Characterization of demethylation of methylmercury in cultured astrocytes

Chemosphere

Volumn 74, Issue 1, 2008, Pages 112-118

  Shapiro, Aaron M ^a   Chan, Hing Man ^a  

^a UNIVERSITY OF NORTHERN BRITISH COLUMBIA   (Canada)

Author keywords

Astrocytes; Brain; Demethylation; Inorganic mercury toxicity; Methylmercury

Indexed keywords

MAGNESIUM PRINTING PLATES; MERCURY COMPOUNDS; OXYGEN; TOXICITY;

ASTROCYTES; CENTRAL NERVOUS SYSTEMS; CULTURE MODELS; DEMETHYLATION; IN VITRO; IN VITRO MODELS; INORGANIC MERCURY TOXICITY; METHYL MERCURIES; METHYLMERCURY; NEONATAL RATS; REACTIVE OXYGEN SPECIES;

MERCURY (METAL);

BUTHIONINE SULFOXIMINE; FLUORESCEIN; METHYLMERCURY; REACTIVE OXYGEN METABOLITE; ROTENONE;

BIOACCUMULATION; BRAIN; METHYLMERCURY; NERVOUS SYSTEM; RODENT; TOXICITY;

ANIMAL CELL; ARTICLE; ASTROCYTE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEMETHYLATION; IN VITRO STUDY; NERVE CELL CULTURE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BUTHIONINE SULFOXIMINE; CELLS, CULTURED; METHYLATION; METHYLMERCURY COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; ROTENONE;

RATTUS;

EID: 55649091826     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2008.09.019     Document Type: Article

References (46)

1. Allen J.W., Mutkus L.A., and Aschner M. Mercuric chloride, but not methylmercury, inhibits glutamine synthetase activity in primary cultures of cortical astrocytes. Brain Res. 891 (2001) 148-157
2. Allen J.W., Shanker G., Tan K.H., and Aschner M. The consequences of methylmercury exposure on interactive functions between astrocytes and neurons. Neurotoxicology 23 (2002) 755-759
3. Almeida A., and Medina J.M. Isolation and characterization of tightly coupled mitochondria from neurons and astrocytes in primary culture. Brain Res. 764 (1997) 167-172
4. Aramaki R., Yasutake A., Usuki F., and Hirayama K. Degradation of methylmercury in rat liver and cell cultures. Neurotoxicology 25 (2004) 708
5. Aschner M., and Aschner J.L. Mercury neurotoxicity: mechanisms of blood-brain barrier transport. Neurosci. Biobehav. Rev. 14 (1990) 169-176
6. Aschner M., Syversen T., Souza D.O., Rocha J.B., and Farina M. Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz. J. Med. Biol. Res. 40 (2007) 285-291
7. Basu N., Stamler C.J., Loua K.M., and Chan H.M. An interspecies comparison of mercury inhibition on muscarinic acetylcholine receptor binding in the cerebral cortex and cerebellum. Toxicol. Appl. Pharm. 205 (2005) 71-76
8. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
9. Burbacher T.M., Shen D.D., Liberato N., Grant K.S., Cernichiari E., and Clarkson T. Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. Environ. Health Persp. 113 (2005) 1015-1021
10. Callum G.I., Ferguson M.M., and Lenihan J.M. Determination of methylmercury in tissue using enzyme proteolysis. Analyst 106 (1981) 1009-1013
11. Carrier G., Bouchard M., Brunet R.C., and Caza M. A toxicokinetic model for predicting the tissue distribution and elimination of organic and inorganic mercury following exposure to methyl mercury in animals and humans. II. Application and validation of the model in humans. Toxicol. Appl. Pharm. 171 (2001) 50-60
12. Castoldi A.F., Candura S.M., Costa P., Manzo L., and Costa L.G. Interaction of mercury compounds with muscarinic receptor subtypes in the rat brain. Neurotoxicology 17 (1996) 735-741
13. Celo V., Lean D.R., and Scott S.L. Abiotic methylation of mercury in the aquatic environment. Sci. Total Environ. 368 (2006) 126-137
14. Charleston J.S., Body R.L., Mottet N.K., Vahter M.E., and Burbacher T.M. Autometallographic determination of inorganic mercury distribution in the cortex of the calcarine sulcus of the monkey Macaca fascicularis following long-term subclinical exposure to methylmercury and mercuric-chloride. Toxicol. Appl. Pharm. 132 (1995) 325-333
15. Charleston J.S., Body R.L., Bolender R.P., Mottet N.K., Vahter M.E., and Burbacher T.M. Changes in the number of astrocytes and microglia in the thalamus of the monkey Macaca fascicularis following long-term subclinical methylmercury exposure. Neurotoxicology 17 (1996) 127-138
16. Chen J., Small-Howard A., Yin A., and Berry M.J. The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO). BMC Neurosci. 6 (2005)
17. Compeau G.C., and Bartha R. Sulfate-reducing bacteria: principal methylators of mercury in anoxic estuarine sediment. Appl. Environ. Microb. 50 (1985) 498-502
18. Compton S.J., and Jones C.G. Mechanism of dye response and interference in the Bradford protein assay. Anal. Biochem. 151 (1985) 369-374
19. Friberg L., and Mottet N.K. Accumulation of methylmercury and inorganic mercury in the brain. Biol. Trace Elem. Res. 21 (1989) 201-206
20. Gardfeldt K., Sommar J., Stromberg D., and Feng X. Oxidation of atomic mercury by hydroxyl radicals and photoinduced decomposition of methylmercury in the aqueous phase. Atmos. Environ. 35 (2001) 3039-3047
21. Garman R.H., Weiss B., and Evans H.L. Alkylmercurial encephalopathy in the monkey (Saimiri sciureus and Macaca arctoides). Acta Neuropathol. 32 (1975) 61-74
22. Gasso S., Cristofol R.M., Selema G., Rosa R., Rodriguez-Farre E., and Sanfeliu C. Antioxidant compounds and Ca(2+) pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity. J. Neurosci. Res. 66 (2001) 135-145
23. Griffith O.W. Mechanism of Action, Metabolism, and Toxicity of Buthionine Sulfoximine and Its Higher Homologs, Potent Inhibitors of Glutathione Synthesis. J. Biol. Chem. 257 (1982) 3704-3712
24. Hirayama K., and Yasutake A. Effects of reactive oxygen modulators on in vivo demethylation of methylmercury. Jpn J. Tox. Env. Health 45 (1999) 24-27
25. Hoffmeyer R.E., Singh S.P., Doonan C.J., Ross A.R.S., Hughes R.J., Pickering I.J., and George G.N. Molecular Mimicry in Mercury Toxicology. Chem. Res. Toxicol. 19 (2006) 753-759
26. Jack C.S., Arbour N., Manusow J., Montgrain V., Blain M., McCrea E., Shapiro A., and Antel J.P. TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes. J. Immunol. 175 (2005) 4320-4330
27. Jacobson J., Duchen M.R., Hothersall J., Clark J.B., and Heales S.J.R. Induction of mitochondrial oxidative stress in astrocytes by nitric oxide precedes disruption of energy metabolism. J. Neurochem. 95 (2005) 388-395
28. Klebl B.M., Ayoub A.T., and Pette D. Protein oxidation, tyrosine nitration, and inactivation of sarcoplasmic reticulum Ca2+-ATPase in low-frequency stimulated rabbit muscle. FEBS Lett. 422 (1998) 381-384
29. Leistevuo J., Leistevuo T., Helenius H., Pyy L., Osterblad M., Huovinen P., and Tenovuo J. Dental amalgam fillings and the amount of organic mercury in human saliva. Caries Res. 35 (2001) 163-166
30. Monnet-Tschudi F., Zurich M.G., and Honegger P. Comparison of the developmental effects of two mercury compounds on glial cells and neurons in aggregate cultures of rat telencephalon. Brain Res. 741 (1996) 52-59
31. Muyderman H., Nilsson M., and Sims N.R. Highly Selective and Prolonged Depletion of Mitochondrial Glutathione in Astrocytes Markedly Increases Sensitivity to Peroxynitrite. J. Neurosci. 24 (2004) 8019-8028
32. NRC (National Research Council), 2000. Toxicological Effects of Methylmercury. National Academy Press, Washington, D.C.
33. Pamphlett R., and Waley P. Motor neuron uptake of low dose inorganic mercury. J. Neurol. Sci. 135 (1996) 63-67
34. Rowland I.R., Davies M.J., and Evans J.G. Tissue content of mercury in rats given methylmercuric chloride orally: influence of intestinal flora. Arch. Environ. Health 35 (1980) 155-160
35. Sherer T.B., Betarbet R., Testa C.M., Seo B.B., Richardson J.R., Kim J.H., Miller G.W., Yagi T., Matsuno-Yagi A., and Greenamyre J.T. Mechanism of Toxicity in Rotenone Models of Parkinson's Disease. J. Neurosci. 23 (2003) 10756-10764
36. Siciliano S.D., and Lean D.R. Methyltransferase: an enzyme assay for microbial methylmercury formation in acidic soils and sediments. Environ. Toxicol. Chem. 21 (2002) 1184-1190
37. Siciliano S.D., O'Driscoll N.J., Tordon R., Hill J., Beauchamp S., and Lean D.R. Abiotic production of methylmercury by solar radiation. Environ. Sci. Technol. 39 (2005) 1071-1077
38. Suda I., and Hirayama K. Degradation of methyl and ethyl mercury into inorganic mercury by hydroxyl radical produced from rat liver microsomes. Arch. Toxicol. 66 (1992) 398-402
39. Syversen T., Aschner M., and Sonnewald U. Effect of methylmercury on glutamate metabolism in cerebellar astrocytes in culture. Neurochem. Int. 43 (2003) 411-416
40. Syversen,T., Kummeneje,E., Aschner,M. 2006. Demethylation of methylmercury in primary cultures of cerebellar neurons and astrocytes. Society of Toxicology Annual Meeting, 423.
41. Tang N., and Li Y.M. Neurotoxic effects in workers of the clinical thermometer manufacture plant. Int. J. Occup. Med. Environ. Health 19 (2006) 198-202
42. U.S.EPA., 1997. Mercury Study Report to Congress. Volume V: Health Effects of Mercury and Mercury Compounds. Office of Research and Development, Washington DC.
43. Vahter M.E., Mottet N.K., Friberg L.T., Lind S.B., Charleston J.S., and Burbacher T.M. Demethylation of methyl mercury in different brain sites of Macaca fascicularis monkeys during long-term subclinical methyl mercury exposure. Toxicol. Appl. Pharm. 134 (1995) 273-284
44. Yasutake A., and Hirayama K. Evaluation of methylmercury biotransformation using rat liver slices. Arch. Toxicol. 75 (2001) 400-406
45. Yee S., and Choi B.H. Oxidative stress in neurotoxic effects of methylmercury poisoning. Neurotoxicology 17 (1996) 17-26
46. Zeevalk G.D., Bernard L.P., Song C., Gluck M., and Ehrhart J. Mitochondrial inhibition and oxidative stress: reciprocating players in neurodegeneration. Antioxid. Redox Sig. 7 (2005) 1117-1139