulations. Rationale for development and what we can expect for the future. Drugs 56:747-56.
3. Andaluz, N., Tomsick, T. A., Tew, J. M., Jr., van Loveren, H. R., Yeh, H. S., Zuccarello, M. (2002). Indications for endovascular therapy for refractory vasospasm after aneurysmal subarachnoid hemorrhage: Experience at the University of Cincinnati. Surg Neurol 58:131-8.
4. Coussios, C. C., Holland, C. K., Jakubowska, L., Huang, S. L., MacDonald, R, C., Nagaraj, A., McPherson, D. D. (2004). In vitro characterization of liposomes and Optison by acoustic scattering at 3.5 MHz. Ultrasound Med Biol 30:181-90.
5. Fandino, J., Kaku, Y., Schuknecht, B., Valavanis, A., Yonekawa, Y. (1998). Improvement of cerebral oxygenation patterns and metabolic validation of superselective intraarterial infusion of papaverine for the treatment of cerebral vasospasm. Journal of Neurosurgery 89:93-100.
6. Firlik, K., Kaufmann, A., Firlik, A., Jungreis, C., Yonas, H. (1999). Intra-arterial papaverine for the treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Surgical Neurology 51:66-74.
7. Fry, D. W., White, J. C., Goldman, I. D. (1978). Rapid separation of low molecular weight solutes from liposomes without dilution. Anal Biochem 90:809-15.
8. Hamilton, A., Huang, S. L., Warnick, D., Stein, A., Rabbat, M., Madhav, T., Kane, B., Nagaraj, A., Klegerman, M., McDonald, R., McPherson, D. (2002). Left ventricular thrombus enhancement after intravenous injection of echogenic immunoliposomes: Studies in a new experimental model. Circulation 105:2772-8.
9. Hamilton, A. J., Huang, S. L., et al. (2004). Intravascular ultrasound molecular imaging of atheroma components in vivo. J Am Coll Cardiol 43:453-60.
10. Huang, S., McPherson, D. D., MacDonald, R. C. (2007). Multi-functional echogenic liposomes for image-guided and ultrasound-controlled PPAR agonist delivery. J Am Coll Cardiol 49:365A.
11. Huang, S. L., Hamilton, A. J., Nagaraj, A., Tiukinhoy, S. D., Klegerman, M. E., McPherson, D. D., MacDonald, R. C. (2001). Improving ultrasound reflectivity and stability of echogenic liposomal dispersions for use as targeted ultrasound contrast agents. J Pharm Sci 90:1917-26.
12. Huang, S. L. and MacDonald, R. C. (2004). Acoustically active liposomes for drug encapsulation and ultrasound-triggered release. Biochim Biophys Acta 1665:134-41.
13. Juliano, R. and Layton, D. (1980): Drug delivery systems: Characteristics and biomedical applications. London: Oxford University Press, 189-236.
14. Kassell, N. F., Helm, G., Simmons, N., Phillips, C. D., Cail, W. S. (1992). Treatment of cerebral vasospasm with intra-arterial papaverine. J Neurosurg 77:848-52.
15. Kopechek, J. A., Abruzzo, T. M., Wang, B., Chrzanowski, S. M., Smith, D. A., Kee, P., Huang, S., Collier, J., McPherson, D. D., Holland, C. K. (2008). Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes. J Ultrasound Med: In Press.
16. Liu, H. M. and Tu, Y. K. (2002). The efficacy of papaverine administration by different routes for the treatment of experimental acute cerebral vasospasm. J Clin Neurosci 9:561-5.
17. Liu, J. K., Tenner, M. S., Gottfried, O. N., Stevens, E. A., Rosenow, J. M., Madan, N., MacDonald, J. D., Kestle, J. R., Couldwell, W. T. (2004). Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm. J Neurosurg 100:414-21.
18. Meltzer, R. S., Tickner, E. G., Popp, R. L. (1980). Why do the lungs clear ultrasonic contrast? Ultrasound Med Biol 6: 263-9.
19. Milburn, J., Moran, C., Cross, D., Diringer, M., Pilgrim, T., Dacey, R. (1998). Increase in diameters of vasospastic intracranial arteries by intraarterial papaverine administration. J Neurosurg 88:38-42.
20. Minami, H., Kuwamura, K., Tamaki, N. (2001). Intraarterial infusion of papaverine and change of cerebral hemodynamics in symptomatic cerebral vasospasm. Kobe J Med Sci 47: 169-79.
21. Mizushige, K., Kondo, I., Ohmori, K., Hirao, K., Matsuo, H. (1999). Enhancement of ultrasound-accelerated thrombolysis by echo contrast agents: dependence on microbubble structure. Ultrasound Med Biol 25:1431-7.
22. Oskouian, R. J., Jr., Martin, N. A., Lee, J. H., Glenn, T. C., Guthrie, D., Gonzalez, N. R., Afari, A., Vinuela, F. (2002). Multimodal quantitation of the effects of endovascular therapy for vasospasm on cerebral blood flow, transcranial doppler ultrasonographic velocities, and cerebral artery diameters. Neurosurgery 51:30-43.
23. Park, J. W., Benz, C. C., Martin, F. J. (2004). Future directions of liposome- and immunoliposome-based cancer therapeutics. Semin Oncol 31:196-205.
24. Porter, T. M., Smith, D. A., Holland, C. K. (2006). Acoustic techniques for assessing the Optison destruction threshold. J Ultrasound Med 25:1519-29.
25. Scroop, R., Britz, G. W., West, G. A. (2004): Endovascular Therapy for Vasospasm Associated with Subarachnoid Hemorrhage. Management of Cerebral Aneurysms. HR Winn and P LeRoux. Philadelphia: Saunders: 489-498.
26. Smith, D. A., Porter, T. M., Martinez, J., Huang, S., MacDonald, R. C., McPherson, D. D., Holland, C. K. (2007). Destruction thresholds of echogenic liposomes with clinical diagnostic ultrasound. Ultrasound Med Biol 33:797-809.
27. Smith, D. A. B., Vaidya, S., Kopechek, J. A., Holland, C. K. (2007). Echogenic liposomes loaded with recombinant tissue-type plasminogen activator (rt-PA) for image-guided, ultrasound-triggered drug release. J Acoust Soc Am 122:3007.
28. Smith, T. P. and Enterline, D. S. (2000). Endovascular treatment of cerebral vasospasm. J Vasc Interv Radiol 11:547-59.
29. Srinivasan, J., Eskridge, J., Grady, M. S., Newell, D. W., Winn, H. R. (2002). Endovascular therapy for vasospasm. Clin Neurosurg 49:261-73.
30. Szebeni, J., Fontana, J. L., Wassef, N. M., Mongan, P. D., Morse, D. S., Dobbins, D. E., Stahl, G. L., Bunger, R., Alving, C. R. (1999). Hemodynamic changes induced by liposomes and liposome-encapsulated hemoglobin in pigs: a model for pseudoallergic cardiopulmonary reactions to liposomes. Role of complement and inhibition by soluble CR1 and anti-C5a antibody. Circulation 99:2302-9.
31. Tachibana, K. and Tachibana, S. (1995). Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. Circulation 92:1148-50.
32. Tiukinhoy, S. D., Khan, A. A., Huang, S., Klegerman, M. E., MacDonald, R. C., McPherson, D. D. (2004). Novel echogenic drug-immunoliposomes for drug delivery. Invest Radiol 39:104-10.
33. Tiukinhoy-Laing, S. D., Huang, S., Klegerman, M., Holland, C. K., McPherson, D. D. (2007). Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes. Thromb Res 119:777-84.
34. Unger, E. C., McCreery, T. P., Sweitzer, R. H., Caldwell, V. E., Wu, Y. (1998). Acoustically active lipospheres containing paclitaxel: A new therapeutic ultrasound contrast agent. Invest Radiol 33:886-92.
35. Vajkoczy, P., Horn, P., Bauhuf, C., Munch, E., Hubner, U., Ing, D., Thome, C., Poeckler-Schoeninger, C., Roth, H., Schmiedek, P. (2001). Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral vasospasm. Stroke 32:498-505.
36. Wasan, K. M. and Lopez-Berestein, G. (1995). The past, present, and future uses of liposomes in treating infectious diseases. Immunopharmacol Immunotoxicol 17:1-15.
37. Zhao, Y. Z., Liang, H. D., Mei, X. G., Halliwell, M. (2005). Preparation, characterization and in vivo observation of phospholipid-based gas-filled microbubbles containing hirudin. Ultrasound Med Biol 31:1237-43.