Effects of feeding L-carnitine to gilts through day 70 of gestation on litter traits and the expression of insulin-like growth factor system components and L-carnitine concentration in foetal tissues

Journal of Animal Physiology and Animal Nutrition

Volumn 92, Issue 6, 2008, Pages 660-667

  Brown, K R ^a   Goodband, R D ^a   Tokach, M D ^a   Dritz, S S ^a   Nelssen, J L ^a   Minton, J E ^a   Higgins, J J ^a   Lin, X ^b   Odle, J ^b   Woodworth, J C ^c   Johnson, B J ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c Lonza Inc USA   (United States)

Author keywords

Foetus; Gestation; Gilts; L carnitine; Messenger RNA

Indexed keywords

CARNITINE; MESSENGER RNA; SOMATOMEDIN; SOMATOMEDIN C;

ANIMAL; ANIMAL FOOD; ARTICLE; BLOOD; BREEDING; DIET SUPPLEMENTATION; DRUG EFFECT; FEMALE; FETUS DEVELOPMENT; GESTATIONAL AGE; GROWTH, DEVELOPMENT AND AGING; LIVER; METABOLISM; PHYSIOLOGY; PREGNANCY; RANDOMIZATION; SKELETAL MUSCLE; SWINE;

ANIMAL FEED; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; CARNITINE; DIETARY SUPPLEMENTS; FEMALE; FETAL DEVELOPMENT; GESTATIONAL AGE; INSULIN-LIKE GROWTH FACTOR I; LIVER; MUSCLE, SKELETAL; PREGNANCY; PREGNANCY, ANIMAL; RANDOM ALLOCATION; RNA, MESSENGER; SOMATOMEDINS; SWINE;

SUIDAE;

EID: 55649112498     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2007.00762.x     Document Type: Article

References (27)

1. Aherne, F. X. Kirkwood, R. N., 1985 : Nutrition and sow prolificacy. Journal of Reproduction and Fertility 33, 169 183.
2. Alvestrand, A. Hagenfelt, L. Merli, M. Oureshi, A. Eriksson, L. S., 1990 : Influence of leucine infusion on intracellular amino acids in humans. European Journal of Clinical Investigation 20, 293 298.
3. Bhuiyan, A. K. Jackson, S. Turnbull, D. M. Aynsley-Green, A. Leonard, J. V. Bartlett, K., 1992 : The measurement of carnitine and acyl-carnitines: application to the investigation of parents with suspected inherited disorders of mitochondrial fatty acid oxidation. Clinica Chimica Acta 207, 185 204.
4. Birkenfeld, C. Doberenz, J. Kluge, H. Eder, K., 2006 : Effect of L-carnitine supplementation to sows on L-carnitine status, body composition and concentrations of lipids in liver and plasma of their piglets at birth and during the suckling period. Animal Feed Science and Technology 129, 23 28.
5. Birkenfeld, C. Ramanau, A. Kluge, H. Spilke, J. Eder, K., 2005 : Effect of dietary L-carnitine supplementation on growth performance of piglets from control sows or sows treated with L-carnitine during pregnancy and lactation. Journal of Animal Physiology and Animal Nutrition 89, 277 283.
6. Bohles, H. Lehnert, W., 1984 : The effect of intravenous L-carnitine on propionic acid excretion in acute propionic academia. European Journal of Pediatrics 143, 61 63.
7. Brameld, J. M. Mostyn, A. Dandrea, J. Stephenson, T. J. Dawson, J. M. Buttery, P. J. Symonds, M. E., 2000 : Maternal nutrition alters the expression of insulin-like growth factors in fetal sheep liver and skeletal muscle. Journal of Endocrinology 167, 429 437.
8. Brown, A. L. Graham, D. E. Nissley, S. P. Hill, D. J. Strain, A. J. Rechler, M. M., 1986 : Developmental regulation of insulin-like growth factor II mRNA in different rat tissues. Journal of Biological Chemistry 261, 13144 13150.
9. Brown, K. R. Goodband, R. D. Tokach, M. D. Dritz, S. S. Nelssen, J. L. Minton, J. E. Higgins, J. J. Woodworth, J. C. Johnson, B. J., 2007 : Growth characteristics, blood metabolites, and insulin-like growth factor system components in maternal tissues of gilts fed L-carnitine through day seventy of gestation. Journal of Animal Science 85, 1687 1694.
10. Doberenz, J. Birkenfeld, C. Kluge, H. Eder, K., 2006 : Effects of L-carnitine supplementation in pregnant sows on plasma concentrations of insulin-like growth factors, various hormones and metabolites and chorion characteristics. Journal of Animal Physiology and Animal Nutrition 90, 487 499.
11. Eder, K. Ramanau, A. Kluge, H., 2001 : Effect of L-carnitine supplementation on performance parameters in gilts and sows. Journal of Animal Physiology and Animal Nutrition 85, 73 80.
12. Florini, J. R. Magri, K. A. Ewton, D. Z. James, P. L. Grindstaff, K. Rotwein, P. S., 1991 : 'Spontaneous' differentiation of skeletal myoblasts is dependent upon autocrine secretion of insulin-like growth factor-II. Journal of Biological Chemistry 266, 15917 15923.
13. Higgins, J. J., 2004 : An Introduction to Modern Nonparametric Statistics. Brooks/Cole Thomson Learning, Inc., Pacific Grove, CA.
14. Hill, D. J., 1990 : Relative abundance and molecular size of immunoreactive insulin-like growth factors I and II in human fetal tissues. Early Human Development 21, 49 58.
15. Hills, F. A. English, J. Chard, T., 1996 : Circulating levels of IGF-I and IGF-binding protein throughout pregnancy: relation to birthweight and maternal weight. Journal of Endocrinology 148, 303 309.
16. Jacobs, S., 2002 : Practical experiences with l-carnitine. Lohman Information International 26, 21 24.
17. Lin, X. Odle, J., 2003 : Changes in kinetics of carnitine palmitoyltransferase in liver and skeletal muscle of dogs (Canis familiaris) throughout growth and development. Journal of Nutrition 133, 1113 1119.
18. McGarry, J. P. Foster, D. W., 1976 : An improved and simplified radioisotope assay for the determination of free and esterfied carnitine. Journal of Lipid Research 17, 277 281.
19. Moses, A. C. Nissely, S. P. Short, P. A. Rechler, M. M. White, R. M. Knight, A. B. Higa, O. Z., 1980 : Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum. Proceedings of the National Academy of Sciences of the United States of America 77, 3649 3653.
20. Musser, R. E. Goodband, R. D. Tokach, M. D. Owen, K. Q. Nelssen, J. L. Blum, S. A. Dritz, S. S. Civis, C. A., 1999 : Effect of L-carnitine fed during gestation and lactation on sow and litter performance. Journal of Animal Science 77, 3289 3295.
21. NRC, 1998 : Nutrient Requirements of Swine, 10th edn. National Academy Press, Washington, DC.
22. Owen, K. Q. Ji, H. Maxwell, C. V. Nelssen, J. L. Goodband, R. D. Tokach, M. D. Tremblay, G. C. Koo, S. I., 2001 : Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics in swine. Journal of Animal Science 79, 3104 3112.
23. Ramanau, A. Kluge, H. Spilke, J. Eder, K., 2002 : Reproductive performance of sows supplemented with dietary L-carnitine over three reproductive cycles. Archives of Animal Nutrition 56, 287 296.
24. Ramanau, A. H. Kluge, H. Spilke, J. Eder, K., 2004 : Supplementation of sows with L-carnitine during pregnancy and lactation improves growth of the piglets during the suckling period through increased milk production. Journal of Nutrition 134, 86 92.
25. Ramanau, A. H. Kluge, H. Eder, K., 2005 : Effects of L-carnitine supplementation on milk production, litter gains and backfat thickness in sows with a low energy and protein intake during lactation. British Journal of Nutrition 93, 717 721.
26. Waylan, A. T. Kayser, J. P. Gnad, D. P. Higgins, J. J. Starkey, J. D. Sissom, E. K. Woodworth, J. C. Johnson, B. J., 2005 : Effects of L-carnitine on fetal growth and the IGF system in pigs. Journal of Animal Science 83, 1824 1831.
27. Williams, I. H. Close, W. H. Cole, D. J. A., 1985 : Strategies for sow nutrition: Predicting the response of pregnant animals to protein and energy intake. In : W. Haresign, D. J. A. Cole (eds Recent Advances in Animal Nutrition. Butterworth, London.