메뉴 건너뛰기




Volumn 8, Issue 2, 2008, Pages 65-72

Role of DNA repair systems in malignant tumor development in the elderly

Author keywords

Aging; Carcinoma; Hypermethylation; Singlenu cleotide polymorphism

Indexed keywords

MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 55749093419     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/j.1447-0594.2008.00450.x     Document Type: Review
Times cited : (7)

References (61)
  • 1
    • 0034626769 scopus 로고    scopus 로고
    • The age of cancer
    • DePinho RA. The age of cancer. Nature 2000; 408: 248-254.
    • (2000) Nature , vol.408 , pp. 248-254
    • DePinho, R.A.1
  • 2
    • 0030937307 scopus 로고    scopus 로고
    • Malignant tumors in a Japanese geriatric hospital
    • (In Japanese with English abstract.)
    • Mori M, Hashimoto H, Takahashi T et al. Malignant tumors in a Japanese geriatric hospital. Nippon Ronen Igakkai Zasshi 1997; 34: 130-134. (In Japanese with English abstract.)
    • (1997) Nippon Ronen Igakkai Zasshi , vol.34 , pp. 130-134
    • Mori, M.1    Hashimoto, H.2    Takahashi, T.3
  • 3
    • 21244465481 scopus 로고    scopus 로고
    • Cancer and aging: Symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo
    • Kitagawa M, Utsuyama M, Kurata M et al. Cancer and aging: Symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo. Cancer Immunol Immunother 2005; 54: 623-634.
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 623-634
    • Kitagawa, M.1    Utsuyama, M.2    Kurata, M.3
  • 4
    • 0037202597 scopus 로고    scopus 로고
    • Coding variants in human double-strand break DNA repair genes
    • Ruttan CC, Glickman BW. Coding variants in human double-strand break DNA repair genes. Mutat Res 2002; 509: 175-200.
    • (2002) Mutat Res , vol.509 , pp. 175-200
    • Ruttan, C.C.1    Glickman, B.W.2
  • 5
    • 57249104608 scopus 로고    scopus 로고
    • Minister's Secretariat, Statistics and Information Department, Ministry of Health, Labour and Welfare of Japan. Tokyo: Health and Welfare Statistics Association, 2004; 136-153
    • Minister's Secretariat, Statistics and Information Department, Ministry of Health, Labour and Welfare of Japan. Vital Statistics of Japan, Vol. 3. Tokyo: Health and Welfare Statistics Association, 2004; 136-153.
    • (2004) Vital Statistics of Japan , vol.3 , pp. 136-153
  • 7
    • 0033949360 scopus 로고    scopus 로고
    • Pathologic characteristics of colorectal cancer in the elderly: A retrospective study of 947 surgical cases
    • Arai T, Takubo K, Sawabe M, Esaki Y. Pathologic characteristics of colorectal cancer in the elderly: A retrospective study of 947 surgical cases. J Clin Gastroenterol 2000; 31: 67-72.
    • (2000) J Clin Gastroenterol , vol.31 , pp. 67-72
    • Arai, T.1    Takubo, K.2    Sawabe, M.3    Esaki, Y.4
  • 8
    • 0035206442 scopus 로고    scopus 로고
    • Multiple colorectal cancers in the elderly: A retrospective study of both surgical and autopsy cases
    • Arai T, Sawabe M, Takubo K, Kanazawa K, Esaki Y. Multiple colorectal cancers in the elderly: A retrospective study of both surgical and autopsy cases. J Gastroenterol 2001; 36: 748-752.
    • (2001) J Gastroenterol , vol.36 , pp. 748-752
    • Arai, T.1    Sawabe, M.2    Takubo, K.3    Kanazawa, K.4    Esaki, Y.5
  • 9
    • 4744361484 scopus 로고    scopus 로고
    • Pathologic characteristics of gastric cancer in the elderly: A retrospective study of 994 surgical patients
    • Arai T, Esaki Y, Inoshita N et al. Pathologic characteristics of gastric cancer in the elderly: A retrospective study of 994 surgical patients. Gastric Cancer 2004; 7: 154-159.
    • (2004) Gastric Cancer , vol.7 , pp. 154-159
    • Arai, T.1    Esaki, Y.2    Inoshita, N.3
  • 10
    • 34249797029 scopus 로고    scopus 로고
    • Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly
    • Arai T, Takubo K. Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly. Pathol Int 2007; 57: 303-314.
    • (2007) Pathol Int , vol.57 , pp. 303-314
    • Arai, T.1    Takubo, K.2
  • 11
    • 0035124351 scopus 로고    scopus 로고
    • Genetic and epigenetic changes in stomach cancer
    • Yokozaki H, Yasui W, Tahara E. Genetic and epigenetic changes in stomach cancer. Int Rev Cytol 2001; 204: 49-95.
    • (2001) Int Rev Cytol , vol.204 , pp. 49-95
    • Yokozaki, H.1    Yasui, W.2    Tahara, E.3
  • 12
    • 0842278570 scopus 로고    scopus 로고
    • Epigenetic changes in colorectal cancer
    • Kondo Y, Issa JP. Epigenetic changes in colorectal cancer. Cancer Metastasis Rev 2004; 23: 29-39.
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 29-39
    • Kondo, Y.1    Issa, J.P.2
  • 13
    • 0035477897 scopus 로고    scopus 로고
    • Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development
    • Nakagawa H, Nuovo GJ, Zervos EE et al. Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res 2001; 61: 6991-6995.
    • (2001) Cancer Res , vol.61 , pp. 6991-6995
    • Nakagawa, H.1    Nuovo, G.J.2    Zervos, E.E.3
  • 14
    • 0036861019 scopus 로고    scopus 로고
    • DNA methylation in cancer and ageing
    • Yuasa Y. DNA methylation in cancer and ageing. Mech Ageing Dev 2002; 123: 1649-1654.
    • (2002) Mech Ageing Dev , vol.123 , pp. 1649-1654
    • Yuasa, Y.1
  • 15
    • 0343399664 scopus 로고    scopus 로고
    • Poorly differentiated colonic adenocarcinoma, medullary type: Clinical, phenotypic, and molecular characteristics
    • Ruschoff J, Dietmaier W, Luttges J et al. Poorly differentiated colonic adenocarcinoma, medullary type: Clinical, phenotypic, and molecular characteristics. Am J Pathol 1997; 150: 1815-1825.
    • (1997) Am J Pathol , vol.150 , pp. 1815-1825
    • Ruschoff, J.1    Dietmaier, W.2    Luttges, J.3
  • 16
    • 0032794337 scopus 로고    scopus 로고
    • Medullary-type poorly differentiated adenocarcinoma of the large bowel: A distinct clinicopathologic entity characterized bymicrosatellite instability and improved survival
    • Lanza G, Gafa R, Matteuzzi M, Santini A. Medullary-type poorly differentiated adenocarcinoma of the large bowel: A distinct clinicopathologic entity characterized bymicrosatellite instability and improved survival. J Clin Oncol 1999; 17: 2429-2438.
    • (1999) J Clin Oncol , vol.17 , pp. 2429-2438
    • Lanza, G.1    Gafa, R.2    Matteuzzi, M.3    Santini, A.4
  • 17
    • 0035213535 scopus 로고    scopus 로고
    • Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability
    • Miyakura Y, Sugano K, Konishi F et al. Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology 2001; 121: 1300-1309.
    • (2001) Gastroenterology , vol.121 , pp. 1300-1309
    • Miyakura, Y.1    Sugano, K.2    Konishi, F.3
  • 18
    • 0036242782 scopus 로고    scopus 로고
    • CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability
    • Hawkins N, Norrie M, Cheong K et al. CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 2002; 122: 1376-1387.
    • (2002) Gastroenterology , vol.122 , pp. 1376-1387
    • Hawkins, N.1    Norrie, M.2    Cheong, K.3
  • 20
    • 0032401808 scopus 로고    scopus 로고
    • Aging and DNA methylation in colorectal mucosa and cancer
    • Ahuja N, Li Q, Mohan AL, Baylin SB, Issa JP. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res 1998; 58: 5489-5494.
    • (1998) Cancer Res , vol.58 , pp. 5489-5494
    • Ahuja, N.1    Li, Q.2    Mohan, A.L.3    Baylin, S.B.4    Issa, J.P.5
  • 21
    • 0035888252 scopus 로고    scopus 로고
    • Age-related hypermethylation of the hMLH1 promoter in gastric cancers
    • Nakajima T, Akiyama Y, Shiraishi J et al. Age-related hypermethylation of the hMLH1 promoter in gastric cancers. Int J Cancer 2001; 94: 208-211.
    • (2001) Int J Cancer , vol.94 , pp. 208-211
    • Nakajima, T.1    Akiyama, Y.2    Shiraishi, J.3
  • 22
    • 0037443773 scopus 로고    scopus 로고
    • Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age
    • Kakar S, Burgart LJ, Thibodeau SN et al. Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age. Cancer 2003; 97: 1421-1427.
    • (2003) Cancer , vol.97 , pp. 1421-1427
    • Kakar, S.1    Burgart, L.J.2    Thibodeau, S.N.3
  • 23
    • 33748939095 scopus 로고    scopus 로고
    • Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia
    • So K, Tamura G, Honda T et al. Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia. Cancer Sci 2006; 97: 1155-1158.
    • (2006) Cancer Sci , vol.97 , pp. 1155-1158
    • So, K.1    Tamura, G.2    Honda, T.3
  • 24
    • 4644262228 scopus 로고    scopus 로고
    • Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly
    • Arai T, Esaki Y, Sawabe M, Honma N, Nakamura K, Takubo K. Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly. Mod Pathol 2004; 17: 172-179.
    • (2004) Mod Pathol , vol.17 , pp. 172-179
    • Arai, T.1    Esaki, Y.2    Sawabe, M.3    Honma, N.4    Nakamura, K.5    Takubo, K.6
  • 25
    • 0033941821 scopus 로고    scopus 로고
    • Pathology of hereditary nonpolyposis colorectal cancer
    • Jass JR. Pathology of hereditary nonpolyposis colorectal cancer. Ann NY Acad Sci 2000; 910: 62-74.
    • (2000) Ann NY Acad Sci , vol.910 , pp. 62-74
    • Jass, J.R.1
  • 26
    • 0030814777 scopus 로고    scopus 로고
    • Microsatellite instability in sporadic mucinous colorectal carcinomas: Relationship to clinico-pathological variables
    • Messerini L, Vitelli F, De Vitis LR et al. Microsatellite instability in sporadic mucinous colorectal carcinomas: Relationship to clinico-pathological variables. J Pathol 1997; 182: 380-384.
    • (1997) J Pathol , vol.182 , pp. 380-384
    • Messerini, L.1    Vitelli, F.2    De Vitis, L.R.3
  • 27
    • 33847105603 scopus 로고    scopus 로고
    • Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: Comparison with medullary type poorly differentiated adenocarcinoma
    • Arai T, Kasahara I, Sawabe M et al. Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: Comparison with medullary type poorly differentiated adenocarcinoma. Pathol Int 2007; 57: 205-212.
    • (2007) Pathol Int , vol.57 , pp. 205-212
    • Arai, T.1    Kasahara, I.2    Sawabe, M.3
  • 28
    • 2642535288 scopus 로고    scopus 로고
    • Mucinous carcinoma of the colon: Correlation of loss of mismatch repair enzymes with clinicopathologic features and survival
    • Kakar S, Aksoy S, Burgart LJ, Smyrk TC. Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival. Mod Pathol 2004; 17: 696-700.
    • (2004) Mod Pathol , vol.17 , pp. 696-700
    • Kakar, S.1    Aksoy, S.2    Burgart, L.J.3    Smyrk, T.C.4
  • 29
    • 33748868177 scopus 로고    scopus 로고
    • Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma
    • Arai T, Sugai T, Kasahara I et al. Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma. Pathol Int 2006; 56: 597-603.
    • (2006) Pathol Int , vol.56 , pp. 597-603
    • Arai, T.1    Sugai, T.2    Kasahara, I.3
  • 30
    • 0034866370 scopus 로고    scopus 로고
    • The OGG1 gene encodes a repair enzyme for oxidatively damaged DNA and is involved in human carcinogenesis
    • Shinmura K, Yokota J. The OGG1 gene encodes a repair enzyme for oxidatively damaged DNA and is involved in human carcinogenesis. Antioxid Redox Signal 2001; 3: 597-609.
    • (2001) Antioxid Redox Signal , vol.3 , pp. 597-609
    • Shinmura, K.1    Yokota, J.2
  • 31
    • 0033552638 scopus 로고    scopus 로고
    • Twenty years of p53 research: Structural and functional aspects of the p53 protein
    • May P, May E. Twenty years of p53 research: Structural and functional aspects of the p53 protein. Oncogene 1999; 18: 7621-7636.
    • (1999) Oncogene , vol.18 , pp. 7621-7636
    • May, P.1    May, E.2
  • 32
    • 0032519766 scopus 로고    scopus 로고
    • Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans
    • Shen MR, Jones IM, Mohrenweiser H. Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res 1998; 58: 604-608.
    • (1998) Cancer Res , vol.58 , pp. 604-608
    • Shen, M.R.1    Jones, I.M.2    Mohrenweiser, H.3
  • 33
    • 0033599584 scopus 로고    scopus 로고
    • A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1
    • Ito E, Yanagisawa Y, Iwahashi Y et al. A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1. Biochem Biophys Res Commun 1999; 256: 488-494.
    • (1999) Biochem Biophys Res Commun , vol.256 , pp. 488-494
    • Ito, E.1    Yanagisawa, Y.2    Iwahashi, Y.3
  • 34
    • 33646147149 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha -308A/G polymorphism is associated with age at onset of Alzheimer's disease
    • Lio D, Annoni G, Licastro F et al. Tumor necrosis factor-alpha -308A/G polymorphism is associated with age at onset of Alzheimer's disease. Mech Ageing Dev 2006; 127: 567-571.
    • (2006) Mech Ageing Dev , vol.127 , pp. 567-571
    • Lio, D.1    Annoni, G.2    Licastro, F.3
  • 35
    • 33144460815 scopus 로고    scopus 로고
    • Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status
    • Menin C, Scaini MC, De Salvo GL et al. Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. J Natl Cancer Inst 2006; 98: 285-288.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 285-288
    • Menin, C.1    Scaini, M.C.2    De Salvo, G.L.3
  • 37
    • 12344273381 scopus 로고    scopus 로고
    • Variation in the human TP53 gene affects old age survival and cancer mortality
    • van Heemst D, Mooijaart SP, Beekman M et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol 2005; 40: 11-15.
    • (2005) Exp Gerontol , vol.40 , pp. 11-15
    • van Heemst, D.1    Mooijaart, S.P.2    Beekman, M.3
  • 38
    • 27744531188 scopus 로고    scopus 로고
    • Genetic polymorphisms in the base excision repair pathway and cancer risk: A HuGE review
    • Hung RJ, Hall J, Brennan P, Boffetta P. Genetic polymorphisms in the base excision repair pathway and cancer risk: A HuGE review. Am J Epidemiol 2005; 162: 925-942.
    • (2005) Am J Epidemiol , vol.162 , pp. 925-942
    • Hung, R.J.1    Hall, J.2    Brennan, P.3    Boffetta, P.4
  • 39
  • 40
    • 33646730157 scopus 로고    scopus 로고
    • Interaction of OGG1 Ser326Cys polymorphism with cigarette smoking in head and neck squamous cell carcinoma
    • Hashimoto T, Uchida K, Okayama N et al. Interaction of OGG1 Ser326Cys polymorphism with cigarette smoking in head and neck squamous cell carcinoma. Mol Carcinog 2006; 45: 344-348.
    • (2006) Mol Carcinog , vol.45 , pp. 344-348
    • Hashimoto, T.1    Uchida, K.2    Okayama, N.3
  • 41
  • 42
    • 0038494642 scopus 로고    scopus 로고
    • TP53 polymorphisms and lung cancer risk: A systematic review and meta-analysis
    • Matakidou A, Eisen T, Houlston RS. TP53 polymorphisms and lung cancer risk: A systematic review and meta-analysis. Mutagenesis 2003; 18: 377-385.
    • (2003) Mutagenesis , vol.18 , pp. 377-385
    • Matakidou, A.1    Eisen, T.2    Houlston, R.S.3
  • 44
    • 0037143095 scopus 로고    scopus 로고
    • p53 Codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis
    • Hiyama T, Tanaka S, Kitadai Y et al. p53 Codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis. Int J Cancer 2002; 100: 304-308.
    • (2002) Int J Cancer , vol.100 , pp. 304-308
    • Hiyama, T.1    Tanaka, S.2    Kitadai, Y.3
  • 45
    • 33748517404 scopus 로고    scopus 로고
    • p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer
    • Koushik A, Tranah GJ, Ma J et al. p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer. Int J Cancer 2006; 119: 1863-1868.
    • (2006) Int J Cancer , vol.119 , pp. 1863-1868
    • Koushik, A.1    Tranah, G.J.2    Ma, J.3
  • 46
    • 0037179547 scopus 로고    scopus 로고
    • P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck: A case-control study
    • Shen H, Zheng Y, Sturgis EM, Spitz MR, Wei Q. P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck: A case-control study. Cancer Lett 2002; 183: 123-130.
    • (2002) Cancer Lett , vol.183 , pp. 123-130
    • Shen, H.1    Zheng, Y.2    Sturgis, E.M.3    Spitz, M.R.4    Wei, Q.5
  • 47
    • 0642314312 scopus 로고    scopus 로고
    • P53 codon 72 polymorphism in breast cancer
    • Buyru N, Tigli H, Dalay N. P53 codon 72 polymorphism in breast cancer. Oncol Rep 2003; 10: 711-714.
    • (2003) Oncol Rep , vol.10 , pp. 711-714
    • Buyru, N.1    Tigli, H.2    Dalay, N.3
  • 49
    • 22244477048 scopus 로고    scopus 로고
    • XRCC1 polymorphisms and cancer risk: A meta-analysis of 38 case-control studies
    • Hu Z, Ma H, Chen F, Wei Q, Shen H. XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies. Cancer Epidemiol Biomarkers Prev 2005; 14: 1810-1818.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 1810-1818
    • Hu, Z.1    Ma, H.2    Chen, F.3    Wei, Q.4    Shen, H.5
  • 50
    • 33646241539 scopus 로고    scopus 로고
    • DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
    • Matullo G, Dunning AM, Guarrera S et al. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. Carcinogenesis 2006; 27: 997-1007.
    • (2006) Carcinogenesis , vol.27 , pp. 997-1007
    • Matullo, G.1    Dunning, A.M.2    Guarrera, S.3
  • 51
    • 33749036570 scopus 로고    scopus 로고
    • DNA-repair gene polymorphisms predict favorable clinical outcome among patients with advanced squamous cell carcinoma of the head and neck treated with cisplatin-based induction chemotherapy
    • Quintela-Fandino M, Hitt R, Medina PP et al. DNA-repair gene polymorphisms predict favorable clinical outcome among patients with advanced squamous cell carcinoma of the head and neck treated with cisplatin-based induction chemotherapy. J Clin Oncol 2006; 24: 4333-4339.
    • (2006) J Clin Oncol , vol.24 , pp. 4333-4339
    • Quintela-Fandino, M.1    Hitt, R.2    Medina, P.P.3
  • 52
    • 0035206506 scopus 로고    scopus 로고
    • Polymorphism of the p53 gene within the codon 72 in lung cancer patients
    • Biros E, Kalina I, Biros I et al. Polymorphism of the p53 gene within the codon 72 in lung cancer patients. Neoplasma 2001; 48: 407-411.
    • (2001) Neoplasma , vol.48 , pp. 407-411
    • Biros, E.1    Kalina, I.2    Biros, I.3
  • 53
    • 33644870366 scopus 로고    scopus 로고
    • Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    • Zienolddiny S, Campa D, Lind H et al. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis 2006; 27: 560-567.
    • (2006) Carcinogenesis , vol.27 , pp. 560-567
    • Zienolddiny, S.1    Campa, D.2    Lind, H.3
  • 54
    • 33750311904 scopus 로고    scopus 로고
    • Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: A meta-analysis
    • Kiyohara C, Takayama K, Nakanishi Y. Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis. Lung Cancer 2006; 54: 267-283.
    • (2006) Lung Cancer , vol.54 , pp. 267-283
    • Kiyohara, C.1    Takayama, K.2    Nakanishi, Y.3
  • 55
    • 4344701557 scopus 로고    scopus 로고
    • Developments of geriatric autopsy database and Internet-based database of Japanese single nucleotide polymorphisms for geriatric research (JG-SNP)
    • Sawabe M, Arai T, Kasahara I et al. Developments of geriatric autopsy database and Internet-based database of Japanese single nucleotide polymorphisms for geriatric research (JG-SNP). Mech Ageing Dev 2004; 125: 547-552.
    • (2004) , vol.125 , pp. 547-552
    • Sawabe, M.1    Arai, T.2    Kasahara, I.3
  • 56
    • 18844476564 scopus 로고    scopus 로고
    • Insertion/deletion polymorphism in the angiotensin-converting enzyme gene affects heart weight
    • Nakahara K, Matsushita S, Matsuoka H et al. Insertion/deletion polymorphism in the angiotensin-converting enzyme gene affects heart weight. Circulation 2000; 101: 148-151.
    • (2000) Circulation , vol.101 , pp. 148-151
    • Nakahara, K.1    Matsushita, S.2    Matsuoka, H.3
  • 57
    • 4344653188 scopus 로고    scopus 로고
    • Association between a promoter polymorphism of the paraoxonase PON1 gene and pathologically verified Parkinson's disease
    • Kazama H, Hosoi T, Nakahara K et al. Association between a promoter polymorphism of the paraoxonase PON1 gene and pathologically verified Parkinson's disease. Geriatr Gerontol Int 2002; 2: 91-96.
    • (2002) Geriatr Gerontol Int , vol.2 , pp. 91-96
    • Kazama, H.1    Hosoi, T.2    Nakahara, K.3
  • 58
    • 4344616023 scopus 로고    scopus 로고
    • Association of estrogen receptor alpha gene polymorphisms with neurofibrillary tangles
    • Kazama H, Ruberu NN, Murayama S et al. Association of estrogen receptor alpha gene polymorphisms with neurofibrillary tangles. Dement Geriatr Cogn Disord 2004; 18: 145-150.
    • (2004) Dement Geriatr Cogn Disord , vol.18 , pp. 145-150
    • Kazama, H.1    Ruberu, N.N.2    Murayama, S.3
  • 59
    • 20144367222 scopus 로고    scopus 로고
    • Aortic pulse wave velocity and the degree of atherosclerosis in the elderly: A pathological study based on 304 autopsy cases
    • Sawabe M, Takahashi R, Matsushita S et al. Aortic pulse wave velocity and the degree of atherosclerosis in the elderly: A pathological study based on 304 autopsy cases. Atherosclerosis 2005; 179: 345-351.
    • (2005) , vol.179 , pp. 345-351
    • Sawabe, M.1    Takahashi, R.2    Matsushita, S.3
  • 60
    • 33646393238 scopus 로고    scopus 로고
    • Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: A pathological study of 1074 consecutive autopsy cases
    • Sawabe M, Arai T, Kasahara I et al. Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: A pathological study of 1074 consecutive autopsy cases. Atherosclerosis 2006; 186: 374-379.
    • (2006) , vol.186 , pp. 374-379
    • Sawabe, M.1    Arai, T.2    Kasahara, I.3
  • 61
    • 34047104919 scopus 로고    scopus 로고
    • Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: A pathological study of 1503 consecutive autopsy cases
    • Oda K, Tanaka N, Arai T et al. Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases. Hum Mol Genet 2007; 16: 592-599.
    • (2007) Hum Mol Genet , vol.16 , pp. 592-599
    • Oda, K.1    Tanaka, N.2    Arai, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.