Distribution of cells expressing human renin-promoter activity in the brain of a transgenic mouse

Brain Research

Volumn 1243, Issue , 2008, Pages 78-85

  Allen, A M ^a   O'Callaghan, E L ^a   Hazelwood, L ^a   Germain, S ^b   Castrop, H ^c,d   Schnermann, J ^c   Bassi, J K ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b l'alimentation et l'Environnement   (France)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Brain development; Brain renin angiotensin system; Neurochemistry

Indexed keywords

BETA GALACTOSIDASE; CRE RECOMBINASE; NEURON SPECIFIC NUCLEAR PROTEIN; RENIN;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CEREBELLUM; CONTROLLED STUDY; FOREBRAIN; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MEDULLA OBLONGATA; MESENCEPHALON; MOTOR CORTEX; MOUSE; NEUROCHEMISTRY; NONHUMAN; PARABRACHIAL NUCLEUS; PERIAQUEDUCTAL GRAY MATTER; PONS; PRIORITY JOURNAL; PROMOTER REGION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENIC MOUSE;

ANIMALS; BETA-GALACTOSIDASE; BRAIN; BRAIN MAPPING; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LAC OPERON; MICE; MICE, TRANSGENIC; MOLECULAR BIOLOGY; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; RECEPTORS, ANGIOTENSIN; RENIN; RENIN-ANGIOTENSIN SYSTEM;

MUS MUSCULUS;

EID: 55649122980     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.09.046     Document Type: Article

References (46)

1. Allen A.M., Chai S.Y., Clevers J., McKinley M.J., Paxinos G., and Mendelsohn F.A. Localization and characterization of angiotensin II receptor binding and angiotensin converting enzyme in the human medulla oblongata. J. Comp. Neurol. 269 (1988) 249-264
2. Allen A.M., Paxinos G., Song K.F., and Mendelsohn F.A.O. Localization of angiotensin receptor binding sites in the rat brain. In: Bjorklund A., Hokfelt T., and Kuhar M.J. (Eds). Neuropeptide receptors in the CNS Handbook of Chemical Neuroanatomy Vol. 11 (1992), Elsevier, Amsterdam 1-38
3. Baubonis W., and Sauer B. Genomic targeting with purified Cre recombinase. Nucleic Acids Res. 21 (1993) 2025-2029
4. Castrop H., Oppermann M., Weiss Y., Huang Y., Mizel D., Lu H., Germain S., Schweda F., Theilig F., Bachmann S., Briggs J., Kurtz A., and Schnermann J. Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene. Physiol. Genomics. 25 (2006) 277-285
5. Castrop H., Oppermann M., Mizel D., Huang Y., Faulhaber-Walter R., Weiss Y., Weinstein L.S., Chen M., Germain S., Lu H., Ragland D., Schimel D.M., and Schnermann J. Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter-Cre transgene. Cell Tissue Res. 330 (2007) 487-501
6. Chai S.Y., Mendelsohn F.A., and Paxinos G. Angiotensin converting enzyme in rat brain visualized by quantitative in vitro autoradiography. Neuroscience 20 (1987) 615-627
7. Chen L., Kim S.M., Oppermann M., Faulhaber-Walter R., Huang Y., Mizel D., Chen M., Lopez M.L., Weinstein L.S., Gomez R.A., Briggs J.P., and Schnermann J. Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsalpha in juxtaglomerular cells. Am. J. Physiol. Renal. Physiol. 292 (2007) F27-F37
8. Chen X., Macica C.M., Dreyer B.E., Hammond V.E., Hens J.R., Philbrick W.M., and Broadus A.E. Initial characterization of PTH-related protein gene-driven lacZ expression in the mouse. J. Bone Miner. Res. 21 (2006) 113-123
9. Clausmeyer S., Sturzebecher R., and Peters J. An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria. Circ. Res. 84 (1999) 337-344
10. Dzau V.J., Brenner A., and Emmett N.L. Evidence for renin in rat brain: differentiation from other reninlike enzymes. Am. J. Physiol. 242 (1982) E292-E297
11. Dzau V.J., Ingelfinger J., Pratt R.E., and Ellison K.E. Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains. Hypertension 8 (1986) 544-548
12. Ekker M., Tronik D., and Rougeon F. Extra-renal transcription of the renin genes in multiple tissues of mice and rats. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 5155-5158
13. Fuchs S., Philippe J., Germain S., Mathieu F., Jeunemaitre X., Corvol P., and Pinet F. Functionality of two new polymorphisms in the human renin gene enhancer region. J. Hypertens. 20 (2002) 2391-2398
14. Hauser W., Johren O., and Saavedra J.M. Characterization and distribution of angiotensin II receptor subtypes in the mouse brain. Eur. J. Pharmacol. 348 (1998) 101-114
15. Inagami T., Clemens D.L., Celio M.R., Brown A., Sandru L., Herschkowitz N., Hoffman L.H., and Kasselberg A.G. Immunohistochemical localization of renin in mouse brain. Neurosci. Lett. 18 (1980) 91-98
16. Itani H.A., Liu X., Pratt J.H., and Sigmund C.D. Functional characterization of polymorphisms in the kidney enhancer of the human renin gene. Endocrinology 148 (2007) 1424-1430
17. Jones C.A., Hurley M.I., Black T.A., Kane C.M., Pan L., Pruitt S.C., and Gross K.W. Expression of a renin/GFP transgene in mouse embryonic, extra-embryonic, and adult tissues. Physiol. Genomics. 4 (2000) 75-81
18. Karamyan V.T., and Speth R.C. Enzymatic pathways of the brain renin-angiotensin system: unsolved problems and continuing challenges. Regul. Pept. 143 (2007) 15-27
19. Karamyan V.T., and Speth R.C. Identification of a novel non-AT1, non-AT2 angiotensin binding site in the rat brain. Brain Res. 1143 (2007) 83-91
20. Lavoie J.L., Cassell M.D., Gross K.W., and Sigmund C.D. Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. Physiol. Genomics. 16 (2004) 240-246
21. Lavoie J.L., Cassell M.D., Gross K.W., and Sigmund C.D. Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model. Hypertension 43 (2004) 1116-1119
22. Lavoie J.L., Liu X., Bianco R.A., Beltz T.G., Johnson A.K., and Sigmund C.D. Evidence supporting a functional role for intracellular renin in the brain. Hypertension 47 (2006) 461-466
23. Lee-Kirsch M.A., Gaudet F., Cardoso M.C., and Lindpaintner K. Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing. Circ. Res. 84 (1999) 240-246
24. Lein E.S., Hawrylycz M.J., Ao N., Ayres M., Bensinger A., Bernard A., Boe A.F., Boguski M.S., Brockway K.S., Byrnes E.J., Chen L., Chen T.M., Chin M.C., Chong J., Crook B.E., Czaplinska A., Dang C.N., Datta S., Dee N.R., Desaki A.L., Desta T., Diep E., Dolbeare T.A., Donelan M.J., Dong H.W., Dougherty J.G., Duncan B.J., Ebbert A.J., Eichele G., Estin L.K., Faber C., Facer B.A., Fields R., Fischer S.R., Fliss T.P., Frensley C., Gates S.N., Glattfelder K.J., Halverson K.R., Hart M.R., Hohmann J.G., Howell M.P., Jeung D.P., Johnson R.A., Karr P.T., Kawal R., Kidney J.M., Knapik R.H., Kuan C.L., Lake J.H., Laramee A.R., Larsen K.D., Lau C., Lemon T.A., Liang A.J., Liu Y., Luong L.T., Michaels J., Morgan J.J., Morgan R.J., Mortrud M.T., Mosqueda N.F., Ng L.L., Ng R., Orta G.J., Overly C.C., Pak T.H., Parry S.E., Pathak S.D., Pearson O.C., Puchalski R.B., Riley Z.L., Rockett H.R., Rowland S.A., Royall J.J., Ruiz M.J., Sarno N.R., Schaffnit K., Shapovalova N.V., Sivisay T., Slaughterbeck C.R., Smith S.C., Smith K.A., Smith B.I., Sodt A.J., Stewart N.N., Stumpf K.R., Sunkin S.M., Sutram M., Tam A., Teemer C.D., Thaller C., Thompson C.L., Varnam L.R., Visel A., Whitlock R.M., Wohnoutka P.E., Wolkey C.K., Wong V.Y., Wood M., Yaylaoglu M.B., Young R.C., Youngstrom B.L., Yuan X.F., Zhang B., Zwingman T.A., and Jones A.R. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445 (2007) 168-176
25. Lenkei Z., Palkovits M., Corvol P., and Llorens-Cortes C. Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review. Front Neuroendocrinol. 18 (1997) 383-439
26. Millan M.A., Jacobowitz D.M., Aguilera G., and Catt K.J. Differential distribution of AT1 and AT2 angiotensin II receptor subtypes in the rat brain during development. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 11440-11444
27. Moffett R.B. Angiotensinogen in cerebrospinal fluid corresponds chromatographically to the gamma-form of plasma angiotensinogen. J. Neurochem. 49 (1987) 841-845
28. Moffett R.B., Bumpus F.M., and Husain A. Cellular organization of the brain renin-angiotensin system. Life Sci. 41 (1987) 1867-1879
29. Morimoto S., Cassell M.D., and Sigmund C.D. The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circ. Res. 90 (2002) 80-86
30. Nguyen G., Delarue F., Burckle C., Bouzhir L., Giller T., and Sraer J.D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. 109 (2002) 1417-1427
31. Pan L., and Gross K.W. Transcriptional regulation of renin: an update. Hypertension 45 (2005) 3-8
32. Paul M., Poyan Mehr A., and Kreutz R. Physiology of local renin-angiotensin systems. Physiol. Rev. 86 (2006) 747-803
33. Paxinos G., and Franklin K.B.J. The Mouse Brain in Stereotaxic Coordinates (2004), Elsevier Academic Press, California
34. Sakai K., and Sigmund C.D. Molecular evidence of tissue renin-angiotensin systems: a focus on the brain. Curr. Hypertens. Rep. 7 (2005) 135-140
35. Sequeira Lopez M.L., Pentz E.S., Nomasa T., Smithies O., and Gomez R.A. Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Dev. Cell. 6 (2004) 719-728
36. Shan Z., Cuadra A.E., Sumners C., and Raizada M.K. Characterization of a functional (Pro)renin receptor in brain neurons. Exp. Physiol. 93 (2008) 701-708
37. Sigmund C.D., Jones C.A., Mullins J.J., Kim U., and Gross K.W. Expression of murine renin genes in subcutaneous connective tissue. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 7993-7997
38. Sinn P.L., and Sigmund C.D. Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. Physiol. Genomics. 3 (2000) 25-31
39. Slater E.E., Defendini R., and Zimmerman E.A. Wide distribution of immunoreactive renin in nerve cells of human brain. Proc. Natl. Acad. Sci. U. S. A. 77 (1980) 5458-5460
40. Song K., Allen A.M., Paxinos G., and Mendelsohn F.A. Mapping of angiotensin II receptor subtype heterogeneity in rat brain. J. Comp. Neurol. 316 (1992) 467-484
41. Sood P.P., Panigel M., and Wegmann R. The existence of renin-angiotensinogen system in the rat fetal brain: I. Immunocytochemical localization of renin-like activity at the 19th day of gestation. Cell. Mol. Biol. 33 (1987) 675-680
42. Steckelings U.M., Wollschlager T., Peters J., Henz B.M., Hermes B., and Artuc M. Human skin: source of and target organ for angiotensin II. Exp. Dermatol. 13 (2004) 148-154
43. Steege A., Fahling M., Paliege A., Bondke A., Kirschner K.M., Martinka P., Kaps C., Patzak A., Persson P.B., Thiele B.J., Scholz H., and Mrowka R. Wilms' tumor protein (-KTS) modulates renin gene transcription. Kidney Int. 74 (2008) 458-466
44. Stornetta R.L., Hawelu-Johnson C.L., Guyenet P.G., and Lynch K.R. Astrocytes synthesize angiotensinogen in brain. Science 242 (1988) 1444-1446
45. Thomas W.G., and Sernia C. Immunocytochemical localization of angiotensinogen in the rat brain. Neuroscience 25 (1988) 319-341
46. Todorov V.T., Desch M., Schubert T., and Kurtz A. The Pal3 promoter sequence is critical for the regulation of human renin gene transcription by PPAR{gamma}. Endocrinology 149 (2008) 4647-4657