-
1
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ et al. (1987) Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177-182
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
-
2
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ et al. (1989) Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244: 707-712
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
-
3
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ et al. (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344: 783-792
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
-
4
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
Marty M et al. (2005) Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group. J Clin Oncol 23: 4265-4274
-
(2005)
J Clin Oncol
, vol.23
, pp. 4265-4274
-
-
Marty, M.1
-
5
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ et al. (2005) Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 353 1659-1672
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
-
6
-
-
33845914783
-
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER-2 positive breast cancer: A randomized controlled trial
-
Smith I et al. (2007) 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER-2 positive breast cancer: A randomized controlled trial. Lancet 369: 29-36
-
(2007)
Lancet
, vol.369
, pp. 29-36
-
-
Smith, I.1
-
7
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH et al. (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353: 1673-1684
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
-
8
-
-
55549106173
-
-
Perez EA et al. (2005) NCCTG-N9831. May 2005 Update. Presented at the 41st American Society of Clinical Oncology Annual Meeting, 2005 May 13-17, Orlando, FL [http://www.asco.org/ac/ 1,10003,_12-002511-00_18-0034-00_19-005815-00_21-001,00.asp]
-
Perez EA et al. (2005) NCCTG-N9831. May 2005 Update. Presented at the 41st American Society of Clinical Oncology Annual Meeting, 2005 May 13-17, Orlando, FL [http://www.asco.org/ac/ 1,10003,_12-002511-00_18-0034-00_19-005815-00_21-001,00.asp]
-
-
-
-
9
-
-
36148961294
-
Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer
-
Perez EA et al. (2007) Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer. J Clin Oncol 25 (18 Suppl): LBA512
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Perez, E.A.1
-
10
-
-
33645720799
-
Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study [abstract #1]
-
Slamon D et al. (2005) Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study [abstract #1]. Breast Cancer Res Treat 94 (Suppl 1): S5
-
(2005)
Breast Cancer Res Treat
, vol.94
, Issue.SUPPL. 1
-
-
Slamon, D.1
-
11
-
-
33947317453
-
BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients
-
Slamon D et al. (2006) BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients. Breast Cancer Res Treat 100: S2
-
(2006)
Breast Cancer Res Treat
, vol.100
-
-
Slamon, D.1
-
12
-
-
33344478381
-
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
-
Joensuu H et al. (2006) Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 354: 809-820
-
(2006)
N Engl J Med
, vol.354
, pp. 809-820
-
-
Joensuu, H.1
-
13
-
-
0032127350
-
Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
-
Baselga J et al. (1999) Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res 59: 2825-2831
-
(1999)
Cancer Res
, vol.59
, pp. 2825-2831
-
-
Baselga, J.1
-
14
-
-
0033118889
-
Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
-
Pegram M et al. (1999) Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene 18: 2241-2251
-
(1999)
Oncogene
, vol.18
, pp. 2241-2251
-
-
Pegram, M.1
-
15
-
-
0036498781
-
Cardiac dysfunction in the trastuzumab clinical trials experience
-
Seidman A et al. (2002) Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol 20: 1215-1221
-
(2002)
J Clin Oncol
, vol.20
, pp. 1215-1221
-
-
Seidman, A.1
-
16
-
-
36849016904
-
Five year update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/ cyclophosphamide (AC)→paclitaxel (T) vs AC→T with trastuzumab (H)
-
Rastogi P et al. (2007) Five year update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/ cyclophosphamide (AC)→paclitaxel (T) vs AC→T with trastuzumab (H). J Clin Oncol 25 (18 Suppl): LBA512
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Rastogi, P.1
-
17
-
-
34548531901
-
Trastuzumab-associated cardiac adverse effects in the Herceptin Adjuvant trial
-
Suter TM et al. (2007) Trastuzumab-associated cardiac adverse effects in the Herceptin Adjuvant trial. J Clin Oncol 25: 1-8
-
(2007)
J Clin Oncol
, vol.25
, pp. 1-8
-
-
Suter, T.M.1
-
18
-
-
0033559619
-
Monoclonal antibody to HER-2/neu receptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene
-
Pietras RJ et al. (1999) Monoclonal antibody to HER-2/neu receptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res 59: 1347-1355
-
(1999)
Cancer Res
, vol.59
, pp. 1347-1355
-
-
Pietras, R.J.1
-
19
-
-
33749629577
-
Adjuvant radiotherapy and trastuzumab in stage I-IIA breast cancer: Toxicity data from North Central Cancer Treatment Group Phase III trial N9831
-
Halyard MY et al. (2006) Adjuvant radiotherapy and trastuzumab in stage I-IIA breast cancer: Toxicity data from North Central Cancer Treatment Group Phase III trial N9831. J Clin Oncol 24 (18 Suppl): LBA523
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 SUPPL.
-
-
Halyard, M.Y.1
-
20
-
-
0346017700
-
Pharmacokinetics, safety, and efficacy of trastuzumab administered every three weeks in combination with paclitaxel
-
Leyland-Jones B et al. (2003) Pharmacokinetics, safety, and efficacy of trastuzumab administered every three weeks in combination with paclitaxel. J Clin Oncol 21: 3965-3971
-
(2003)
J Clin Oncol
, vol.21
, pp. 3965-3971
-
-
Leyland-Jones, B.1
-
21
-
-
19344364880
-
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
-
Early Breast Cancer Trialists' Collaborative Group
-
Early Breast Cancer Trialists' Collaborative Group: (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet 265: 1687-1717
-
(2005)
Lancet
, vol.265
, pp. 1687-1717
-
-
-
22
-
-
34547852275
-
Progress and promise: Highlights of the international expert consensus on the primary therapy of early breast cancer 2007
-
Goldhirsh A et al. (2007) Progress and promise: Highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Ann Oncol 18: 1133-1144
-
(2007)
Ann Oncol
, vol.18
, pp. 1133-1144
-
-
Goldhirsh, A.1
-
23
-
-
0346258221
-
Tailoring adjuvant treatments for the individual breast cancer patient
-
Gelber RD et al. (2003) Tailoring adjuvant treatments for the individual breast cancer patient. The Breast 12: 558-568
-
(2003)
The Breast
, vol.12
, pp. 558-568
-
-
Gelber, R.D.1
-
24
-
-
34548433016
-
Clinical strategies for rationale combinations of aromatase inhibitors with novel therapies for breast cancer
-
Johnston SR et al. (2007) Clinical strategies for rationale combinations of aromatase inhibitors with novel therapies for breast cancer. J Steroid Biochem Mol Biol 106: 180-186
-
(2007)
J Steroid Biochem Mol Biol
, vol.106
, pp. 180-186
-
-
Johnston, S.R.1
-
25
-
-
0037420192
-
Role of estrogen receptor coactivator AIB1 (SRC3) and HER-2/neu in tamoxifen resistance in breast cancer
-
Osborne CK et al. (2003) Role of estrogen receptor coactivator AIB1 (SRC3) and HER-2/neu in tamoxifen resistance in breast cancer. J Natl Cancer Inst 95: 353-361
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 353-361
-
-
Osborne, C.K.1
-
26
-
-
34249011160
-
Trastuzumab prolongs progression-free survival in hormone-dependent and HER-2 positive metastatic breast cancer
-
Presented at the, December 14-17
-
Mackey JR et al. (2006) Trastuzumab prolongs progression-free survival in hormone-dependent and HER-2 positive metastatic breast cancer. Presented at the San Antonio Breast Cancer Symposium. 2006 December 14-17 [http://www.abstracts2view.com/sabcs06/ view.php?nu=SABCS06L_665]
-
(2006)
San Antonio Breast Cancer Symposium
-
-
Mackey, J.R.1
-
27
-
-
16644362006
-
Correlation between topoisomerase II-alpha gene amplification and protein expression in HER-2 amplified breast cancer
-
Durbecq V et al. (2004) Correlation between topoisomerase II-alpha gene amplification and protein expression in HER-2 amplified breast cancer. Int J Oncol 25: 1473-1479
-
(2004)
Int J Oncol
, vol.25
, pp. 1473-1479
-
-
Durbecq, V.1
-
28
-
-
7444252789
-
Topoisomerase-II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel
-
Durbecq V et al. (2004) Topoisomerase-II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel. Mol Cancer Ther 3: 1207-1214
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1207-1214
-
-
Durbecq, V.1
-
29
-
-
3843120055
-
Correlation between complete response to anthracycline-based chemotherapy and topoisomerase-II gene amplification and protein overexpression in locally advanced/metastatic breast cancer
-
Cardoso F et al. (2004) Correlation between complete response to anthracycline-based chemotherapy and topoisomerase-II gene amplification and protein overexpression in locally advanced/metastatic breast cancer. Int J Oncol 24: 201-209
-
(2004)
Int J Oncol
, vol.24
, pp. 201-209
-
-
Cardoso, F.1
-
30
-
-
33746875523
-
Topoisomerase II-alpha gene deletion is not as frequent as its amplification in breast cancer
-
Park K et al. (2006) Topoisomerase II-alpha gene deletion is not as frequent as its amplification in breast cancer. Breast Cancer Res Treat 98: 337-342
-
(2006)
Breast Cancer Res Treat
, vol.98
, pp. 337-342
-
-
Park, K.1
-
31
-
-
33744969590
-
Topoisomerase II-alpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401
-
Tanner M et al. (2006) Topoisomerase II-alpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401. J Clin Oncol 24 2409-2411
-
(2006)
J Clin Oncol
, vol.24
, pp. 2409-2411
-
-
Tanner, M.1
-
32
-
-
32944475493
-
Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophoshamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group
-
Knoop AS et al. (2005) Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophoshamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J Clin Oncol 23: 7483-7490
-
(2005)
J Clin Oncol
, vol.23
, pp. 7483-7490
-
-
Knoop, A.S.1
-
33
-
-
0036554731
-
Amplification and overexpression of topoisomerase II-alpha predict response to anthracycline-based therapy in locally advanced breast cancer
-
Coon JS et al. (2002) Amplification and overexpression of topoisomerase II-alpha predict response to anthracycline-based therapy in locally advanced breast cancer. Clin Cancer Res 8: 1061-1067
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1061-1067
-
-
Coon, J.S.1
-
34
-
-
0036091354
-
HER-2 amplification and topoisomerase II-alpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil
-
Di Leo A et al. (2002) HER-2 amplification and topoisomerase II-alpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin Cancer Res 8: 1107-1116
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1107-1116
-
-
Di Leo, A.1
-
35
-
-
0037333625
-
Topoisomerase II-alpha (topoII) and HER-2 amplification in breast cancers and response to preoperative doxorubicin chemotherapy
-
Park K et al. (2003) Topoisomerase II-alpha (topoII) and HER-2 amplification in breast cancers and response to preoperative doxorubicin chemotherapy. Eur J Cancer 39: 631-634
-
(2003)
Eur J Cancer
, vol.39
, pp. 631-634
-
-
Park, K.1
-
36
-
-
0037738887
-
Her-2/neu and topoisomerase II alpha in breast cancer
-
Jarvinen TA and Liu ET (2003) Her-2/neu and topoisomerase II alpha in breast cancer. Breast Cancer Res 78: 299-311
-
(2003)
Breast Cancer Res
, vol.78
, pp. 299-311
-
-
Jarvinen, T.A.1
Liu, E.T.2
-
37
-
-
0029781038
-
Selection of a subpopulation with fever DNA topoisomerase II α gene copies in a doxorubicin-resistant cell line panel
-
Withoff S et al. (1996) Selection of a subpopulation with fever DNA topoisomerase II α gene copies in a doxorubicin-resistant cell line panel. Br J Cancer 74: 502-507
-
(1996)
Br J Cancer
, vol.74
, pp. 502-507
-
-
Withoff, S.1
-
38
-
-
0043145754
-
Characterisation of topoisomerase II α gene amplification and deletion in breast cancer
-
Jarvinen TA et al. (1999) Characterisation of topoisomerase II α gene amplification and deletion in breast cancer. Genes Chromosomes Cancer 26: 142-150
-
(1999)
Genes Chromosomes Cancer
, vol.26
, pp. 142-150
-
-
Jarvinen, T.A.1
-
39
-
-
28044453732
-
Adjuvant trastuzumab for breast cancer: The other side of the coin
-
Gopalakrishnan S and Linnane J (2005) Adjuvant trastuzumab for breast cancer: The other side of the coin. BMJ 331: 1202-1203
-
(2005)
BMJ
, vol.331
, pp. 1202-1203
-
-
Gopalakrishnan, S.1
Linnane, J.2
-
40
-
-
34247551377
-
Economic evaluation of the prevention and treatment of breast cancer-present status and open issues
-
Imai H et al. (2007) Economic evaluation of the prevention and treatment of breast cancer-present status and open issues. Breast Cancer 14: 81-87
-
(2007)
Breast Cancer
, vol.14
, pp. 81-87
-
-
Imai, H.1
-
41
-
-
33947605979
-
Cost effectiveness of adjuvant trastuzumab in human epidermal growth factor receptor 2-positive breast cancer
-
Liberato NL et al. (2007) Cost effectiveness of adjuvant trastuzumab in human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 25: 625-633
-
(2007)
J Clin Oncol
, vol.25
, pp. 625-633
-
-
Liberato, N.L.1
-
42
-
-
43749104288
-
The model-based cost-effectiveness analysis of 1-year adjuvant trastuzumab treatment: Based on 2-year follow-up HERA trial data
-
Shiroiwa T et al. (2007) The model-based cost-effectiveness analysis of 1-year adjuvant trastuzumab treatment: Based on 2-year follow-up HERA trial data. Breast Cancer Res Treat 109: 559-566
-
(2007)
Breast Cancer Res Treat
, vol.109
, pp. 559-566
-
-
Shiroiwa, T.1
-
43
-
-
33644670516
-
An economic evaluation of Herceptin in adjuvant setting: The Breast Cancer International Research Group 006 trial
-
Neyt M et al. (2006) An economic evaluation of Herceptin in adjuvant setting: The Breast Cancer International Research Group 006 trial. Ann Oncol 17: 381-390
-
(2006)
Ann Oncol
, vol.17
, pp. 381-390
-
-
Neyt, M.1
-
44
-
-
34248376048
-
Cost effectiveness of trastuzumab in the adjuvant treatment of early breast cancer: A lifetime model
-
Millar JA and Millward MJ (2007) Cost effectiveness of trastuzumab in the adjuvant treatment of early breast cancer: A lifetime model. Pharmacoeconomics 25: 429-442
-
(2007)
Pharmacoeconomics
, vol.25
, pp. 429-442
-
-
Millar, J.A.1
Millward, M.J.2
-
45
-
-
12544250996
-
Decreased accessibility and lack of activation or ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line
-
Nagy P et al. (2005) Decreased accessibility and lack of activation or ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res 65: 473-482
-
(2005)
Cancer Res
, vol.65
, pp. 473-482
-
-
Nagy, P.1
-
46
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata Y et al. (2004) PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6: 117-127
-
(2004)
Cancer Cell
, vol.6
, pp. 117-127
-
-
Nagata, Y.1
-
47
-
-
2542526069
-
p27(kip1) downregulation is associated with trastuzumab resistance in breast cancer cells
-
Nahta R et al. (2004) p27(kip1) downregulation is associated with trastuzumab resistance in breast cancer cells. Cancer Res 64 3981-3986
-
(2004)
Cancer Res
, vol.64
, pp. 3981-3986
-
-
Nahta, R.1
-
48
-
-
0035915421
-
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
-
Lu YH et al. (2001) Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Nat Cancer Inst 93: 1852-1857
-
(2001)
J Nat Cancer Inst
, vol.93
, pp. 1852-1857
-
-
Lu, Y.H.1
-
49
-
-
28244432561
-
Insulin-like growth factor-I receptor/ human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
Nahta R et al. (2005) Insulin-like growth factor-I receptor/ human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 65 11118-11128
-
(2005)
Cancer Res
, vol.65
, pp. 11118-11128
-
-
Nahta, R.1
|