Fragrance material review on alpha-terpineol

Food and Chemical Toxicology

Volumn 46, Issue 11 SUPPL., 2008, Pages

  Bhatia, S P ^a   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

alpha Terpineol; Fragrance material; Review

Indexed keywords

FRAGRANCE; TERPINEOL;

AMES TEST; ARTICLE; BIOTRANSFORMATION; BLOOD LEVEL; CARCINOGENICITY; GLUCURONIDATION; HUMAN; METABOLISM; MUTAGENICITY; NONHUMAN; PATCH TEST; SAFETY; SKIN IRRITATION; SKIN TOXICITY; TISSUE LEVEL; TOXICITY TESTING; URINARY EXCRETION;

ANIMALS; CYCLOHEXENES; DRUG ADMINISTRATION ROUTES; GUINEA PIGS; HUMANS; MICE; MOLECULAR STRUCTURE; MONOTERPENES; MUTAGENICITY TESTS; PERFUME; RABBITS; RATS;

EID: 55649099824     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.06.027     Document Type: Article

References (36)

1. Ames B.N., McCann J., and Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutation Research 31 (1975) 347-363
2. Basketter D.A., York M., McFadden J.P., and Robinson M.K. Determination of skin irritation potential in the human 4-h patch test. Contact Dermatitis 51 (2004) 1-4
3. Belsito D., Bickers D., Bruze M., Greim H., Hanifin J.H., Rogers A.E., Saurat J.H., Sipes I.G., Calow P., and Tagami H. A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients. Food and Chemical Toxicology 46 11S (2008) S1-S71
4. Buchbauer G., Jirovetz L., Jager W., Plank C., and Dietrich H. Fragrance compounds and essential oils with sedative effects upon inhalation. Journal of Pharmaceutical Science 82 (1993) 660-664
5. Council of Europe, 2000. Partial agreement in the social and public health field. Chemically-defined flavouring substances. Group 2.1.5 Cyclic terpene alcohols, p.66, number 62. Council of Europe Publishing, Strasbourg.
6. Flavor and Extract Manufacturers Association, 1965. Recent progress in the consideration of flavoring ingredients under the food additives amendment III. GRAS substances. Food Technology 19, 151-197.
7. Florin I., Rutberg L., Curvall M., and Enzell C.R. Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology 18 (1980) 219-232
8. Food and Drug Administration. Code of Federal Regulations, 21 CFR 172.515. Title 21 - Food and Drugs, vol. 3, Chapter I - Food and Drug Administration, Department of Health and Human Services. Part 172 - Food Additives Permitted for Direct Addition to Food for Human Consumption. Subpart F - Flavoring Agents and Related Substances, 515 - Synthetic Flavoring Substances and Adjuvants.
9. Frosch P.J., Johansen J.D., Menne T., Pirker C., Rastogi S.C., Andersen K.E., Bruze M., Goossens A., Lepoittevin J.P., and White I.R. Further important sensitizers in patients sensitive to fragrances. II. Reactivity to essential oils. Contact Dermatitis 47 (2002) 279-287
10. Green M.D., and Tephly T.R. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein. Drug Metabolism and Disposition 24 (1996) 356-363
11. Hausen B.M., Reichling J., and Harkenthal M. Degradation products of monoterpenes are the sensitizing agents in tea tree oil. American Journal of Contact Dermatitis 10 (1999) 68-77
12. Heck J.D., Vollmuth T.A., Cifone M.A., Jagannath D.R., Myhr B., and Curren R.D. An evaluation of food flavoring ingredients in a genetic toxicity screening battery. The Toxicologist 9 (1989) 257
13. Hill R.M., Barer J., Hill L.L., Butler C.M., Harvey D.J., and Horning M.G. An investigation of recurrent pine oil poisoning in an infant by the use of gas chromatographic-mass spectrometric methods. Journal of Pediatrics 87 (1975) 115-118
14. IFRA (International Fragrance Association), 2004. Use Level Survey, September 2004.
15. Ishida T., Asakawa Y., Takemoto T., and Aratani T. Terpenoids biotransformation in mammals III: Biotransformation of alpha-pinene, beta-pinene, pinane, 3-carene, carane, myracene, and p-cymene in rabbits. Journal of Pharmaceutical Sciences 70 (1981) 406-415
16. Imaizumi K., Hanada K., Mawatari K., and Sugano M. Effect of essential oils on the concentration of serum lipids and apolipoproteins in rats. Agricultural and Biological Chemistry 49 (1985) 2795-2796
17. Ishihara M., Itoh M., Nishimura M., Kinoshita M., Kantoh H., Nogami T., and Yamada K. Closed epicutaneous test. Skin Research 28 (1986) 230-240
18. Joint Expert Committee on Food Additives, 1999. Safety evaluation of certain food additives. Who Food Additives Series: 42. Prepared by the Fifty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). World Health Organization, Geneva 2000.
19. Jirovetz L., Buchbauer G., Jager W., Woidich A., and Nikiforov A. Analysis of fragrance compounds in blood samples of mice by gas chromatography, mass spectrometry, GC/FTIR and GC/AES after inhalation of sandalwood oil. Biomedical Chromatography 6 (1992) 133-134
20. Kitahara M., Ishiguro F., Takayama K., Isowa K., and Nagai T. Evaluation of skin damage of cyclic monoterpenes, percutaneous absorption enhancers, by using cultured human skin cells. Biological and Pharmaceutical Bulletin 16 (1993) 912-916
21. Lehman-McKeeman L.D., and Caudill D. Development of an in vitro competitive binding assay to predict alpha2u-globulin nephropathy. In Vitro and Molecular Toxicology 12 (1999) 83-95
22. Madyastha K.M., and Srivatsan V. Biotransformation of alpha-terpineol in the rat: its effects on the liver microsomal cytochrome p-450 system. Bulletin of Environmental Contamination and Toxicology 41 (1988) 17-25
23. Magnusson B., and Kligman A.M. The identification of contact allergens by animal assay. The guinea pig maximization test. The Journal of Investigative Dermatology 52 (1969) 268-276
24. Northover B.J., and Verghese J. The pharmacology of certain terpene alcohols and oxides. Journal of Scientific and Industrial Research 21C (1962) 342-345
25. RIFM (Research Institute for Fragrance Materials Inc.), 1982. Mutagenicity Evaluation of alpha-Terpineol in the Mouse Lymphoma Forward Mutation Assay, June 1982.
26. RIFM (Research Institute for Fragrance Materials Inc.), 1983. Mutagenicity Evaluation of alpha-Terpineol in the Ames Salmonella/Microsome Plate Test, July 1983.
27. RIFM (Research Institute for Fragrance Materials Inc.), 1984a. 14-Day single dose subacute toxicity study with alpha-Terpineol, 1 August, 1984.
28. RIFM (Research Institute for Fragrance Materials Inc.), 1984b. Acute dermal irritation study in rabbits. RIFM report number 1795. RIFM, Woodcliff Lake, NJ, USA.
29. RIFM (Research Institute for Fragrance Materials Inc.), 1985. Acute dermal irritation study in rabbits. RIFM report number 3099. RIFM, Woodcliff Lake, NJ, USA.
30. RIFM (Research Institute for Fragrance Materials Inc.), 1986. Acute dermal irritation study in rabbits. RIFM report number 5664. RIFM, Woodcliff Lake, NJ, USA.
31. Saeed A.M., and Sabir A.W. Studies on the contact dermatitic properties of Pakistani medicinal plants Part VI. Dermal irritating properties of Lavandula stoechas L. Marmara Universityesi Eczacilik Dergisi 10 (1994) 39-49
32. Santucci B., Cristaudo A., Cannistraci C., and Picardo M. Contact dermatitis to fragrances. Contact Dermatitis 16 (1987) 93-95
33. Stoner G.D., Shimkin M.B., Kniazeff A.J., Weisburger J.H., Weisburger E.K., and Go G.B. Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice. Cancer Research 33 (1973) 3069-3085
34. Tobin T., Swerczek T.W., and Blake J.W. Pine oil toxicity in the horse: drug detection, residues and pathological changes. Research Communications in Chemical Pathology and Pharmacology 15 (1976) 291-301
35. Wright S.E. Detoxication mechanisms in the sheep. University Queensland Papers 1 25-26 (1945) 1-10
36. Yamahara J., Kimura H., Kobayashi M., Okamoto T., Sawada T., Fujimura H., and Chisaka T. Cholagogic action and characteristics of (+/-)-alpha-terpineol-beta-d-O-glucopyranoside, a new monoterpenoid glucoside. Chemical and Pharmaceutical Bulletin 33 (1985) 1669-1675