Randomized, double-blind, clinically controlled trial of intranasal calcitonin treatment in patients with hip fracture

Calcified Tissue International

Volumn 71, Issue 6, 2002, Pages 478-484

  Huusko, T M ^a   Karppi, P ^b   Kautiainen, H ^c   Suominen, H ^d   Avikainen, V ^b   Sulkava, R ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b JYVÄSKYLÄ CENTRAL HOSPITAL   (Finland)

^c RHEUMATISM FOUNDATION HOSPITAL   (Finland)

^d UNIVERSITY OF JYVÄSKYLÄ   (Finland)

Author keywords

Bone mineral density; Calcitonin; Fracture fusion; Hip fracture; Pain; Rehabilitation

Indexed keywords

PLACEBO; SALCATONIN; CALCITONIN;

AGED; ARTICLE; BONE MINERAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DOUBLE BLIND PROCEDURE; FEMALE; FLUSHING; FOLLOW UP; FRACTURE HEALING; HEADACHE; HIP FRACTURE; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; OSTEOLYSIS; OSTEOSYNTHESIS; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SKIN IRRITATION; TREATMENT OUTCOME; VISUAL ANALOG SCALE; BONE DENSITY; DRUG EFFECT; INTRANASAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS;

ACTIVITIES OF DAILY LIVING; ADMINISTRATION, INTRANASAL; AGED; AGED, 80 AND OVER; BONE DENSITY; BONE RESORPTION; CALCITONIN; DOUBLE-BLIND METHOD; FEMALE; FRACTURE FIXATION, INTERNAL; FRACTURE HEALING; HIP FRACTURES; HUMANS; LENGTH OF STAY; MALE; OSTEOPOROSIS, POSTMENOPAUSAL; PAIN; PAIN MEASUREMENT;

EID: 0037795672     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-001-2111-x     Document Type: Article

References (19)

1. Huusko T, Karppi P, Avikainen V, Kautiainen H, Sulkava R (1999) Significant changes in the surgical methods and length of hospital stay of hip fracture patients occurring over 10 years in Central Finland. Ann Chir Gynaecol 88:55-60
2. Hannan MT, Felson DT, Anderson JJ (1992) Bone mineral density in elderly men and women: results from the Framingham osteoporosis study. J Bone Miner Res 7:547-753
3. Lyritis GP, Paspati I, Karachalios T, Ioakimidis D, Skarantavos G, Lyritis P (1997) Pain relief from nasal salmon calcitonin in osteoporotic vertebral crush fractures. A double-blind, placebo-controlled clinical study. Acta Orthop Scand 68(Suppl)275:112-114
4. Lyritis GP, Tsakalos N, Magiasis B, Karachalios T, Yiatzides A, Tsekoura M (1991) Analgesic effect of salmon calcitonin in osteoporotic vertebral fractures: a double-blind placebo-controlled clinical study. Calcif Tissue Int 49:369-372
5. Darakchiev BJ, Bulas RV, Dunsker SB (2000) Use of calcitonin for the treatment of an odontoid fracture. Case report. J Neurosurg 93(Suppl)1:157-160
6. Huusko T, Karppi P, Avikainen V, Kautiainen H, Sulkava R (2000) Randomised, clinically controlled trial of intensive geriatric rehabilitation in patients with hip fracture: subgroup analysis of patients with dementia. BMJ 321:1107-1111
7. Garden RS (1961) Low angle fixation in fractures of the femoral neck. J Bone Joint Surg 43:647
8. Katz S, Downs TD, Cash HR, Grotz RC (1970) Progress in the development of the index of ADL. Gerontologist 1:20-30
9. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW (1963) Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA 185:914-919
10. Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 179-186
11. Folstein MF, Folstein SE, McHugh PR (1975) Mini-Mental State: a practical method for grading the cognitive stage of patients for the clinician. J Psychiatr Res 12:189-198
12. Suominen H, Heikkinen E, Vainio P, Lahtinen T (1984) Mineral density of calcaneus in men at different ages: a population-based study with special reference to life-style factors. Age Aging 13:273-281
13. Cheng S, Suominen H, Era P, Heikkinen P (1994) Bone density of the calcaneus and fractures in 75- and 80-year-old men and women. Osteoporosis Int 4:48-54
14. Cheng S, Suominen H, Sakari-Rantala R, Laukkanen P, Avikainen V, Heikkinen E (1997) Calcaneal bone mineral density predicts fracture occurrence: a five-year follow-up study in elderly people. J Bone Miner Res 12:1075-1082
15. Alho A, Benterud JG, Ronningen H, Hoiseth A (1991) Radiographic prediction of early failure in femoral neck fracture. Acta Orthop Scand 62:422-426
16. Kaloudis I, Karachalios T, Roidis NT, Bargiotas K, Ioannidis GV, Galanos AA, et al. (1998) The effect of 200 IU calcitonin administered daily on biochemical bone markers and bone density in patients with acute hip fracture. Osteoporosis Int 8(Suppl)3:112
17. Kanis JA, Johnell O, Gullberg B, Allander E, Dilsen G, Gennari C, et al. (1992) Evidence for efficacy of drugs affecting bone metabolism in preventing hip fractures. BMJ 305:1124-1128
18. Chesnut C, Silverman SL, Gimona A, Andriano K, Genant H, Richardson P, et al. (2000) Prevent recurrence of osteoporotic fractures. A multicentered, double-blind, randomized, 5-year study to investigate the efficacy of salmon calcitonin nasal spray in the prevention of osteoporotic vertebral fractures. Am J Med 109:267-276
19. Overgaard K, Hansen MA, Jensen SB, Christiansen C (1992) Effect of calcitonin given intranasally on bone mass and fracture rates in established osteoporosis: a dose-response study. BMJ 305(4):556-561