Effects of matrine on the growth inhibition, c-myc and hTERT protein expression in human adenocarcinoma lung cancer cell line A549

Chinese Journal of Lung Cancer

Volumn 11, Issue 4, 2008, Pages 559-562

  Chen, Qiong ^a   Liu, Lihong ^b   Cao, Hong ^c  

^a No 2 People's Hospital of Chengdu   (China)

^b Hankou Union Hospital   (China)

^c ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

hTERT; Lung neoplasms; Matrine; Telomerase

Indexed keywords

MATRINE; MYC PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL NUCLEUS; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; PROTEIN EXPRESSION; TIME;

EID: 55549134682     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: 10.3779/j.issn.1009-3419.2008.04.029     Document Type: Article

References (11)

1. Lee JC, Jong HS, Yoo CG, et al. Telomerase activity in lung cancer cell lines and tissues. Lung Cancer, 1998, 21(2): 99-103.
2. Li FE, Zhu LQ, Ye HJ, et al. Matrine-induced apoptosis and effect on telomerase activity in human gastric carcinoma cells SGC-7901. China Journal of Modern Medicine, 2005, 15(12): 1809-1812.
3. Chen WZ, Lin Y, Xie WF, et al. Regulation of telomerase activity and cell cycle by matrine in hepatoma cells in vitro. Acad J Sec Med Univ, 2002, 23(5): 498-500.
4. Li XF, Zhang SZ, Zheng S, et al. Effects of matrine on hTERT-mRNA expression and telomerase activity in K562 cells. Chin J Cancer, 2001, 20(4): 391-393.
5. Wang Y, Si WK, Li p, et al. Effects of matrine and oxymatrine on the proliferation and the apoptosis of A549 cells. Acad J Thi Med Univ, 2004, 26(9): 778-780.
6. Ulaner GA, Hu JF, Vu TH, et al. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res, 1998, 58(18): 4168-4172.
7. Lee JC, Jong HS, Yoo CG, et al. Telomerase activity in lung cancer cell lines and tissues. Lung cancer, 1998, 21(2): 99-103.
8. Greenberg RA, Hagan RCO, Deng HY, et al. Telomerase reverse transcriptase gene is a direct target of c-myc but is not functionally equivalent in cellular transformation. Oncogene, 1999, 18 (5): 1219-1226.
9. Wck M, Zubov D, Hagen G. Genomic organization and promoter characterization of the gene encoding the human T reverse trancriptase (hTERT). Gene, 1999, 232(1): 97-106.
10. Zhang LP, Jiang JK, Joe T. Expression of oncogene and protein regulating cell cycle progression and its significance in leukemia cell line by matrine. Chin J Clin Oncol, 2001, 28(5): 347-350.
11. Deng H, Deng HM, Huang F, et al. Inhibition of proliferation and influence of Proto-oncogene expression by matrine in U251 cells. Chin Pharmacol Bull, 2004, 20(8): 893-896.