Separate recording of A-delta and C fiber-mediated nociceptive flexor reflex responses of mouse hindlimb using electromyography and the characteristics of wind-up appearing in the responses

Journal of Pharmacological Sciences

Volumn 108, Issue 2, 2008, Pages 172-178

  Kimura, Satoko ^a   Kontani, Hitoshi ^a  

^a HOKURIKU UNIVERSITY   (Japan)

Author keywords

A delta fiber; C fiber; Electromyogram; Nociceptive flexor reflex; Wind up

Indexed keywords

CAPSAICIN; TETRODOTOXIN;

AFFERENT NERVE GROUP 1; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; ELECTROMYOGRAPHY; ELECTROSTIMULATION; FLEXOR REFLEX; HINDLIMB; LATENT PERIOD; LEG MUSCLE; MALE; MOUSE; NERVE FIBER A DELTA; NERVE FIBER C; NOCICEPTION; NONHUMAN; SCIATIC NERVE; WITHDRAWAL REFLEX;

EID: 55549108091     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08104FP     Document Type: Article

References (22)

1. Cocito D, Paolasso I, Pazzaglia C, Tavella A, Poglio F, Ciaramitaro P, et al. Pain affects the quality of life of neuropathic patients. Neurol Sci. 2006;27:155-160.
2. Le Bars D, Guilbaud G, Jurna I, Besson JM. Differential effects of morphine on responses of dorsal horn lamina V type cells elicited by A and C fibre stimulation in the spinal cat. Brain Res. 1976;115:518-524.
3. Villanueva L, Chitour D, Le Bars D. Effects of tizanidine (DS 103-282) on dorsal horn convergent neurones in the rat. Pain. 1988;35:187-197.
4. Falinower S, Willer JC, Junien JL, Le Bars D. A C-fiber reflex modulated by heterotopic noxious somatic stimuli in the rat. J Neurophysiol. 1994;72:194-213.
5. Schomburg ED, Steffens H, Mense S. Contribution of TTX-resistant C-fibres and Aδ-fibres to nociceptive flexor-reflex and non-flexor-reflex pathways in cats. Neurosci Res. 2000;37: 277-287.
6. Zhu B, Xu WD, Rong PJ, Ben H, Gao XY. A C-fiber reflex inhibition induced by electroacupuncture with different intensities applied at homotopic and heterotopic acupoints in rats selectively destructive effects on myelinated and unmyelinated afferent fibers. Brain Res. 2004;1011:228-237.
7. B receptors on central terminals of C-afferents mediate intersegmental AAδ-afferent evoked hypoalgesia. Eur J Pain. 2005;9:233-242.
8. Matsumoto M, Inoue M, Hald A, Xie W, Ueda H. Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin. J Pharmacol Exp Ther. 2006;318:735-740.
9. Kimura S, Honda M, Tanabe M, Ono H. Noxious stimuli evoke a biphasic flexor reflex composed of Aδ-fiber-mediated short-latency and C-fiber-mediated long-latency withdrawal movements in mice. J Pharmacol Sci. 2004;95:94-100.
10. Kerr BJ, Gupta Y, Pope R, Thompson SW, Wynick D, McMahon SB. Endogenous galanin potentiates spinal nociceptive processing following inflammation. Pain. 2001;93:267-277.
11. Grass S, Crawley JN, Xu XJ, Wiesenfeld-Hallin Z. Reduced spinal cord sensitization to C-fibre stimulation in mice overexpressing galanin. Eur J Neurosci. 2003;17:1829-1832.
12. Mendell LM, Wall PD. Responses of single dorsal cord cells to peripheral cutaneous unmyelinated fibres. Nature. 1965;206:97-99.
13. Herrero JF, Laird JM, López-García JA. Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol. 2000;61:169-203.
14. Kimura S, Tanabe M, Honda M, Ono H. Enhanced wind-up of the C-fiber-mediated nociceptive flexor reflex movement following painful diabetic neuropathy in mice. J Pharmacol Sci. 2005;97:195-202.
15. Herrero JF, Cervero F. Changes in nociceptive reflex facilitation during carrageenan-induced arthritis. Brain Res. 1996;717:62-68.
16. Hedo G, Laird JM, Lopez-Garcia JA. Time-course of spinal sensitization following carrageenan-induced inflammation in the young rat: a comparative electrophysiological and behavioural study in vitro and in vivo. Neuroscience. 1999;92:309-318.
17. Clarke RW, Eves S, Harris J, Peachey JE, Stuart E. Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems. Neuroscience. 2002;112:555-571.
18. Schouenborg J, Sjölund BH. Activity evoked by A- and C- afferent fibers in rat dorsal horn neurons and its relation to a flexion reflex. J Neurophysiol. 1983;50:1108-1121.
19. Clarke RW, Brown-Reid K, Kasher P, Harris J. Tetrodotoxin block of A-fibre conduction and its effect on reflex responses evoked by electrical stimulation of the sural nerve in the decerebrated rabbit. Exp Physiol. 2003;88:13-18.
20. Steffens H, Hoheisel U, Eek B, Mense S. Tetrodotoxin-resistant conductivity and spinal effects of cutaneous C-fibre afferents in the rat. Neurosci Res. 2001;39:413-419.
21. Baranowski R, Lynn B, Pini A. The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species. Br J Pharmacol. 1986;89:267-276.
22. Pinto V, Derkach VA, Safronov BV. Role of TTX-sensitive and TTX-resistant sodium channels in Aδ- and C-fiber conduction and synaptic transmission. J Neurophysiol. 2008;99:617-628.