Thermoregulatory responses to environmental toxicants: The interaction of thermal stress and toxicant exposure

Toxicology and Applied Pharmacology

Volumn 233, Issue 1, 2008, Pages 146-161

  Leon, Lisa R ^a  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

Author keywords

Fever; Heat stress; Hypothermia; Organophosphates; Toxicology

Indexed keywords

CHEMICAL AGENT; ORGANOPHOSPHATE; REACTIVE OXYGEN METABOLITE;

ARTICLE; FEVER; HEAT STRESS; HUMAN; HYPOTHERMIA; LIPID PEROXIDATION; POLLUTANT; PROTECTION; SKIN ABSORPTION; SKIN BLOOD FLOW; SKIN PERMEABILITY; TEMPERATURE STRESS; THERMOREGULATION;

ANIMALS; BODY TEMPERATURE REGULATION; ENVIRONMENTAL EXPOSURE; FEVER; HAZARDOUS SUBSTANCES; HEAT STRESS DISORDERS; HUMANS; HYPOTHERMIA;

MAMMALIA; RODENTIA;

EID: 55649114401     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.01.012     Document Type: Article

References (151)

1. Adolph and associates. Physiology of Man in the Desert (1947), Intersciences, New York 157
2. Alarie Y. Irritating properties of airborne materials to the upper respiratory tract. Environ. Health 13 (1966) 433-449
3. Askew B.M. Hyperpyrexia as a contributory factor in the toxicity of amphetamine to aggregated mice. Brit. J. Pharmacol. 19 (1962) 245-257
4. Attia M., Khogali M., El-Khatib G., Mustafa M.K.E., Mahmoud M.A., Eldin A.N., and Gumaa K. Heat-stroke: an upward shift of temperature regulation set point at an elevated body temperature. Int. Arch. Occup. Environ. Health 53 (1983) 9-17
5. Austin M.G., and Berry J.W. Observations on one hundred cases of heatstroke. JAMA 161 (1956) 1525-1529
6. Baetjer A.M. Effects of season and temperature on childhood plumbism. Indust. Med. 28 (1959) 137-140
7. Baetjer A.M., and Horiguchi S. Effects of environmental temperature and dehydration on lead poisoning in laboratory animals. XIVth international congress of occupational health 62 (1964) 795-797
8. Baetjer A.M., and Smith R. Effect of environmental temperature on reaction of mice to parathion, an anticholinesterase agent. Am. J. Physiol. 186 (1956) 39-46
9. Baetjer A.M., Joardar S.N., and McQuary W.A. Effect of environmental temperature and humidity on lead poisoning in animals. Arch. Environ. Health 1 (1960) 463-477
10. Barnes B.M. Freeze avoidance in a mammal: body temperatures below 0 °C in an Arctic hibernator. Science 244 (1989) 1593-1595
11. Bejanian M., Finn D.A., Syapin P.J., and Alkana R.L. Body temperature and ethanol pharmacokinetics in temperature-challenged mice. Alcohol 7 (1990) 331-337
12. Blanc P., Wong H., Bernstein M.S., and Boushey H.A. An experimental model of metal fume fever. Ann. Intern. Med. 114 (1991) 930-936
13. Bouchama A., al-Sedairy S., Siddiqui S., Shail E., and Rezeig M. Elevated pyrogenic cytokines in heatstroke. Chest 104 (1993) 1498-1502
14. Bouchama A., Parhar R.S., el-Yazigi A., Sheth K., and al-Sedairy S. Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke. J. Appl. Physiol. 70 (1991) 2640-2644
15. Boyer B.B., Barnes B.M., Lowell B.B., and Grujic D. Differential regulation of uncoupling protein gene homologues in multiple tissues of hibernating ground squirrels. Am. J. Physiol. 275 (1998) R1232-R1238
16. Brown J.W., Whitehurst M.E., Gordon C.J., and Carroll R.G. Thermoregulatory set point decreases after hemorrhage in rats. Shock 23 (2005) 239-242
17. Bruce M.C., Bruce E.N., Leith D.E., and Murphy S.D. Mechanisms of maleate and/or ozone (10 ppm) reduce ventilation by 60-80% in awake mice. Physiologist 22 (1979) 16
18. Bruce-Low S.S., Cotterrell D., and Jones G.E. Effect of wearing personal protective clothing and self-contained breathing apparatus on heart rate, temperature and oxygen consumption during stepping exercises and live fire training exercises. Ergonomics 50 (2007) 80-98
19. Brunton T.L. Effect of warmth in preventing death from chloral. J. Anat. Physiol. 8 (1874) 332-339
20. Buchanan T.A., Cane P., Eng C.C., Sipos G.F., and Lee C. Hypothermia is critical for survival during prolonged insulin-induced hypoglycemia in rats. Metabolism 40 (1991) 330-334
21. Burgat-Sacaze V., Braun J.-P., Benard P., Eghbali B., and Rico A. Protection against mercuric chloride nephrotoxicity by cold exposure in rats. Toxicol. Lett. 10 (1982) 151-156
22. Calder W.A., and Schmidt-Nielsen K. Evaporative cooling and respiratory alkalosis in the pigeon. Proc. Natl. Acad. Sci. 55 (1966) 750-756
23. Cannon B., and Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84 (2004) 277-359
24. Carey H.V., Andrews M.T., and Martin S.L. Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature. Physiol. Rev. 83 (2003) 1153-1181
25. Carmichael E.A., and Fraser F.R. The effects of acetylcholine in man. Heart 16 (1933) 263-274
26. Carr R.L., and Chamgers J.E. Acute effects of the organophosphate paraoxon on schedule-controlled behavior and esterase activity in rats: dose-response relationships. Pharmacol. Biochem. Behav. 40 (1991) 929-936
27. Casarett L.J., and Doull J. Factors influencing toxicology. Toxicology: the Basic Sciences of Poisons (1975), Macmillan, New York 133-147
28. Cavalcante W.L., Silva M.D., and Gallacci M. Influence of temperature upon paralyzing and myotoxic effects of bothropstoxin-I on mouse neuromuscular preparations. Chem. Biol. Interact. 151 (2005) 95-100
29. Chang D.M. The role of cytokines in heat stroke. Immunol. Invest. 22 (1993) 553-561
30. Chang S.K., and Riviere J.E. Percutaneous absorption of parathion in vitro in porcine skin: effects of dose, temperature, humidity, and perfusate composition on absorptive flux. Fundam. Appl. Toxicol. 17 (1991) 494-504
31. Chang S.K., Brownie C., and Riviere J.E. Percutaneous absorption of topical parathion through porcine skin: in vitro studies on the effect of environmental perturbations. J. Vet. Pharmacol. Therap. 17 (1994) 434-439
32. Chayoth R., Kleinman D., Kaplanski J., and Sod Moriah U.A. Renal clearance of urea, inulin, and p-aminohippurate in heat-acclimated rats. J. Appl. Physiol. 57 (1984) 731-732
33. Chin J.H., and Goldstein D.B. Membrane-disordering action of ethanol. Variation with membrane cholesterol content and depth of the spin label probe. Mol. Pharmacol. 19 (1981) 425-431
34. Christoph R.A. Organophosphates and carbamates. Manual of Toxicologic Emergencies (1989), Year Book Medical Publishers, Inc., Chicago 626
35. Clement J.G. Variability of sarin-induced hypothermia in mice: investigation into incidence and mechanism. Biochem. Pharmacol. 42 (1991) 1316-1318
36. Craig F.N., Cummings E.G., and Sim V.M. Environmental temperature and the percutaneous absorption of a cholinesterase inhibitor, VS. J. Invest. Dermatol. 68 (1977) 357-361
37. Craig F.N., Bales P.D., and Frankel H.M. Lethality of sarin in a warm environment. J. Pharmacol. Exp. Ther. 127 (1959) 35-38
38. Craig T.V., Hunt W., and Atkinson R. Hypothermia - its use in severe carbon monoxide poisoning. N. Engl. J. Med. 261 (1959) 856
39. Crawford E.C. Mechanical aspects of panting in dogs. J. Appl. Physiol. 17 (1962) 249-251
40. Cupp C.M., Kleiber G., Reigart R., and Sandifer S.H. Hypothermia in organophosphate poisoning and response to PAM. JSC Med. Assoc. 71 (1975) 167-168
41. Dascombe M.J., Rothwell N.J., Sagay B.O., and Stock M.J. Pyrogenic and thermogenic effects of interleukin 1b in the rat. Am. J. Physiol. 256 (1989) E7-E11
42. Dietrich W.D., and Kuluz J.W. New research in the field of stroke: therapeutic hypothermia after cardiac arrest. Stroke 34 (2003) 1051-1053
43. Doi K., and Kuroshima A. Thermogenic response to glucagon in cold-acclimated mice. Jpn. J. Physiol. 32 (1982) 377-385
44. Doull J. The effect of physical environmental factors on drug response. Essays Toxicol. 3 (1972) 37-63
45. Dyer R.S., and Howell W.E. Triethyltin: ambient temperature alters visual system toxicity. Neurobehav. Toxicol. Teratol. 2 (1982) 267-271
46. Epstein Y., Arnon R., Moran D., Seidman D.S., and Danon Y. Effect of pyridostigmine on the exercise-heat response of man. Eur. J. Appl. Physiol. Occup. Physiol. 61 (1990) 128-132
47. Falus A., and Beres J. A trace element preparation containing zinc increases the production of interleukin-6 in human monocytes and glial cells. Biol. Trace Elem. Res. 51 (1996) 293-301
48. Fine J.M., Gordon T., Chen L.C., Kinney P., Falcone G., and Beckett W.S. Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value. J. Occup. Environ. Med. 39 (1997) 722-726
49. Finn D.A., Bejanian M., Jones B.L., Syapin P.J., and Alkana R.L. Temperature affects ethanol lethality in C57BL/6, 129, LS and SS mice. Pharmacol. Biochem. Behav. 34 (1989) 375-380
50. Flaim K.E., Horowitz J.M., and Horwitz B.A. Functional and anatomical characteristics of the nerve-brown adipose tissue interaction in the rat. Pflugers Arch. 365 (1976) 9-14
51. Funckes A.J., Hayes G.R., and Hartwell W.V. Urinary excretion of paranitrophenol by volunteers following dermal exposure to parathion at different ambient temperatures. Agricul. Food Chem. 11 (1963) 455-457
52. Fuhrman F.A. The effect of body temperature on drug action. Physiol. Rev. 26 (1946) 247-274
53. Fuhrman G.J., and Fuhrman F.A. Effects of temperature on the action of drugs. Ann. Rev. Pharmacol. 1 (1961) 65-78
54. Furchgott R.F., and Aawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature Lond. 288 (1980) 373-376
55. Gavrilova O., Leon L.R., Marcus-Samuels B., Mason M.M., Refetoff S., Vinson C., and Reitman M.L. Torpor in mice is induced by both leptin-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. 96 (1999) 14623-14628
56. Gearhart J.M., Seckel C., and Vinegar A. In vivo metabolism of chloroform in B6C3F1 mice determined by the method of gas uptake: the effects of body temperature on tissue partition coefficients and metabolism. Toxicol. Appl. Pharmacol. 119 (1993) 258-266
57. Glow P.H., and Rose S. Effects of reduced acetylcholinesterase levels on extinction of a conditioned response. Nature 206 (1965) 475-477
58. González Pondal M., Paier B., Noli M.I., Tudino M.B., Stripeikis J.D., Hagmüller K., and Zaninovich A. Changes induced by zinc on thyroxine deiodination by rat liver in vivo and in vitro. Acta Physiol. Pharmacol. Ther. Latinoam. 45 (1995) 35-41
59. Gordon C.J. Temperature and Toxicology. An integrative, Comparative, and Environmental Approach (2005), CRC Press, Boca Raton
60. Gordon C.J. Behavioral thermoregulatory response to chlorpyrifos in the rat. Toxicology 124 (1997) 165-171
61. Gordon C.J. Toxic-induced hypothermia and hypometabolism: do they increase uncertainty in the extrapolation of toxicological data from experimental animals to humans? Neurosci. Biobehav. Rev. 15 (1991) 95-98
62. Gordon C.J., and Mack C.M. Influence of gender on thermoregulation and cholinesterase inhibition in the Long-Evans rat exposed to diazinon. J. Toxicol. Environ. Health Part A 66 (2003) 291-304
63. Gordon C.J., and Mack C.M. Diurnal variation in thermoregulatory response to chlorpyrifos and carbaryl in the rat. Toxicology 169 (2001) 93-105
64. Gordon C.J., and Grantham T.A. Effect of central and peripheral cholinergic antagonists on chlorpyrifos-induced changes in body temperature in the rat. Toxicology 142 (1999) 15-28
65. Gordon C.J., and Fogelson L. Relationship between serum cholinesterase activity and the change in body temperature and motor activity in the rat: a dose response study of diisopropyl fluorophosphates. Neurotoxicol. Teratol. 15 (1993) 21-25
66. Gordon C.J., and Stead A.G. Effect of alcohol on behavioral and autonomic thermoregulation in mice. Alcohol 3 (1986) 339-343
67. Gordon C.J., Grantham T.A., and Yang Y. Hypothermia and delayed fever in the male and female rat exposed to chlorpyrifos. Toxicology 118 (1997) 149-158
68. Gordon C.J., Fogelson L., and Highfill J.W. Hypothermia and hypometabolisms: sensitive indices of whole-body toxicity following exposure to metallic salts in the mouse. J. Toxicol. Environ. Health 29 (1990) 185-200
69. Gordon C.J., Fogelson L., Mohler F., Stead A.G., and Rezvani A.H. Behavioral thermoregulation in the rat following the oral administration of ethanol. Alcohol Alcohol 23 (1988) 383-390
70. Gordon C.J., Long M.D., and Stead A.G. Thermoregulation in mice following acute chlordimeform administration. Toxicol. Lett. 28 (1985) 9-15
71. Graf R., Krishna S., and Heller H.C. Regulated nocturnal hypothermia induced in pigeons by food deprivation. Am. J. Physiol. 256 (1989) R733-R738
72. Gray E.L., Patton F.M., Goldberg S.B., and Kaplan E. Toxicity of the oxides of nitrogen. I. Introduction and apparatus. AMA Arch. Ind. Health 10 (1954) 409-417
73. Gunn J.W.C. The influence of temperature on the action of strophanthin on the mammalian heart. J. Pharmacol. Exper. Therap. 6 (1914) 39-44
74. Hammel H.T. Regulation of internal body temperature. Annu. Rev. Physiol. 30 (1968) 641-710
75. Hammel H.T., Wyndham C.H., and Hardy J.D. Heat production and heat loss in the dog at 8-36 °C environmental temperature. Am. J. Physiol. 194 (1958) 99-108
76. Hammami M.M., Bouchama A., Al-Sedairy S., Shail E., Al Ohaly Y., and Mohamed G.E. Concentrations of soluble tumor necrosis factor and interleukin-6 receptors in heatstroke and heatstress. Crit. Care Med. 25 (1997) 1314-1319
77. Hashim I.A., Al-Zeer A., Al-Shohaib S., Al-Ahwal M., and Shenkin A. Cytokine changes in patients with heatstroke during pilgrimage to Makkah. Mediat. Inflamm. 6 (1997) 135-139
78. Harris R.A., and Schroeder F. Ethanol and the physical properties of brain membranes: fluorescence studies. Mol. Pharmacol. 20 (1981) 128-137
79. Hassan M.R., Pesce A.J., Shen P., and Hanenson I.B. Correlation of serum pseudocholinesterase and clinical course of two patients poisoned with organophosphate insecticides. Clin. Toxicol. 18 (1981) 401-406
80. Heath J.E., Williams B.A., Mills S.H., and Kluger M.J. The responsiveness of the preoptic-anterior hypothalamus to temperature in vertebrates. In: South F.E. (Ed). Hibernation and Hypothermia, Perspectives and Challenges (1972), Elsevier, Amsterdam 605-627
81. Heron I., and Berg K. The actions of interferon are potentiated at elevated temperature. Nature Lond. 274 (1978) 508-510
82. Himms-Hagen J., Triandafillou J., and Gwilliam C. Brown adipose tissue of cafeteria-fed rats. Am. J. Physiol. 241 (1981) E116-E120
83. Holmer I., Kuklane K., and Gao C. Test of firefighter's turnout gear in hot and humid air exposure. Int. J. Occup. Saf. Ergon. 12 (2006) 297-305
84. Hood L.J. Myasthenia gravis: regimens and regimen-associated problems in adults. J. Neurosci. Nurs. 22 (1990) 358-364
85. Horn F., Wegenka U.M., Lutticken C., Yuan J., Roeb E., Boers W., Buschmann J., and Heinrich P.C. Regulation of alpha 2-macroglobulin gene expression by interleukin-6. Ann. N. Y. Acad. Sci. 737 (1994) 308-323
86. Ibuka N., and Fukumura K. Unpredictable deprivation of water increases the probability of torpor in the Syrian hamster. Physiol. Behav. 62 (1997) 551-556
87. IUPS Thermal Commission. Glossary of terms for thermal physiology. Third edition. Revised by the commission for thermal physiology of the international union of physiological sciences. Jap. J. Physiol. 51 (2001) 245-280
88. Jacobj C. Pharmakologische Untersuchung. uber das Colchicumgift. Arch. Exper. Path. Pharmacol. 27 (1890) 119-157
89. Jaeger R.J., and Gearhart J.M. Respiratory and metabolic response of rat and mice to formalin vapor. Toxicology 25 (1982) 299-309
90. Johansen K.S., Berger E.M., and Repine J.E. Effect of temperature on polymorphonuclear leukocyte function. Acta Pathol. Microbiol. Immunol. Scand. Sect. C Immunol. 91 (1983) 355-359
91. Keeler J.R., Hurst C.G., and Dunn M.A. Pyridostigmine used as a nerve agent pretreatment under wartime conditions. JAMA 266 (1991) 693-695
92. Keplinger M.L., Lanier G.E., and Deichmann W.G. Effects of environmental temperature on the acute toxicity of a number of compounds in rats. Toxicol. Appl. Pharmacol. 1 (1959) 156-161
93. Klaassan C.D., and Eaton D.L. Principles of toxicology. In: Amdur M.O., Doull J., and Klaassen C.D. (Eds). Casarett and Doull's Toxicology: the Basic Science of Poisons (1991), Pergamon Press, New York 12-49
94. Klein M.S., Conn C.A., and Kluger M.J. Behavioral thermoregulation in mice inoculated with influenza virus. Physiol. Behav. 52 (1992) 1133-1139
95. Klemmer H.W., Reichert E.R., and Yauger W.L. Five cases of intentional ingestion of 25 percent diazinon with treatment and recovery. Clin. Toxicol. 12 (1978) 435-444
96. Kluger M.J. Fever: role of pyrogens and cryogens. Physiol. Rev. 71 (1991) 93-127
97. Kolka M.A., and Stephenson L.A. Cutaneous blood flow and local sweating after systemic atropine administration. Pfluegers Arch. 410 (1987) 524-529
98. Kozar M.D., Overstreet D.H., Chippendale T.C., and Russell R.W. Changes of acetylcholinesterase activity in three major brain areas and related changes in behaviour following acute treatment with diisopropyl fluorophosphates. Neuropharmacology 15 (1976) 291-298
99. Kurtz C.C., Lindell S.L., Mangino M.J., and Carey H.V. Hibernation confers resistance to intestinal ischemia-reperfusion injury. Am. J. Physiol. 291 (2006) G895-G901
100. Lafranconi W.M., and Huxtable R.J. Hepatic metabolism and pulmonary toxicity of monocrotaline using isolated perfused liver and lung. Biochem. Pharmacol. 33 (1984) 2479-2484
101. Lash L.H., Qian W., Putt D.A., Hueni S.E., Elfarra A.A., Krause R.J., and Parker J.C. Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences. J. Pharmacol. Exper. Therap. 179 (2001) 163-171
102. Leftwich R.B., Floro J.F., Neal R.A., and Wood A.J.J. Dinitrophenol poisoning: a diagnosis to consider in undiagnosed fever. Southern Med. J. 75 (1982) 182-184
103. Leon L.R., DuBose D.A., and Mason C.D. Heat stress induces a biphasic thermoregulatory response in mice. Am. J. Physiol. 288 (2005) R197-R204
104. Leon L.R., White A.A., and Kluger M.J. Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice. Am. J. Physiol. 275 (1998) R269-R277
105. Li L.X., Skorpen F., Egeberg K., Jorgensen I.H., and Grill V. Uncoupling protein-2 participates in cellular defense against oxidative stress in clonal beta-cells. Biochem. Biophys. Res. Commun. 282 (2001) 273-277
106. Liebermeister C. Vorlesungen uber specielle pathologie und therapie (1887), Verlag-Vogel, Lepzig, Germany
107. Lu K.-C., Wang J.-Y., Lin S.-H., Chu P., and Lin Y.-F. Role of circulating cytokines and chemokines in exertional heatstroke. Crit. Care Med. 32 (2004) 399-403
108. Lyman C.P. Pharmacological aspects of mammalian hibernation. In: E. Schonbaum E., and Lomax P. (Eds). Thermoregulation: Physiology and Biochemistry (1990), Pergamon Press, New York 415-436
109. Maickel R.P., Kinney D.R., and Nichols M.B. Antagonism of physostigmine induced hypothermia and neuroendocrine changes following exposure to different environmental temperatures. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 15 (1991) 873-884
110. Malcolm R.D., and Alkana R.L. Temperature dependence of ethanol lethality in mice. J. Pharm. Pharmacol. 35 (1983) 306-311
111. Malamud N., Haymaker W., and Custer R.P. Heat stroke. Mil. Surg. 99 (1946) 397-449
112. Malvin G.M., and Wood S.C. Behavioral hypothermia and survival of hypoxic protozoans Paramecium caudatum. Science 255 (1992) 1423-1425
113. Marion D.W., Penrod L.E., Kelsey S.F., Obrist W.D., Kochanek P.M., Palmer A.M., Wisniewski S.R., and DeKosky S.T. Treatment of traumatic brain injury with moderate hypothermia. N. Engl. J. Med. 336 (1997) 540-546
114. McLemore G.A., and Craig F.N. Retention of inhaled sarin by running dogs. J. Pharmacol. Exp. Ther. 126 (1959) 278-282
115. McMaster S.B., and Finger A.V. Effects of exercise on behavioral sensitivity to carbamate cholinesterase inhibitors. Pharmacol. Biochem. Behav. 33 (1989) 811-813
116. McMaster S.B., and Carney J.M. Chronic exercise produces tolerance to muscarinic antagonists in rats. Pharmacol. Biochem. Behav. 24 (1986) 865-868
117. Meeter E. The mode of action of cholinesterase inhibitors on the temperature regulation of the rat. Arch. Int. Pharmacodyn. 182 (1969) 416-419
118. Mermier C.M., Schneider S.M., Gurney A.B., Weingart H.M., and Wilmerding M.V. Preliminary results: effect of whole-body cooling in patients with myasthenia gravis. Med. Sci. Sports Exerc. 38 (2006) 13-20
119. Namba T., Nolte C.T., Jackrel J., and Grob D. Poisoning due to organophosphate insecticides. Am. J. Med. 50 (1971) 475-492
120. Nomiyama K., Matsui K., and Nomiyama H. Environmental temperature, a factor modifying the acute toxicity of organic solvents, heavy metals, and agricultural chemicals. Toxicol. Lett. 6 (1980) 67-70
121. Paier B., Pavia M.A., Hansi C., Noli M.I., Hagmüller K., and Zaninovich A. Cadmium inhibits the in vitro conversion of thyroxine to triiodothyronine in rat brown adipose tissue. Bull. Environ. Contam. Toxicol. 59 (1997) 164-170
122. Perkins E.J., Bao W., Guan X., Ang C.Y., Wolfinger R.D., Chu T.M., Meyer S.A., and Inouye L.S. Comparison of transcriptional responses in liver tissues and primary hepatocyte cell cultures after exposure to hexahydro-1,3,5-trinitro-1,3,5-triazine. BMC Bioinformatics 7 (2006) S22
123. Pfeiffer C., Foster M.A., and Slight D. The effect of analeptic drugs on hibernation in the thirteen-lined ground squirrel. J. Pharmacol Exp. Ther. 67 (1939) 307-312
124. Phillips P.K., and Heath J.E. Dependency of surface temperature regulation on body size in terrestrial mammals. J. Therm. Biol. 20 (1995) 281-289
125. Postlethwait E.M., Langford S.D., and Bidani A. Determinants of inhaled ozone absorption in isolated rat lungs. Toxicol. Appl. Pharmacol. 125 (1994) 77-89
126. Ray D.E., Roubicek C.B., and Hamidi M. Organ and gland weights of rats chronically exposed to 22° and 35 °C. Growth 32 (1968) 1-12
127. Ricquier D., Mory G., and Hemon P. Changes induced by cold adaptation in the brown adipose tissue from several species of rodents, with special reference to mitochondrial components. Can. J. Biochem. 57 (1979) 1262-1266
128. Riviere J.E., and Williams P.L. On pharmacokinetic implication of changing blood in the skin. J. Pharm. Sci. 81 (1992) 601-602
129. Roddie I.C., Shepherd J.T., and Whelan R.F. The contribution of constrictor and dilator nerves to the skin vasodilatation during body heating. J. Physiol. Lond. 136 (1957) 489-497
130. Romanovsky A.A., and Blatteis C.M. Heat stroke: opioid-mediated mechanisms. J. Appl. Physiol. 81 (1996) 2565-2570
131. Romm E., and Collins A.C. Body temperature influences on ethanol elimination rate. Alcohol 4 (1987) 189-198
132. Rowsey P.J., Metzger B.L., Carlson J., and Gordon C.J. Effects of exercise conditioning on thermoregulatory responses to repeated administration of chlorpyrifos. Environ. Res. 92 (2003) 27-34
133. Rutkove S.B. Effects of temperature on neuromuscular electrophysiology. Muscle Nerve 24 (2001) 867-882
134. Saadeh A.M., Al-Ali M.K., Farsakh N.A., and Ghani M.A. Clinical and sociodemographic features of acute carbamate and organophosphate poisoning: a study of 70 adult patients in North Jordan. Clin. Toxicol. 34 (1996) 45-51
135. Shimuzu Y., and Saito M. Activation of brown adipose tissue thermogenesis in recovery from anesthetic hypothermia in rats. Am. J. Physiol. 261 (1991) R301-R304
136. Simon E. Effects of CNS temperature on generation and transmission of temperature signals in homeothermia. A common concept for mammalian and avian thermoregulation. Pflugers Arch. 392 (1981) 79-88
137. Slade R., Watkins W.P., and Hatch G.E. Mouse strain differences in ozone dosimetry and body temperature changes. Am. J. Physiol. 272 (1997) L73-L77
138. Snodgrass H.L. Permethrin transfer from treated cloth to the skin surface: potential for exposure in humans. J. Toxicol. Environ. Health 35 (1992) 91-105
139. Sonna L.A., Wenger C.B., Flinn S., Sheldon H.K., Sawka M.N., and Lilly C.M. Exertional heat injury and gene expression changes: a DNA microarray analysis study. J. Appl. Physiol. 96 (2004) 1943-1953
140. Spencer P.S., McCauley L.A., Lapidus J.A., Lasarev M., Joos S.K., and Storzbach D. Self-reported exposures and their association with unexplained illness in a population-based case-control study of Gulf War veterans. J. Occup. Environ. Med. 43 (2001) 1041-1456
141. Stephenson L.A., and Kolka M.A. Acetylcholinesterase inhibitor, pyridostigmine bromide, reduces skin blood flow in humans. Am. J. Physiol. 258 (1990) 951-957
142. Walker S.M., Ackland T.R., and Dawson B. The combined effect of heat and carbon monoxide on the performance of motorsport athletes. Comp. Biochem. Physol. A 128 (2001) 709-718
143. Wang L.C.H., and Peter R.E. Metabolic and respiratory responses during Helox-induced hypothermia in the white rat. Am. J. Physiol. 229 (1975) 890-895
144. Watanabe C., Suzuki T., and Matsuo N. Toxicity modification of sodium selenite by a brief exposure to heat or cold in mice. Toxicology 64 (1990) 245-253
145. Wenger C.B., and Latzka W.A. Effects of pyridostigmine bromide on physiological responses to heat, exercise, and hypohydration. Aviat. Space Environ. Med. 63 (1992) 37-45
146. Wenger B., Quigley M.D., and Kolka M.A. Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. Aviat. Space Environ. Med. 64 (1993) 905-911
147. Wester R.C., Quan D., and Maibach H.I. In vitro percutaneous absorption of model compounds glyphosate and malathion from cotton fabric into and through human skin. Food Chem. Toxicol. 34 (1996) 731-735
148. Wilkinson D.A., Burholt D.R., and Shrivastava P.N. Hypothermia following whole-body heating of mice: effect of heating time and temperature. Int. J. Hypertherm. 4 (1988) 171-182
149. Wood S., Rom W.N., White G.L., and Logan D.C. Pentachlorophenol poisoning. J. Occup. Med. 25 (1983) 527-530
150. Wright G.L. Critical thermal maximum in mice. J. Appl. Physiol. 40 (1976) 683-687
151. Young J.F., and Haley T.J. A pharmacokinetic study of pentachlorophenol poisoning and the effect of forced diuresis. Chem. Toxicol. 12 (1978) 41-48