The application of conventional cytogenetics, FISH, and RT-PCR to detect genetic changes in 70 children with ALL

Annals of Hematology

Volumn 87, Issue 12, 2008, Pages 991-1002

  Soszynska, Krystyna ^a   Mucha, Barbara ^a   Debski, Robert ^a   Skonieczka, Katarzyna ^a   Duszenko, Ewa ^b   Koltan, Andrzej ^a   Wysocki, Mariusz ^a   Haus, Olga ^a,b  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Acute lymphoblastic leukemia; Chromosome aberrations; FISH; Prognosis; RT PCR

Indexed keywords

BCR ABL PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR PBX1; TRANSCRIPTION FACTOR RUNX1;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; BONE MARROW CELL; CHILD; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME STRUCTURE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYTOGENETICS; DIPLOIDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE REARRANGEMENT; GENETIC CORRELATION; HUMAN; HUMAN CELL; INFANT; KARYOTYPING; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; COHORT STUDIES; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; GENES, ABL; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; KAPLAN-MEIERS ESTIMATE; MALE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 55649114650     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-008-0540-6     Document Type: Article

References (29)

1. Arico M, Valsecchi MG, Camitta B, Schrappe M (2000) Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia. N Engl J Med 342:998-1007 doi: 10.1056/NEJM200004063421402
2. Campana D, Behm GB (2000) Immunophenotyping of leukemia. J Immunol Methods 243:59-75 doi: 10.1016/S0022-1759(00)00228-3
3. Carroll WL, Bhojwani D, Min DJ, Raetz E, Relling M, Davies S et al (2003) Pediatric acute lymphoblastic leukemia. Hematology 102-130 doi: 10.1182/asheducation-2003.1.102
4. Cimino G, Elia L, Rapanotti MC, Sprovieri T, Mancini M, Cuneo A et al (2000) A prospective study of residual disease monitoring of the ALL/AF4 transcript in patients with t(4;11) acute lymphoblastic leukemia. Blood 95:96-101
5. Douet-Guilbert N, Morel F, Le Bris M-J, Herry A, Le Calvez G, Marion V et al (2004) Cytogenetic studies in T-cell acute lymphoblastic leukemia. Leuk Lymphoma 45:287-290 doi: 10.1080/10428190310001603911
6. Ford A, Fasching K, Panzer-Grumayer ER, Koening M, Haas OA, Greaves MF (2001) Origins of late relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes. Blood 98:558-564 doi: 10.1182/blood.V98.3.558
7. Forestier E, Johansson B, Gustafsson G, Borgström G, Kerndrup G, Johannsson J, Heim S (2000) Prognostic impact of karyotypic findings in childhood acute lymphoblastic leukemia: A Nordic series comparing two treatment periods. Br J Haematol 110:147-153 doi: 10.1046/ j.1365-2141.2000.02153.x
8. Friedmann AM, Weinstein HJ (2000) The role of prognostic features in the treatment of childhood acute lymphoblastic leukemia. Oncologist 5:321-328 doi: 10.1634/theoncologist.5-4-321
9. Harrison CJ (2001) Detection and significance of chromosomal abnormalities in childhood acute lymphoblastic leukemia. Blood Rev 15:49-59 doi: 10.1054/blre.2001.0150
10. Heerema NA, Nachman JB, Sather HN, Sensel MG, Lee MK, Hutchinson R et al (1999) Hypodiploidy with less than 45 chromosomes confers adverse risk in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group. Blood 94:4036-4046
11. Hoelzer D, Gokbuget N, Ottmannn O, Pui CH, Relling MV, Appelbaum FR et al (2002) Acute lymphoblastic leukemia. Hematology 162-192 doi: 10.1182/ asheducation-2002.1.162
12. Hunger SP, Fall MZ, Camitta BM, Carroll AJ, Link MP, Lauer SJ et al (1998) E2A-PBX1 chimeric transcript status at end of consolidation is not predictive of treatment in childhood acute lymphoblastic leukemias with a t(1;19)(q23;p13): A Pediatric Oncology Group Study. Blood 91:1021-1028
13. ISCN (2005) An international system for human cytogenetic nomenclature. Karger, Basel
14. Johansson B, Moorman AV, Haas OA, Watmore AE, Cheung KL, Swanton S et al (1998) Hematologic malignances with t(4;11)(q21;q23) - a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. Leukemia 12:779-787 doi: 10.1038/sj.leu.2401012
15. Kager L, Lion T, Attarbaschi A, Koenig M, Strehl S, Haas OA et al (2007) Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Australian children. Haematologica 92:1561-1564 doi: 10.3324/ haematol.11239
16. Kearney L (1999) The impact of new FISH technologies on the cytogenetics of the haematological malignancies. Br J Haematol 104:648-658 doi: 10.1046/j.1365-2141.1999.01181.x
17. Kohlmann A, Schoch C, Dugas M, Hiddemann W, Kern W, Haferlach T (2004) Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an independent cohort of adult ALL patients. Leukemia 18:63-71 doi: 10.1038/sj.leu.2403167
18. Kubicka M, Soszynska K, Mucha B, Rafinska B, Kolodziej B, Haus O et al (2007) Unusual profile of pediatric acute lymphoblastic leukemia with MLL gene rearrangement. Leuk Lymphoma 48:2083-2086
19. Lee A, Kirk J, Edmands S, Radich J (1995) Multiplex PCR of bcr-abl fusion transcripts in Philadelphia positive acute lymphoblastic leukemia. PCR Methods Appl 4:283-287
20. Pui CH, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM et al (2003) Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements. Leukemia 17:700-706 doi: 10.1038/ sj.leu.2402883
21. Pui CH (2001) Risk assessment in acute lymphoblastic leukemia: Beyond leukemia cell characteristics. J Pediatr Hematol Oncol 23:405-407 doi: 10.1097/00043426-200110000-00002
22. Raimondi SC, Shurtleff SA, Downing JR, Rubnitz J, Mathew S, Hancock M et al (1997) 12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia. Blood 90:4559-4566
23. Raynaud SD, Dastugue N, Zoccola D, Shurtleff SA, Mathew S, Raimondi SC (1999) Cytogenetic abnormalities associated with the t(12;21): A collaborative study of 169 children with t(12;21) positive acute lymphoblastic leukemia. Leukemia 13:1325-1330 doi: 10.1038/sj/leu/2401506
24. Sawinska M, Ładon D (2004) Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q21) in the children suffering from acute lymphoblastic leukaemia. Leuk Res 28:35-42 doi: 10.1016/S0145-2126(03)00160-7
25. Schrappe M, Arico M, Harbott J, Biondi A, Zimmermann M, Conter V, Reiter A, Valsecchi MG, Gadner H, Basso G, Bartram CR, Lampert F, Riehm H, Masera G, for the German-Austrian-Swiss BFM Study Group and the Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP) (1998) Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: Good initial steroid allows early prediction of favorable treatment outcome. Blood 92:2730-2741
26. Uckun FM, Sensel MG, Sather HN, Gaynon PS, Arthur DC, Lange BJ et al (1998) Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: A report from the Children's Cancer Group. J Clin Oncol 16:527-535
27. Uckun FM, Sensel MG, Sun L, Steinhertz PG, Trigg ME, Heerema NA et al (1998) Biology and treatment of childhood T-lineage acute lymphoblastic leukemia. Blood 91:735-746
28. van der Burg M, Poulsen TS, Hunger SP, Baverloo HB, Smit EME, Vang-Nielsen K et al (2004) Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia. Leukemia 18:895-908 doi: 10.1038/sj.leu.2403340
29. van Dongen JJM, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio S et al (1999) Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action. Leukemia 13:1901-1928 doi: 10.1038/sj/leu/2401592