Histologic features and prognosis in pediatric medulloblastoma

Pediatric and Developmental Pathology

Volumn 11, Issue 5, 2008, Pages 337-343

  Verma, Shalini ^a   Tavaré, C Jane ^b   Gilles, Floyd H ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Anaplastic medulloblastoma; Desmoplastic nodular medulloblastoma; Large cell medulloblastoma; Medulloblastoma; Medulloblastoma with extensive nodularity

Indexed keywords

ANAPLASTIC LARGE CELL MEDULLOBLASTOMA; ARTICLE; CELL DENSITY; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; NECROSIS; NUCLEOLUS; PRIORITY JOURNAL; PROGNOSIS; RELIABILITY; SURVIVAL; WORLD HEALTH ORGANIZATION;

CEREBELLAR NEOPLASMS; CHILD; HUMANS; MEDULLOBLASTOMA; PROGNOSIS; SURVIVAL ANALYSIS;

EID: 55449136449     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/07-09-0353.1     Document Type: Article

References (36)

1. Bailey P, Cushing H. Medulloblastoma cerebelli; a common type of midcerebellar glioma of childhood. Arch Neurol Psych 1925;14:192-224.
2. Rubinstein LJ, Northfield DW. The medulloblastoma and the so-called "arachnoidal cerebellar sarcoma." Brain 1964;87:379-412.
3. Kleihues P, Cavenee W. Pathology and Genetics of Tumors of the Nervous System. Lyon, France: IARC Press, 2000.
4. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification of Tumours of the Central Nervous System. Lyon, France: International Agency for Research on Cancer, 2007.
5. Kernohan JW, Uihlein A. Sarcomas of the brain. Springfield: C.C. Thomas, 1962.
6. Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol (Berl) 2007;114:97-109.
7. Giangaspero F, Eberhart CC, Haapasalo H, Pietsch T, Wiestler OD, Ellison DW. Medulloblastoma, 4th ed. Lyon, France: International Agency for Research on Cancer, 2007.
8. Chatty EM, Earle KM. Medulloblastoma. A report of 201 cases with emphasis on the relationship of histologic variants to survival. Cancer 1971;28:977-983.
9. Giangaspero F, Chieco P, Ceccarelli C, et al. "Desmoplastic" versus "classic" medulloblastoma: comparison of DNA content, histopathology and differentiation. Virchows Arch A Pathol Anat Histopathol 1991;418:207-214.
10. Sure U, Berghorn W, Bertalanffy H. Staging, scoring and grading of medulloblastoma: a postoperative prognosis predicting system based on the case of a single institute. Acta Neurochir (Wien) 1995;132:59-65.
11. Weil MD, Lamborn K, Edwards MS, Wara WM. Influence of a child's sex on medulloblastoma outcome. JAMA 1998;279:1474-1476.
12. McManamy CS, Pears J, Weston CL, et al. Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior. Brain Pathol 2007;17:151-164.
13. Muller W, Afra D, Schroder R, Slowik F, Wilcke O, Klug N. Medulloblastoma: survey of factors possibly influencing the prognosis. Acta Neurochir (Wien) 1982;64:215-224.
14. Eberhart CG, Kepner JL, Goldthwaite PT, et al. Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 2002;94:552-560.
15. Urberuaga A, Navajas A, Burgos J, Pijoan JI. A review of clinical and histological features of Spanish paediatric medulloblastomas during the last 21 years. Childs Nerv Syst 2006;22:466-474.
16. Giangaspero F, Rigobello L, Badiali M, et al. Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. Am J Surg Pathol 1992;16:687-693.
17. Brown HG, Kepner JL, Perlman EJ, et al. "Large cell/anaplastic" medulloblastomas: a Pediatric Oncology Group Study. J Neuropathol Exp Neurol 2000;59:857-865.
18. Eberhart CG, Burger PC. Anaplasia and grading in medulloblastomas. Brain Pathol 2003;13:376-385.
19. McManamy CS, Lamont JM, Taylor RE, et al. Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas. J Neuropathol Exp Neurol 2003;62:627-632.
20. Giangaspero F, Wellek S, Masuoka J, Gessi M, Kleihues P, Ohgaki H. Stratification of medulloblastoma on the basis of histopathological grading. Acta Neuropathol (Berl) 2006;112:5-12.
21. Min HS, Lee YJ, Park K, Cho BK, Park SH. Medulloblastoma: histopathologic and molecular markers of anaplasia and biologic behavior. Acta Neuropathol (Berl) 2006;112:13-20.
22. Pizem J, Cor A, Zadravec Zaletel L, Popovic M. Prognostic significance of apoptosis in medulloblastoma. Neurosci Lett 2005;381:69-73.
23. Dagostino C, Clara E, Chio A, Giordana MT. Morphophenotype of medulloblastoma in children and adults. The size of nuclei. Clin Neuropathol 2006;25:227-231.
24. Childhood Brain Tumor Consortium. A study of childhood brain tumors based on surgical biopsies from ten North American institutions: sample description. J Neuro-Oncol 1988;6:9-23.
25. Young JL Jr, Miller RW. Incidence of malignant tumors in US children. J Pediatr 1975;86:254-258.
26. Leviton A. Principles of epidemiology. In: Cohen ME, Duffner PK, eds. Brain Tumors in Children: Principles of Diagnosis and Treatment. New York: Raven Press, Ltd., 1994;27-49.
27. Zülch KJ. Histological Typing of Tumors of the Central Nervous System. Geneva: World Health Organization, 1979.
28. Cohen J. A coefficient of agreement for nominal scales. Educ Psychol Meas 1960;20:37-46.
29. Svanholm H, Starklint H, Gundersen HJG, Fabricius J, Barlebo H, Olsen S. Reproducibility of histomorphologic diagnoses with special reference to the kappa statistic. APMIS 1989;97:689-698.
30. Gilles FH, Sobel EL, Leviton A, Tavaré CJ, Hedley-Whyte ET. Histologic feature reliability in childhood neural tumors. J Neuropathol Exp Neurol 1994;53:559-571.
31. Albright AL, Wisoff JH, Zeltzer PM, Boyett JM, Rorke LB, Stanley P. Effects of medulloblastoma resections on outcome in children: a report from the Children's Cancer Group. Neurosurgery 1996;38(2):265-271.
32. Zeltzer PM, Boyett JM, Finlay JL, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol 1999;17:832-845.
33. Giangaspero F, Perilongo G, Fondelli MP, et al. Medulloblastoma with extensive nodularity: a variant with favorable prognosis. J Neurosurg 1999;91:971-977.
34. Lamont JM, McManamy CS, Pearson AD, Clifford SC, Ellison DW. Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin Cancer Res 2004;10:5482-5493.
35. Childhood Brain Tumor Consortium. Intraobserver reproducibility in assigning brain tumors to classes in the World Health Organization diagnostic scheme. J Neuro-Oncol 1989;7:211-224.
36. Cochran WG. Errors of measurement in statistics. Technometrics 1968;10:637-666.