(iv) Osteoporosis treatments and their effect on fracture healing

Current Orthopaedics

Volumn 22, Issue 5, 2008, Pages 336-340

  Johnson Lynn, Sarah E ^a   Francis, Roger ^a   McCaskie, Andrew ^a  

^a FREEMAN HOSPITAL   (United Kingdom)

Author keywords

Fracture healing; Osteoporosis; Treatment

Indexed keywords

ALENDRONIC ACID; ANDROGEN; BAZEDOXIFENE; BISPHOSPHONIC ACID DERIVATIVE; CALCITONIN; CALCIUM; CALCIUM SENSING RECEPTOR; CATHEPSIN K INHIBITOR; DENOSUMAB; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBANDRONIC ACID; INCADRONIC ACID; LITHIUM; PAMIDRONIC ACID; PARATHYROID HORMONE[1-34]; PLATELET DERIVED GROWTH FACTOR; SCLEROSTIN; SIMVASTATIN; STRONTIUM RANELATE; VITAMIN D; ZOLEDRONIC ACID;

ARTICLE; BONE DENSITY; BONE MASS; BONE REGENERATION; CALLUS; DRUG EFFECT; DRUG MEGADOSE; FEMUR FRACTURE; FEMUR OSTEOTOMY; FRACTURE HEALING; HUMAN; LOW DRUG DOSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; RISK FACTOR; SINGLE DRUG DOSE; TIBIA FRACTURE; TIBIA OSTEOTOMY; UNSPECIFIED SIDE EFFECT; VITAMIN SUPPLEMENTATION;

EID: 55649121159     PISSN: 02680890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cuor.2008.10.006     Document Type: Article

References (29)

1. Augat P., Simon U., Liedert A., and Claes L. Mechanics and mechano-biology of fracture healing in normal and osteoporotic bone. Osteoporos Int 16 (2005) S36-S43
2. Giannoudis P., Tzioupis C., Almalki T., and Buckley R. Fracture healing in osteoporotic fractures: is it really different?. Injury 38S1 (2007) S90-S99
3. Suda T., Takahashi N., Udagawa N., Jimi E., Gillespie M., and Martin T. Modulation of osteoclast differentiation and function by the new members of the tumour necrosis factor receptor and ligand families. Endocr Rev 20 (1999) 345-357
4. D'ippolito G., Schiller P., Ricordi C., Roos B., and Howard G. Age-Related Osteogenic Potential of Mesenchymal Stromal Stem Cells from Human Vertebral Bone Marrow. J Bone Miner Res 14 (1999) 1115-1122
5. Yingjie H., Ge Z., Yisheng W., et al. Changes of Microstructure and Mineralized tissue in the Middle and Late Phase of Osteoporotic Fracture Healing in Rats. Bone 41 (2007) 631-638
6. McCann R., Colleary G., Geddis C., et al. Effect of osteoporosis on bone mineral density and fracture repair in a rat femoral fracture model. J Orthop Res (March 2008) 384-393
7. Peter C., Cook W., Nunamaker D., Provost M., Seedor J., and Rodan G. Effect of Alendronate on Fracture Healing and Bone Remodelling in Dogs. J Orthop Res 14 1 (January 1996) 74-79
8. Goodship A., Walker P., McNally D., Chambers T., and Green J. Use of a bisphosphonate (pamidronate) to modulate fracture repair in ovine bone. Ann Oncol 5 Suppl. 7 (1994) S53-S55
9. Li C., Mori S., Li J., et al. Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats. J Bone Miner Res 16 3 (2001) 429-436
10. Li J., Mori S., Kaji Y., Mashiba T., Kawanishi J., and Norimatsu H. Effect of Bisphosphonate (Incadronate) on Fracture Healing of Long Bones in Rats. J Bone Miner Res 14 6 (1999) 969-979
11. Amanat N., McDonald M., Godfrey C., Bilston l., and Little D. Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. J Bone Miner Res 22 6 (2007) 867-876
12. Bauss F., Schenk R., Hort S., Muller-Beckmann B., and Sponer G. New model for simulation of fracture repair in full-grown beagle dogs: Model characterization and results from a long-term study with ibandronate. J Pharmacol Toxicol Methods 50 (2004) 25-34
13. Yang K., Won J., Yoon H., Ryu J., Choo K., and Kim J. High concentrations of pamidronate in bone weaken the mechanical properties of intact femora in a rat model. Yonsei Med J 48 4 (2007) 653-658
14. Odvina C., Zerwekh J., Rao D., Maalouf N., Gottschalk F., and Pak C. Severely suppressed bone turnover: A potential complication of alendronate therapy. J Clin Endocrinol Metab 90 3 (2005) 1294-1301
15. van der Poest C., Patka P., Vandormael K., Haarman H., and Lips P. The Effect of Alendronate on Bone Mass after Distal Forearm Fracture. J Bone Miner Res 15 3 (2000) 586-593
16. Norman A., Okamura W., Bishop J., and Henry H. Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3. Mol Cell Endocrinol 197 1-2 (2002) 1-13
17. Doetsch A., Faber J., Lynnerup N., Watjen I., Bliddal H., and Danneskiold-Samsoe. The Effect of Calcium and Vitamin D3 Supplementation on the Healing of the Proximal Humerus Fracture: A Randomized Placebo-Controlled Study. Calcif Tissue Int 75 (2004) 183-188
18. Li X., Luo X., Yu N., and Zeng B. Effects of salmon calcitonin on fracture healing in ovariectomized rats. Saudi Med J 28 1 (2007) 60-64
19. Huusko T., Karppi P., Kautiainen H., Suominen H., Avrikainen V., and Sulkava R. Randomized, Double-Blind, Clinically Controlled trial of Intranasal Calitonin Treatment in Patients with Hip Fracture. Calcif Tissue Int 71 (2002) 478-484
20. Cebesoy O., Tutar E., Kose K., Baltaci Y., and Bagci C. Effect of strontium ranelate on fracture healing in rat tibia. Joint Bone Spine 74 6 (2007) 1778-7254
21. Chalidis B., Tzioupis C., Tsiridis E., and Giannoudis P. Enhancement of fracture healing with parathyroid hormone: preclinical studies and potential clinical applications. Expert Opin Investig Drugs 16 4 (2007) 441-449
22. Skripitz R., Andreassen T., and Aspenberg P. Strong effect of PTH (1-34) on regenerating bone. A time sequence study in rats. Acta Orthop Scand 71 6 (2000) 619-624
23. Andreassen T., Ejersted C., and Oxlund H. Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures. J Bone Miner Res 14 6 (1999) 960-968
24. Andreassen T., Fledelius C., Ejersted C., and Oxlund H. Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone. Acta Orthop Scand 72 3 (2001) 304-307
25. Gardner M., van der Meaulen M., Carson J., et al. Role of parathyroid hormone in the mechanosensitivity of fracture healing. J Orthop Res (November 2007) 1474-1480
26. Wang J., Xu S., Yang D., and Lv R. Locally applied simvastatin promotes fracture healing in ovariectomized rat. Osteoporos Int 18 (2007) 1641-1650
27. Chen Y., Whetstone H., Lin A., et al. Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. PLoS Medicine 4 7 (2007) 249
28. Hollinger J., Onikepe A., MacKrell J., et al. Accelerated fracture healing in the geriatric, osteoprotic rat with recombinant human platelet-derived growth factor-bb and an injectable beta-tricalcium phosphate/ collagen matrix. J Orthop Res (January 2008) 83-90
29. Nash T.J., Howlett C.R., Martin C., Steele J., Johnson K.A., and Hicklin D.J. Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 15 2 (1994) 203-208