Histopathological and biochemical changes following fat embolism with administration of corn oil micelles: A new animal model for fat embolism syndrome

Journal of Bone and Joint Surgery - Series B

Volumn 90, Issue 11, 2008, Pages 1517-1521

  Liu, D D ^a,b   Hsieh, N K ^a,c   Chen, H I ^a,d  

^a Center for Neuropsychiatry   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c TAO YUAN GENERAL HOSPITAL   (Taiwan)

^d TZU CHI UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CORN OIL; CYTOKINE; FAT DROPLET; METHYLGUIDANIDINE; NITRATE; NITRITE; OLEIC ACID; PHOSPHOLIPASE A2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CHEMICAL ANALYSIS; CONTROLLED STUDY; EXPERIMENTAL MODEL; FAT EMBOLISM; HISTOPATHOLOGY; HYPERCAPNIA; HYPOXIA; KIDNEY; LIPID STORAGE; LUNG; LUNG EDEMA; LUNG HEMORRHAGE; LUNG WEIGHT; MALE; MASS SPECTROMETRY; MICELLE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; CORN OIL; DIETARY FATS, UNSATURATED; DISEASE MODELS, ANIMAL; EMBOLISM, FAT; FRACTURES, BONE; KIDNEY; LUNG; MALE; MICELLES; RATS; RATS, SPRAGUE-DAWLEY; SYNDROME;

EID: 55549137710     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.90B11.20761     Document Type: Article

References (39)

1. Karagiorga G, Nakos G, Galiatsou E, Lekka ME. Biochemical parameters of brochoalveolar lavage fluid in fat embolism. Intensive Care Med 2006;32:116-23.
2. Mellor A, Soni N. Fat embolism. Anaesthesia 2001;56:145-54.
3. Habashi NM, Andrews PL, Scalea TM. Therapeutic aspects of fat embolism syndrome. Injury 2006;37(4 suppl):68-73.
4. Giannoudis PV, Tzioupis C, Pape HC. Fat embolism: the reaming controversy. Injury 2006;37(4 suppl):50-8.
5. Riding G, Daly K, Hutchinson S. Paradoxical cerebral embolisation: an explanation for fat embolism syndrome. J Bone Joint Surg [Br] 2004;86-B:95-8.
6. Talbot M, Schemitsch EH. Fat embolism syndrome: history, definition, epidemiology. Injury 2006;37(4 suppl):3-7.
7. Hsu YH, Kao SJ, Lee RP, Chen HI. Acute pulmonary oedema: rare causes and possible mechanisms. Clin Sci (Lond) 2003;104:259-64.
8. Kao SJ, Yeh DY, Chen HI. Clinical and pathological features of fat embolism with acute respiratory distress syndrome. Clin Sci (Lond) 2007;113:279-85.
9. Kontakis GM, Tossounidis T, Weiss K, Pape HC, Giannoudis PV. Fat embolism: special situations: bilateral femoral fractures and pathologic femoral fractures. Injury 2006;37:19-24.
10. Peltier LF. Fat embolism: a current concept. Clin Orthop 1969;66:241-53.
11. Peltier LF. Fat embolism: a perspective. Clin Orthop 1988;232:263-70.
12. Nakata Y, Tanaka H, Kuwagata Y, Yoshioka T, Sugimoto H. Triolein-induced pulmonary embolization and increased microvascular permeability in isolated perfused rat lungs. J Trauma 1999;47:111-19.
13. Rae D, Porter J, Beechey-Newman N, et al. Type 1 prophospholipase A2 propeptide in acute lung injury. Lancet 1994;344:1472-3.
14. Fukui K, Kominami R, Shinohara H, Matsumoto T. Glucocorticoid induces microfat embolism in the rabbit: a scanning electron microscopic study. J Orthop Res 2006;24:675-83.
15. Aebli N, Schwenke D, Davis G. Polymethylmethacrylate causes prolonged pulmonary hypertension during fat embolism: a study in sheep. Acta Orthop 2005;76:904-11.
16. Buttaro M, Mocetti E, Alfie V, Paniego G, Piñeiro L. Fat embolism and related effects during reamed and unreamed intramedullary nailing in a pig model. J Orthop Trauma 2002;16:239-44.
17. Schemitsch EH, Jain R, Turchin DC, et al. Pulmonary effects of fixation of a fracture with a plate compared with intramedullary nailing: a canine model of fat embolism and fracture fixation. J Bone Joint Surg [Am] 1997;79-A:984-96.
18. Kim HJ, Lee CH, Kim HG, et al. Reversible MR changes in the cat brain after cerebral fat embolism induced by triolein emulsion. AJNR Am J Neuroradiol 2004;25:958-63.
19. Kim HJ, Lee JH, Lee CH, et al. Experimental cerebral fat embolism: embolic effects of triolein and oleic acid depicted by MR imaging and electron microscopy. AJNR Am J Neuroradiol 2002;23:1516-23.
20. Young JS, Rayhrer CS, Edmisten TD, et al. Sodium nitroprusside mitigates oleic acid-induced acute lung injury. Ann Thorac Surg 2000;69:224-7.
21. Chen HI, Yeh DY, Liou HL, Kao SJ. Insulin attenuates endotoxin-induced acute lung injury in conscious rats. Crit Care Med 2006;34:758-64.
22. Tracy RE, Walia P. A method to fix lipids for staining fat embolism in paraffin sections. Histopathology 2002;41:75-9.
23. Kitsiouli EI, Nakos G, Lekka ME. Differential determination of phospholipase A(2) and PAF-acetylhydrolase in biological fluids using fluorescent substrates. J Lipid Res 1999;40:2346-56.
24. Hsu BG, Lee RP, Yang FL, Harn HJ, Chen HI. Post-treatment with N-acetylcysteine ameliorates endotxin shock-induced organ damage in conscious rats. Life Sci 2006;79:2010-16.
25. Muscará MN, de Nucci G. Simultaneous determination of nitrite and nitrate anions in plasma, urine and cell culture supernatants by high-performance liquid chromatography with post-column reactions. J Chromatogr B Biomet Appl 1996;686:157-64.
26. Otano A, García-Osta A, Ballaz S, Frechilla D, DelRió J. Facilitation by 8-O-HDPAT of passive avoidance performance in rats after inactivation of 5-HT (1A) receptors. Br J Pharmacol 1999;128:1691-8.
27. Roger N, Xaubert A, Agusti C, et al. Role of bronchoalveolar lavage in the diagnosis of fat embolism syndrome. Eur Respair J 1995;8:1275-80.
28. White T, Petrisor BA, Bhandari M. Prevention of fat embolism syndrome. Injury 2006;37:59-67.
29. Gurd AR. Fat embolism: an aid to diagnosis. J Bone Joint Surg [Br] 1970;52-B:732-7.
30. Gurd AR, Wilson RI. The fat embolism syndrome. J Bone Joint Surg [Br] 1974;56-B:408-16.
31. Kamenar E, Burger PC. Cerebral fat embolism: a neuropathophysiological study of a microembolic state. Stroke 1980;11:477-84.
32. Kim HJ, Lee CH, Lee SH, Moon TY. Magnetic resonance imaging and histologic findings of experimental cerebral fat embolism. Invest Radiol 2003;38:625-34.
33. Parizel PM, Demey HE, Veeckmans G, et al. Early diagnosis of cerebral fat embolism syndrome by diffusion-weighted MRI (starfield pattern). Stroke 2001;32:2942-4.
34. Brondén B, Dencker M, Allers M, Plaza I, Jönsson H. Differential distribution of lipid microemboli after cardiac surgery. Ann Thorac Surg 2006;81:643-8.
35. Nakamura K, Ienaga K, Yokozawa T, Fujitsuka N, Oura H. Production of methylguanidine from creatinine via creatol by active oxygen species: analyses of the catabolism in vitro. Nephron 1991;58:42-6.
36. Vadász I, Morty RE, Kohstall MG, et al. Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome? Am J Respir Crit Care Med 2005;171:469-79.
37. Lim SC, Adams AB, Simonson DA, et al. Transient hemodynamic effects of recruitment maneuvers in three experimental models of acute lung injury. Crit Care Med 2004;32:2378-84.
38. Lim SC, Adams AB, Simonson DA, et al. Intercomparison of recruitment maneuver efficacy in three models of acute lung injury. Crit Care Med 2004;32:2371-7.
39. Bursten SL, Federighi DA, Parsons P, et al. An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome. Crit Care Med 1996;24:1129-36.