Desialylation of human apolipoprotein E decreases its binding to human high-density lipoprotein and its ability to deliver esterified cholesterol to the liver

Metabolism: Clinical and Experimental

Volumn 48, Issue 9, 1999, Pages 1184-1192

  Marmillot, Philippe ^b   Rao, Manjunath N ^b   Liu, Qing Hong ^b   Lakshman, M Raj ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN;

ARTICLE; CELL STRAIN HEPG2; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; SIALYLATION;

EID: 0032820681     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(99)90136-1     Document Type: Article

References (68)

1. Basu SK, Goldstein JL, Brown MS: Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages. Science 219:871-873, 1983
2. Zannis VI, McPherson J. Goldberger G, et al: Synthesis, intracellular processing, and signal peptide of human apolipoprotein E. J Biol Chem 259:5495-5499, 1984
3. Zannis VI, van der Spek J, Silverman D: Intracellular modifications of human apolipoprotein E. J Biol Chem 261:13415-13421, 1986
4. Mahley RW: Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 240:622-630, 1988
5. Rubinstein DC: Apolipoprotein E: A review of its roles in lipoprotein metabolism, neuronal growth and repair and as a risk factor for Alzheimer's disease. Psychol Med 25:223-229, 1995
6. Zannis VI, Breslow JL: Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. Biochemistry 20:1033-1041. 1981
7. Gotto AM, Pownall HJ, Havel RJ: Introduction to the plasma hpoproteins. Methods Enzymol 128:3-41, 1986
8. Glomset JA: The plasma lecithin:cholesterol acyltransferase reaction. J Lipid Res 9:155-167, 1968
9. Pitas RE, Innerarity TL, Arnold KS, et al: Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: Evidence for multiple receptor binding of apo-E HDLc. Proc Natl Acad Sci USA 76:2311-2315, 1979
10. Barter PJ, Hopkins GJ, Calvert GD: Transfers and exchanges of esterified cholesterol between plasma lipoproteins. Biochem J 208:1-7, 1982
11. Rifici VA, Eder HA: A hepatocyte receptor for high-density lipoproteins specific for apolipoprotein A-I. J Biol Chem 259:13814-13818, 1984
12. Hoeg JM, Demosky SJ, Edge SB, et al: Characterization of a human hepatic receptor for high density lipoprotein. Arteriosclerosis 5:228-237, 1985
13. Tall AR. Plasma high density lipoproteins. Metabolism and relationship to atherogenesis. J Clin Invest 86:379-384, 1990
14. Ghosh P, Chirtel SJ, Lakshman MR: Effect of chronic ethanol on apolipoprotein (apo) E synthesis and glycosylation in rats Alcohol Clin Exp Res 15:725-729, 1991
15. Lakshman MR, Chirtel SJ, Chambers LL: Roles of omega 3 fatty acids and chronic ethanol in the regulation of plasma and liver lipids and plasma apoproteins Al and E in rats. J Nutr 118:1299-1303, 1988
16. Lin RC, Lumeng L, Phelps VL: Serum high-density lipoprotein particles of alcohol-fed rats are deficient in apolipoprotein E. Hepatology 9:307-313, 1989
17. Lin RC, Miller BA, Kelly TJ: Concentrations of apolipoprotein AI, AII, and E in plasma and lipoprotein fractions of alcoholic patients: Gender differences in the effects of alcohol. Hepatology 21:942-949, 1995
18. Wernette-Hammond ME, Lauer SJ, Corsini A, et al: Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194. J Biol Chem 264.9094-9101, 1989
19. Rail SC, Weisgraber KH, Inneranty TL, et al: Plasma lipoprotein: apolipoprotein structure and function. Circulation 72:143, 1985 (abstr)
20. Schumaker VN, Puppione DL: Sequential flotation ultracentrifugation. Methods Enzymol 128:155-170, 1986
21. Allain CC, Poon LS, Chan CS, et al: Enzymatic determination of total serum cholesterol. Clin Chem 20:470-475, 1974
22. McGowan MW, Artiss JD, Strandbergh DR, et al: A peroxidasecoupled method for the colorimetric determination of serum triglycerides. Clin Chem 29:538-542, 1983
23. Bartlett GR: Phosphorus assay in column chromatography. J Biol Chem 234:466-468, 1959
24. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
25. Rail SC, Karl JH, Weisgraber KH, et al. Isolation and characterization of apolipoprotein E. Methods Enzymol 128:273-287, 1986
26. Horgan IE: A modified spectrophotometric method for determination of nanogram quantities of sialic acid. Clin Chim Acta 116:409-415, 1981
27. Irie S, Minguell JJ, Tavassoli M: Comparison of desialylation of rat transferrin by cellular and non-cellular methods. Biochem J 259:427-431, 1989
28. Wang XC, O'Hanlon TP, Lau JT: Regulation of beta-galactoside alpha 2,6-sialyltransferase gene expression by dexamethasone. J Biol Chem 264:1854-1859, 1989
29. Leelavathi DE, Estes LW, Feingold DS. et al: Isolation of a Golgi-rich fraction from rat liver. Biochim Biophys Acta 211 124-138, 1970
30. 125I-containing acylating agent. Biochem J 133:529-539, 1973
31. Brown MS, Goldstein JL: Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Proc Natl Acad Sci USA 71:788-792, 1974
32. Gidez LI, Miller GJ, Burstein M, et al: Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure. J Lipid Res 23:1206-1220, 1982
33. Wisniewski T, Golabek A, Matsubara E, et al: Apolipoprotein E: Binding to soluble Alzheimer's beta-amyloid. Biochem Biophys Res Commun 192:359-365, 1993
34. Hammad SM, Ranganathan S, Loukinova E, et al: Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J Biol Chem 272:18644-18649, 1997
35. Matz CE, Jonas A: Micellar complexes of human apolipoprotein A-I with phosphatidylchohnes and cholesterol prepared from cholatelipid dispersions. J Biol Chem 257:4535-4550, 1982
36. Chen GC, Albers JJ: Characterization of proteoliposomes containing apoprotein A-I: A new substrate for the measurement of lecithin: cholesterol acyltransferase activity. J Lipid Res 23:680-691, 1982
37. Jonas A: Reconstitution of high-density lipoproteins. Methods Enzymol 128:553-582, 1986
38. Laccotripe M, Makrides SC, Jonas A, et al: The carboxylterminal hydrophobic residues of apolipoprotein A-I affect its rate of phospholipid binding and its association with high density hpoprotein. J Biol Chem 272:17511-17522, 1997
39. Forte TM, Nordhausen RW: Electron microscopy of negatively stained lipoproteins. Methods Enzymol 128:442-457, 1986
40. Lerch PG, Förtsch V, Hodler G, et al: Production and characterization of a reconstituted high density lipoprotein for therapeutic applications. Vox Sang 71:155-164, 1996
41. Nichols AV, Gong EL, Blanche PJ, et al: Characterization of discoidal complexes of phosphatidylcholine, apolipoprotein AI and cholesterol by gradiant gel electrophoresis. Biochim Biophys Acta 750:353-364, 1983
42. Gillotte KL, Davidson WS, Lund-Katz S, et al: Apolipoprotein A-I structural modification and the functionality of reconstituted high density lipoprotein particles in cellular cholesterol efflux. J Biol Chem 271:23792-23798, 1996
43. Mills GL, Taylaur CE: The distribution and composition of serum lipoproteins in eighteen animals. Comp Biochem Physiol B Biochem Mol Biol 40:489-501, 1971
44. Chapman J: Comparative analysis of mammalian plasma lipoproteins. Methods Enzymol 128:70-143, 1986
45. Soutar AK, Myant NB: Plasma lipoproteins, in Offord RE (ed): Chemistry of Macromolecules IIB - Macromolecular Complexes, vol 25. Baltimore, MD. University Park, 1979, pp 55-119
46. Aggerbeck LP, Wetterau JR, Weisgraber KH, et al: Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains. J Biochem 263:6249-6258, 1988
47. Dergunov AD, Shuvaev VV, Yanushevskaja EV: Quaternary structure of apolipoprotein E in solution: Fluorimetric, chromatographic and immunochemical studies. Biol Chem Hoppe Seyler 373:323-331, 1992
48. Banka CL, Black AS, Cutiss LK: Localization of an apolipoprotein A-I epitope critical for lipoprotein-mediated cholesterol efflux from monocytic cells. J Biol Chem 269:10288-10297, 1994
49. Rail SCJ, Weisgraber KH, Mahley RW: Human apolipoprotein E: The complete amino acid sequence. J Biol Chem 257:4171-4178, 1982
50. McLean JW, Elshourbagy NA, Chang DJ, et al: Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant. J Biol Chem 259:6498-6504, 1984
51. McLean JW, Fukazawa C, Taylor JM: Rat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNA. J Biol Chem 258:8993-9000, 1983
52. Reardon CA, Hay RV, Gordon JI, et al: Processing of rat liver apoprotein E primary translation product. J Lipid Res 25:348-360, 1984
53. Ghosh P, Liu QH, Lakshman MR: Long-term ethanol exposure impairs glycosylation of both N- and O-glycosylated proteins in rat liver. Metabolism 44:890-898, 1995
54. Rao MN, Lakshman MR: Chronic ethanol downregulates galbeta-1,4glcnac alpha2,6-sialyltransferase and gal-beta-1,Sglcnac alpha2,3-sialyltransferase mRNAs in rat liver. Alcohol Clin Exp Res 21:348-351, 1997
55. Baraona E, Lieber CS: Effects of chronic ethanol feeding on serum lipoprotein metabolism in the rat. J Clin Invest 49:769-778, 1970
56. Lakshman MR, Chirtel SJ, Chambers LC, et al: Hepatic synthesis of apoproteins of very low density and high density lipoproteins in perfused rat liver: Influence of heavy and moderate doses of ethanol. Alcohol Clin Exp Res 13:554-559, 1989
57. Ashwell G, Harford J: Carbohydrate-specific receptors of the liver. Annu Rev Biochem 51:531-554, 1982
58. Sly SW: The phosphomannosyl recognition system for intracellular and intercellular transport of lysosomal enzymes, in Horowitz MI (ed): The Glycoconjugates, vol 4. New York, NY, Academic, 1982, pp 3-25
59. Reitman ML, Kornfeld S: UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosacchande units of lysosomal enzymes. J Biol Chem 256:4275-4281, 1981
60. Kalyan NK, Bahl OP: Role of carbohydrate in human chorionic gonadotropin. Effect of deglycosylation on the subunit interaction and on its in vitro and in vivo biological properties. J Biol Chem 258:67-74, 1983
61. Chavin SI, Weidner SM: Blood clotting factor IX. Loss of activity after cleavage of sialic acid residues. J Biol Chem 259:3387-3390, 1984
62. Sheker LJ, Lane MD: Post-translational processing of the epidermal growth factor receptor. Glycosylation-dependent acquisition of ligand-binding capacity. J Biol Chem 260:687-690, 1985
63. Yamaguchi K, Akai K, Kawanishi G, et al: Effects of sitedirected removal of N-glycosylation sites in human erythropoietin on its production and biological properties. J Biol Chem 266:20434-20439, 1991
64. Arnold E, Tanner W: An obligatory role of protein glycosylation in the life cycle of yeast cells. FEBS Lett 148:49-53, 1982
65. Savage KE, Baur PS: Effect of tunicamycin, an inhibitor of protein glycosylation, on division of tumour cells in vitro. J Cell Sci 64:295-306, 1983
66. Klebl F, Huffaker T, Tanner W: A temperature-sensitive N-glycosylation mutant of S. cerevisiae that behaves like a cell-cycle mutant. Exp Cell Res 150:309-313, 1984
67. Yoshimura A, Yoshida T, Seguchi T, et al: Low binding capacity and altered O-linked glycosylation of low density lipoprotein receptor in a monensin-resistant mutant of Chinese hamster ovary cells. J Biol Chem 262:13299-13308, 1987
68. Remaley AT, Wong AW, Schumacher UK, et al: O-linked glycosylation modifies the association of apolipoprotein A-II to high density lipoprotein. J Biol Chem 268:6785-6790, 1993