Use of growth hormone secretagogues to prevent or treat the effects of aging: Not yet ready for prime time

Annals of Internal Medicine

Volumn 149, Issue 9, 2008, Pages 677-679

  Blackman, Marc R ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; GHRELIN; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE; IBUTAMOREN; PLACEBO; SOMATOMEDIN; SOMATOMEDIN C; TESTOSTERONE; HUMAN GROWTH HORMONE; INDOLE DERIVATIVE; SPIRO COMPOUND;

AGE DISTRIBUTION; AGING; ANDROGEN DEFICIENCY; ARTHRALGIA; BODY COMPOSITION; BONE MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL TRIAL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DYSLIPIDEMIA; EDITORIAL; ESTROGEN DEFICIENCY; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONE SUBSTITUTION; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; MENOPAUSE; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE STRENGTH; MYALGIA; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OSTEOPENIA; PERIPHERAL EDEMA; PRIORITY JOURNAL; QUALITY OF LIFE; SIDE EFFECT; SKELETAL MUSCLE; ADIPOSE TISSUE; NOTE; PHYSIOLOGY; SECRETION;

ADIPOSE TISSUE; AGING; BODY COMPOSITION; HUMAN GROWTH HORMONE; HUMANS; INDOLES; SPIRO COMPOUNDS;

EID: 55749090771     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-149-9-200811040-00010     Document Type: Editorial

References (20)

1. Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocr Rev. 1993;14:20-39. [PMID: 8491152]
2. Matsumoto AM. Andropause: clinical implications of the decline in serum testosterone levels with aging in men. J Gerontol A Biol Sci Med Sci. 2002;57: M76-99. [PMID: 11818427]
3. Roy TA, Blackman MR, Harman SM, Tobin JD, Schrager M, Metter EJ. Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men. Am J Physiol Endocrinol Metab. 2002;283:E284-94. [PMID: 12110533]
4. Baumgartner RN, Heymsfield SB, Roche AF, Bernardino M. Abdominal composition quantified by computed tomography. Am J Clin Nutr. 1988;48: 936-45. [PMID: 3421203]
5. Walker SP, Rimm EB, Ascherio A, Kawachi I, Stampfer MJ, Willett WC. Body size and fat distribution as predictors of stroke among US men. Am J Epidemiol. 1996;144:1143-50. [PMID: 8956626]
6. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49:M85-94. [PMID: 8126356]
7. Carroll PV, Christ ER, Bengtsson BA, Carlsson L, Christiansen JS, Clemmons D, et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab. 1998;83:382-95. [PMID: 9467546]
8. Liu H, Bravata DM, Olkin I, Nayak S, Roberts B, Garber AM, et al. Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med. 2007;146:104-15. [PMID: 17227934]
9. Corpas E, Harman SM, Piñeyro MA, Roberson R, Blackman MR. Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men. J Clin Endocrinol Metab. 1992;75:530-5. [PMID: 1379256]
10. Copinschi G, Van Onderbergen A, L'Hermite-Balériaux M, Mendel CM, Caufriez A, Leproult R, et al. Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men. J Clin Endocrinol Metab. 1996;81:2776-82. [PMID: 8768828]
11. Chapman IM, Hartman ML, Pezzoli SS, Thorner MO. Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692, 429, in older adults - a clinical research center study. J Clin Endocrinol Metab. 1996;81:2874-80. [PMID: 8768844]
12. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656-60. [PMID: 10604470]
13. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273:974-7. [PMID: 8688086]
14. Smith RG, Jiang H, Sun Y. Developments in ghrelin biology and potential clinical relevance. Trends Endocrinol Metab. 2005;16:436-42. [PMID: 16213742]
15. Svensson J, Lönn L, Jansson JO, Murphy G, Wyss D, Krupa D, et al. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. J Clin Endocrinol Metab. 1998;83:362-9. [PMID: 9467542]
16. Veldhuis JD, Patrie JM, Frick K, Weltman JY, Weltman AL. Administration of recombinant human GHRH-1, 44-amide for 3 months reduces abdominal visceral fat mass and increases physical performance measures in postmenopausal women. Eur J Endocrinol. 2005;153:669-77. [PMID: 16260425]
17. Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE Jr, Clasey JL, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults. A randomized trial. Ann Intern Med. 2008;149:601-11.
18. Burman P, Johansson AG, Siegbahn A, Vessby B, Karlsson FA. Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women. J Clin Endocrinol Metab. 1997;82:550-5. [PMID: 9024252]
19. White H, Merriam GR, Petrie C, Landschulz W, MacLean D, Fryburg D, et al. Effects of an oral growth hormone secretagogue in pre-frail older adults: an exploratory study. Paper presented at the American Geriatrics Society Annual Meeting, Orlando, Florida, 11-15 May 2005.
20. Merriam GR, Blackman MR, Hoffman AR, Salvatori R, Wei J, White HK, et al. Effects of chronic treatment with an oral growth hormone (GH) secretagogue on nocturnal GH secretion and IGF-I in older men and women. Paper presented at the 6th International Congress of Neuroendocrinology, Pittsburgh, Pennsylvania, 19-22 June 2006.