Genetic effects of blood pressure quantitative trait loci on hypertension-related organ damage: Evaluation using multiple congenic strains

Hypertension Research

Volumn 31, Issue 9, 2008, Pages 1773-1779

  Ishikawa, Noriyoshi ^a   Harada, Yuji ^a   Maruyama, Riruke ^a   Masuda, Junichi ^a   Nabika, Toru ^a  

^a SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

Cerebral stroke; Congenic rats; Glomerulosclerosis; Quantitative trait loci; Stroke prone spontaneously hypertensive rat

Indexed keywords

ALBUMIN; SODIUM CHLORIDE;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CEREBROVASCULAR ACCIDENT; CHROMOSOME 1; CONGENIC STRAIN; CONTROLLED STUDY; DISEASE SEVERITY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GLOMERULOSCLEROSIS; HISTOPATHOLOGY; HYPERTENSION; KIDNEY DISEASE; MALE; NONHUMAN; ORGAN INJURY; QUANTITATIVE TRAIT LOCUS; RAT; SALT LOADING; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

EID: 55549145098     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1291/hypres.31.1773     Document Type: Article

References (22)

1. Okamoto K, Yamori Y, Nagaoka A: Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res 1974; 34/38 (Suppl I): I-143-I-153.
2. Gigante B, Rubattu S, Stanzione R, et al: Contribution of genetic factors to renal lesions in the stroke-prone spontaneously hypertension rat. Hypertension 2003; 42: 702-706.
3. Griffin KA, Churchil PC, Picken M, Webb RC, Kurtz TW, Bidani AK: Differential salt-sensitivity in the pathogenesis of renel damage in SHR and stroke prone SHR. Am J Hypertens 2001; 14: 311-320.
4. Mashimo T, Nabika T, Matsumoto C, et al: Aging and salt-loading modulate blood pressure QTLs in rats. Am J Hypertens 1999; 12: 1098-1104.
5. Kato N, Mashimo T, Nabika T, Cui ZH, Ikeda K, Yamori Y: Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony. J Hypertens 2003; 21: 295-303.
6. Kato N, Nabika T, Liang Y-Q, et al: Isolation of a chromosome 1 region affecting blood pressure and vascular disease traits in the stroke-prone rat model. Hypertension 2003; 42: 1191-1197.
7. Schulz A, Litfin A, Kossmehl P, Kreutz R: Genetic dissection of increased urinary albumin excretion in the Munich Wistar Fromter rat. J Am Soc Nephrol 2002; 13: 2706-2714.
8. Siegel A-K, Kossmehl P, Planert M, et al: Genetic linkage of albuminuria and renal injury Dahl salt-sensitive rats on a high-salt diet: comparison with spontaneously hypertensive rats. Physiol Genomics 2004; 18: 218-225.
9. Yagil C, Sapojnikov M, Katni G, et al: Proteinuria and glomerulosclerosis in the Sabra genetic rat model of salt susceptibility. Physiol Genomics 2002; 9: 167-178.
10. Kortanje R, DiPetrillo K: Unraveling the genetics of chronic kidney disease using animal models. Am J Physiol 2004; 287: F347-F352.
11. Rubattu S, Volpe M, Kreutz R, Ganten U, Ganten D, Lindpaintner K: Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease. Nat Genet 1996; 13: 429-434.
12. Garrett MR, Dene H, Walder R, et al: Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Genome Res 1998; 8: 711-713.
13. Saad Y, Garrett MR, Lee SJ, Dene H, Rapp JP: Localization of a blood pressure QTL on rat chromosome 1 using Dahl rat congenic strains. Physiol Genomics 1999; 1: 119-125.
14. Rubattu S, Hubner N, Ganten U, et al: Reciprocal congenic lines for a major stroke QTL on rat chromosome 1. Physiol Genomics 2006; 27: 108-113.
15. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ: Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet 1996; 12: 44-51.
16. Yao H, Cui ZH, Masuda J, Nabika T: Congenic removal of a QTL for blood pressure attenuates infarct size produced by middle cerebral artery occlusion in hypertensive rats. Physiol Genomics 2007; 30: 69-73.
17. Cui ZH, Nemoto K, Kawakami K, Gonda T, Nabika T, Masuda J: Fine linkage mapping of the blood pressure quantitative trait locus region on rat chromosome 1. Hypertens Res 2002; 25: 605-608.
18. Guyton AC, Hall JE: Urine formation by the kidneys: I. Glomerular filtration, renal blood flow, and their control, in Textbook of Medical Physiology. Philadelphia, Saunders Co, 1996, pp 315-330.
19. Rangel-Filho A, Sharma M, Datta YH, et al: Rf-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the Fawn-Hooded hypertensive rat. J Am Soc Nephrol 2005; 16: 852-856.
20. Ois N, Riddle SR, Serikawa T, Kuramoto T, Spritz RA: The rat Ruby (R) locus is Rab38: identical mutations in Fawnhooded and Tester-Moriyama rats derived from an ancestral long Evans rat sub-strain. Mamm Genome 2004; 15: 307-314.
21. Kuwahara M, Sugano S, Yayou K, Tsubone H, Kobayashi H: Evaluation of a new tail-cuff method for blood pressure measurement in rats with special reference ot the effects of ambient temperature. Exp Anim 1991; 40: 331-336.
22. St Lezin E, Griffin KA, Picken M, et al: Genetic isolation of a chromosome 1 region affecting susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat. Hypertension 1999; 34: 187-191.