Efficient synthesis and biological evaluation of two modafinil analogues

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 23, 2008, Pages 9904-9910

  De Risi, Carmela ^a   Ferraro, Luca ^b   Pollini, Gian P ^a   Tanganelli, Sergio ^b   Valente, Filippo ^a   Veronese, Augusto C ^a  

^a Dipartimento di Scienze Farmaceutiche   (Italy)

^b Dipartimento di Medicina Clinica e Sperimentale   (Italy)

Author keywords

3H 5 HT efflux; Bioisosters; Modafinil; Rat cerebral cortex slices

Indexed keywords

3 OXO 4,4 DIPHENYL N (PROPAN 2 YL) BUTANAMIDE; 3 OXO 4,4 DIPHENYLBUTANAMIDE; 5 (1 HYDROXY 2,2 DIPHENYLETHYLIDENE) 2,2 DIMETHYL 1,3 DIOXANE 4,6 DIONE; CARBONYL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; DIPHENYLACETYL CHLORIDE; ETHYL 3 OXOX 4,4 DIPHENYLBUTANOATE; MODAFINIL; N O BIS (TERT BUTOXYCARBONYL) N HYDROXY 3 OXOX 4,4 DIPHENYLBUTANAMIDE; SEROTONIN; SULFOXIDE; TERT BUTYL (3 OXO 4,4 DIPHENYLBUTANOYL)CARBAMATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BRAIN CORTEX; CONTROLLED STUDY; DRUG SYNTHESIS; EVOKED RESPONSE; MALE; NONHUMAN; RAT; SEROTONIN UPTAKE; SPRAGUE DAWLEY RAT;

ANIMALS; BENZHYDRYL COMPOUNDS; CENTRAL NERVOUS SYSTEM STIMULANTS; DATA INTERPRETATION, STATISTICAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; STEREOISOMERISM;

RATTUS;

EID: 55749083043     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.027     Document Type: Article

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