Effect of l-carnitine supplementation of sows on l-carnitine status, body composition and concentrations of lipids in liver and plasma of their piglets at birth and during the suckling period

Animal Feed Science and Technology

Volumn 129, Issue 1-2, 2006, Pages 23-38

  Birkenfeld, C ^a   Doberenz, J ^a   Kluge, H ^a   Eder, K ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Body composition; IGF 1; Insulin; l Carnitine; Lipids; Piglet; Sow

Indexed keywords

EID: 33745271844     PISSN: 03778401     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anifeedsci.2005.12.007     Document Type: Article

References (41)

1. Armstrong J.D., Coffey M.T., Esbenshade K.L., Campbell R.M., and Heimer E.P. Concentrations of hormones and metabolites, estimates of metabolism, performance, and reproductive performance of sows actively immunized against growth hormone-releasing factor. J. Anim. Sci. 72 (1994) 1570-1577
2. Auldist D.E., Morrish L., Thompson M., and King R.H. Response of sows to varying litter size. Proc. Nutr. Soc. Aust. 18 (1994) 175
3. Baltzell J.K., Bazer F.W., Miguel S.G., and Borum P.R. The neonatal piglet as a model for human neonatal carnitine metabolism. J. Nutr. 117 (1987) 754-757
4. Bassler R., and Buchholz H. Methodenbuch Band III. Die chemische Untersuchung von Futtermitteln, 3. Ergänzungslieferung (1993), VDLUFA-Verlag, Darmstadt
5. Borum P.R. Carnitine. Annu. Rev. Nutr. 3 (1983) 233-259
6. Bremer J. Carnitine in intermediary metabolism-the biosynthesis of palmitoylcarnitine by cell subfractions. J. Biol. Chem. 238 (1963) 2774-2779
7. Cagen L.M., Deng X., Wilcox H.G., Park E.A., Raghow R., and Elam M.B. Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. Biochem. J. 385 (2005) 207-216
8. Coffey T.M., Shireman R.B., Herman D.L., and Jons E.E. Carnitine status and lipid utilization in neonatal piglets fed diets low in carnitine. J. Nutr. 121 (1991) 1047-1053
9. De Hoff J.L., Davidson J.H., and Kritchevsky V. An enzymatic assay for determining free and total cholesterol in tissues. Clin. Chem. 24 (1978) 433-435
10. Eder K., Ramanau A., and Kluge H. Effect of l-carnitine supplementation on performance parameters in gilts and sows. J. Anim. Physiol. Anim. Nutr. 85 (2001) 73-80
11. Eder K., Peganova S., and Kluge H. Studies on the tryptophan requirement of piglets. Arch. Anim. Nutr. 55 (2001) 281-297
12. Elsey F.W.H. Nutrition and lactation in the sow. In: Falconer I.R. (Ed). Lactation (1971), Butterworths, London 393-411
13. Etienne M., Dourmad J.-Y., and Noblet J. The influence of some sow and piglet characteristics and of environmental conditions on milk production. In: Verstegen M.W.A., Moughan P.J., and Schrama J.W. (Eds). The Lactating Sow (1998), Wageningen Pers, Wageningen, The Netherlands 285-299
14. Flores C.A., Hu C., Edmond J., and Koldovsky O. Milk carnitine affects organ carnitine concentration in newborn rats. J. Nutr. 126 (1996) 1673-1682
15. Fontaine J., Bech-Andersen S., Bütikofer U., and De Froidmont-Görtz I. Determination of tryptophan in feed by HPLC-development of an optimal hydrolysis and extraction procedure by the EU Commission DG XII in three international collaborative studies. Agribiol. Res. 51 (1998) 97-108
16. Gesellschaft für Ernährungsphysiologie (GfE, Ausschuß für Bedarfsnormen), 1987. Energie-und Nährstoffbedarf landwirtschaftlicher Nutztiere, Nr. 4 Schweine, DLG-Verlag, Frankfurt/Main, Germany, pp. 30-43.
17. Gluckman P.D. Insulin-like growth factors and their binding proteins. In: Hanson M.A., Spencer J.A.D., and Rodeck C.H. (Eds). Fetus and Neonate Growth vol. 3 (1995), Cambridge University Press, Cambridge, UK 97-116
18. Gluckman P.D. Endocrine and nutritional regulation of prenatal growth. Acta Paediatr. Suppl. 423 (1997) 153-157
19. Hara A., and Radin S.N. Lipid extraction of tissues with a low-toxicity solvent. Anal. Biochem. 90 (1978) 420-426
20. Heo K., Odle J., Han I.K., Cho W., Seo S., Van Heugten E., and Pilkington D.H. Dietary l-carnitine improves nitrogen utilisation in growing pigs fed low energy, fat-containing diets. J. Nutr. 130 (2000) 1809-1814
21. Kelley R.L., Jungst S.B., Spencer T.E., Owsley W.F., Rahe C.H., and Mulvaney D.R. Maternal treatment with somatotropin alters embryonic development and early postnatal growth of pigs. Domest. Anim. Endocrinol. 12 (1995) 83-94
22. Kveragas C.L., Seerley R.W., Martin R.J., and Vandergrift W.L. Influence of exogenous growth hormone and gestational diet on sow blood and milk characteristics and on baby pig blood, body composition and performance. J. Anim. Sci. 63 (1986) 1877-1887
23. Lee C.Y., Bazer F.W., Etherton T.D., and Simmen F.A. Ontogeny of insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in porcine serum during fetal and postnatal development. Endocrinology 128 (1991) 2336-2344
24. McGarry J.D., and Foster D.W. An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. J. Lipid Res. 17 (1976) 277-281
25. Musser R.E., Goodband R.D., Tokach M.D., Owen K.Q., Nelssen J.L., Blum S.A., Dritz S.S., and Civis C.A. Effects of l-carnitine fed during gestation and lactation on sow and litter performance. J. Anim. Sci. 77 (1999) 3289-3295
26. Noblet J., Etienne M., and Dourmad J.-Y. Energetic efficiency of milk production. In: Verstegen M.W.A., Moughan P.J., and Schrama J.W. (Eds). The Lactating Sow (1998), Wageningen Pers, Wageningen, The Netherlands 113-130
27. Owen K.Q., Nelssen J.L., Goodband R.D., Tokach M.D., and Friesen K.G. Effect of dietary l-carnitine on growth performance and body composition in nursery and growing-finishing pigs. J. Anim. Sci. 79 (2001) 1509-1515
28. Owen K.Q., Ji H., Maxwell C.V., Nelssen J.L., Goodband R.D., Tokach M.D., Tremblay G.C., and Koo I.S. Dietary l-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine. J. Anim. Sci. 79 (2001) 3104-3112
29. Owen K.Q., Nelssen J.L., Goodband R.D., Weeden T.L., and Blum S.A. Effect of l-carnitine and soybean oil on growth performance and body composition of early-weaned pigs. J. Anim. Sci. 74 (1996) 1612-1619
30. Owens P.C., Conlon M.A., Campbell R.G., Johnson R.J., King R., and Ballard F.J. Developmental changes in growth hormone, insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in plasma of young growing pigs. J. Endocrinol. 124 (1991) 269-275
31. Ramanau A., Kluge H., Spilke J., and Eder K. Reproductive performance of sows supplemented with dietary l-carnitine over three reproductive cycles. Arch. Anim. Nutr. 56 (2002) 287-296
32. Ramanau A., Kluge H., Spilke J., and Eder K. Supplementation of sows with l-carnitine during pregnancy and lactation improves growth of the piglets during the suckling period through increased milk production. J. Nutr. 134 (2004) 86-92
33. Rehfeldt C., Nissen P.M., Kuhn G., Vestergaard M., Ender K., and Oksbjerg N. Effects of maternal nutrition and porcine growth hormone (pGH) treatment during gestation on endocrine and metabolic factors in sows, fetuses and pigs, skeletal muscle development, and postnatal growth. Domest. Anim. Endocrinol. 27 (2004) 267-285
34. SAS, 2004. SAS User Guide, Version 9.1.3, SAS Institute Inc., Cary, NC.
35. Shimano H. Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog. Lipid Res. 40 (2001) 439-452
36. Sterle J.A., Cantley T.C., Lamberson W.R., Lucy M.C., Gerrard D.E., Matteri R.L., and Day B.N. Effects of recombinant porcine somatotropin on placental size, fetal growth and IGF-1 and IGF-2 concentration in pigs. J. Anim. Sci. 73 (1995) 2980-2985
37. Tiedink H.G.M., and Katan M.B. Variability in lipoprotein concentrations in serum after prolonged storage at -20 °C. Clin. Chim. Acta 180 (1989) 147-156
38. Thissen J.P., Ketelslegers J.M., and Underwood L.E. Nutritional regulation of the insulin-like growth factors. Endocr. Rev. 15 (1994) 80-101
39. Warshaw J.B., and Curry E. Comparison of serum carnitine and ketone body concentrations in breast- and in formula-fed newborn infants. J. Pediatr. 97 (1980) 122-125
40. Waylan A.T., Kayser J.P., Gnad D.P., Higgins J.J., Starkey J.D., Sissom E.K., Woodworth J.C., and Johnson B.J. Effect of l-carnitine on fetal growth and the IGF system in pigs. J. Anim. Sci. 83 (2005) 1824-1831
41. Yellaturu C.R., Deng X., Cagen L.M., Wilcox H.G., Park E.A., Raghow R., and Elam M.B. Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP. Biochem. Biophys. Res. Commun. 332 (2005) 174-180